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SDG 3: Antimicrobial resistance

Abstract

Background

is the leading cause of urinary tract infections (UTI) and bloodstream infections (BSI), and the emergence of antimicrobial resistance (AMR) in causes concern.

Aim

To investigate changes in the proportion of extended-spectrum β-lactamase (ESBL) producing isolates among isolated from urine and blood in Finland during 2008–2019.

Methods

Susceptibility testing of 1,568,488 urine (90% female, 10% male) and 47,927 blood isolates (61% female, 39% male) from all Finnish clinical microbiology laboratories during 2008–2019 was performed according to guidelines from the Clinical and Laboratory Standard Institute during 2008–2010 and the European Committee on Antimicrobial Susceptibility Testing during 2011–2019. A binomial regression model with log link compared observed trends over time and by age group and sex.

Results

The annual proportion of ESBL-producing  isolates among from blood cultures increased from 2.4% (23/966) to 8.6% (190/2,197) among males (average annual increase 7.7%; 95% CI: 4.4–11.0%, p < 0.01) and from 1.6% (28/1,806) to 6.4% (207/3,218) among females (9.3%; 95% CI: 4.8–14.0%, p < 0.01). In urine cultures, the proportion of ESBL-producing isolates increased from 2.2% (239/10,806) to 7.2% (1,098/15,297) among males (8.8%; 95% CI: 6.5–11.3%, p < 0.01) and from 1.0% (1,045/108,390) to 3.1% (3,717/120,671) among females (8.6%; 95% CI: 6.3–11.0%, p < 0.01). A significant increase was observed within most age groups.

Conclusions

Considering the ageing population and their risk of BSI and UTI, the increase in the annual proportions of ESBL-producing  is concerning, and these increasing trends should be carefully monitored.

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2023-10-26
2024-04-28
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Increasing proportions of extended-spectrum β-lactamase-producing isolates among Escherichia coli from urine and bloodstream infections: results from a nationwide surveillance network, Finland, 2008 to 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Heikki+Ilmavirta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ilmavirta Heikki</a>, <a href="/search?value1=Jukka+Ollgren&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ollgren Jukka</a>, <a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>, <a href="/search?value1=Tuure+Kinnunen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kinnunen Tuure</a>, <a href="/search?value1=Antti+J+Hakanen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hakanen Antti J</a>, <a href="/search?value1=Jari+Jalava&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jalava Jari</a>, <a href="/search?value1=Outi+Lyytik%C3%A4inen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lyytikäinen Outi</a></span>. Increasing proportions of extended-spectrum β-lactamase-producing isolates among Escherichia coli from urine and bloodstream infections: results from a nationwide surveillance network, Finland, 2008 to 2019. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(43):pii=2200934. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.43.2200934" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.43.2200934</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 08 Dec 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 May 2023 </span> </p>
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