Rapid communication Open Access
Like 0


From April 2023 to May 2024, an unusual epidemic of parvovirus B19 (B19V) infections occurred in France. The number of B19V IgM-positive serologies was four times higher than in the previous epidemic in 2019. Clinical data from emergency networks corroborated this observation. Morbidity and mortality consequences were observed in children through all data sources. In adults, the increase was only observed in laboratory-confirmed data. Physicians and decisionmakers should be informed in order to better prevent, diagnose and manage at-risk patients.


Article metrics loading...

Loading full text...

Full text loading...



  1. Jacquot R, Gerfaud-Valentin M, Mekki Y, Billaud G, Jamilloux Y, Sève P. Infection de l’adulte à Parvovirus. Rev Med Interne. 2022;43(12):713-26.  https://doi.org/10.1016/j.revmed.2022.08.005  PMID: 36088203 
  2. Fourgeaud J, Allali S, Toubiana J, Pinhas Y, Frange P, Leruez-Ville M, et al. Post-COVID-19 pandemic outbreak of severe Parvovirus B19 primary infections in Paris, France: 10-year interrupted time-series analysis (2012-2023). J Clin Virol. 2023;167:105576.  https://doi.org/10.1016/j.jcv.2023.105576  PMID: 37633184 
  3. Akiner MM, Demirci B, Babuadze G, Robert V, Schaffner F. Spread of the invasive mosquitoes Aedes aegypti and Aedes albopictus in the Black Sea region increases risk of chikungunya, dengue, and Zika outbreaks in Europe. PLoS Negl Trop Dis. 2016;10(4):e0004664.  https://doi.org/10.1371/journal.pntd.0004664  PMID: 27115737 
  4. Franke F, Septfons A, Leparc-Goffart I, Silvana G, Guinard A, Burdet S. Surveillance du chikungunya, de la dengue et des infections à virus Zika en France métropolitaine, 2016. [Surveillance of chikungunya, dengue and Zika virus infections in metropolitan France, 2016]. Bull Epidemiol Hebd.2017;12:222-31. French.
  5. Che D, Desenclos J. L’alerte dans la surveillance actuelle des maladies infectieuses. Med Mal Infect. 2002;32(12):704-16.  https://doi.org/10.1016/S0399-077X(02)00457-2 
  6. Caserio-Schönemann C, Bousquet V, Fouillet A, Henry V. Le système de surveillance syndromique SurSaUD (R). [The syndromic surveillance system SurSaUD]. Bull Epidemiol Hebd (Paris). 2014;3:38-44. French.
  7. Thiam MM, Pontais I, Forgeot C, Pedrono G, Paget LM, Fouillet A, et al. Syndromic surveillance: A key component of population health monitoring during the first wave of the COVID-19 outbreak in France, February-June 2020. PLoS One. 2022;17(2):e0260150.  https://doi.org/10.1371/journal.pone.0260150  PMID: 35143501 
  8. Fouillet A, Pigeon D, Carton I, Robert A, Pontais I, Caserio-Schönemann I, et al. Evolution de la certification électronique des décès en France de 2011 à 2018. [Evolution of electronic death certification on France from 2011 to 2018]. Bull Epidemiol Hebd (Paris). 2019; (29-30):585-93. French.
  9. Guillet M, Bas A, Lacoste M, Ricard C, Visse C, Barlet V, et al. New atypical epidemiological profile of parvovirus B19 revealed by molecular screening of blood donations, France, winter 2023/24. Euro Surveill. 2024;29(21):2400253.  https://doi.org/10.2807/1560-7917.ES.2024.29.21.2400253  PMID: 38785091 
  10. Mor O, Wax M, Arami SS, Yitzhaki M, Kriger O, Erster O, et al. Parvovirus B19 outbreak in Israel: retrospective molecular analysis from 2010 to 2023. Viruses. 2024;16(3):480.  https://doi.org/10.3390/v16030480  PMID: 38543845 
  11. European Centre for Disease Prevention and Control (ECDC). Communicable disease threats report. Week 16 14-20 April 2024. Stockholm: ECDC; 2024. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/communicable-disease-threats-report-week-16-2024_final.pdf
  12. Nordholm AC, Trier Møller F, Fischer Ravn S, Flink Sørensen L, Moltke-Prehn A, Elskær Mollerup J, et al. Epidemic of parvovirus B19 and disease severity in pregnant people, Denmark, January to March 2024. Euro Surveill. 2024;29(24):2400299.  https://doi.org/10.2807/1560-7917.ES.2024.29.24.2400299  PMID: 38873795 
  13. Messacar K, Baker RE, Park SW, Nguyen-Tran H, Cataldi JR, Grenfell B. Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption. Lancet. 2022;400(10364):1663-5.  https://doi.org/10.1016/S0140-6736(22)01277-6  PMID: 35843260 
  14. Cohen R, Ashman M, Taha MK, Varon E, Angoulvant F, Levy C, et al. Pediatric Infectious Disease Group (GPIP) position paper on the immune debt of the COVID-19 pandemic in childhood, how can we fill the immunity gap? Infect Dis Now. 2021;51(5):418-23.  https://doi.org/10.1016/j.idnow.2021.05.004  PMID: 33991720 
  15. Iro MA, Goldacre MJ, Morris EJ, Goldacre R. Hospital admissions for group A streptococcal infections in England: current rates and historical perspective. Lancet Infect Dis. 2023;23(9):e326-7.  https://doi.org/10.1016/S1473-3099(23)00428-0  PMID: 37480931 
  16. Meyer Sauteur PM, Beeton ML, Pereyre S, Bébéar C, Gardette M, Hénin N, et al. Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions. Lancet Microbe. 2024;5(2):e100-1.  https://doi.org/10.1016/S2666-5247(23)00344-0  PMID: 38008103 
  17. Molenaar-de Backer MW, Hogema BM, Koppelman MH, van de Laar TJ, Slot E, Zaaijer HL. Lower incidence of parvovirus-B19 infections in Dutch blood donors during SARS-CoV-2 pandemic. Microbiol Spectr. 2021;9(2):e0025321.  https://doi.org/10.1128/Spectrum.00253-21  PMID: 34523999 
  18. Santé publique France. Épidémie d’infections à Parvovirus B19. [Epidemic of parvovirus B-19 infections]. Paris: Santé publique France; 2024. French. Available from: https://www.santepubliquefrance.fr/content/download/620047/4261122?version=2#:~:text=Une%20%C3%A9pid%C3%A9mie%20d'infections%20%C3%A0,atteint%20au%20mois%20de%20mars

Data & Media loading...

Supplementary data

Submit comment
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error