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Under International Health Regulations from 2005, a human infection caused by a novel influenza A virus variant is considered an event that has potential for high public health impact and is immediately notifiable to the World Health Organisation. We here describe the clinical, epidemiological and virological features of a confirmed human case of swine influenza A(H1N2)v in England detected through community respiratory virus surveillance. Swabbing and contact tracing helped refine public health risk assessment, following this unusual and unexpected finding.


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  1. Leston M, Elson WH, Watson C, Lakhani A, Aspden C, Bankhead CR, et al. Representativeness, vaccination uptake, and COVID-19 clinical outcomes 2020-2021 in the UK Oxford-Royal College of General Practitioners Research and Surveillance Network: cohort profile summary. JMIR Public Health Surveill. 2022;8(12):e39141.  https://doi.org/10.2196/39141  PMID: 36534462 
  2. Gu X, Watson C, Agrawal U, Whitaker H, Elson WH, Anand S, et al. Post-pandemic development of sentinel surveillance of respiratory disease, in the context of the WHO mosaic framework: protocol for the English primary care network 2023-2024. JMIR Preprints. 30/08/2023:52047:  https://doi.org/10.2196/preprints.52047  https://doi.org/10.2196/preprints.52047 
  3. Zhou B, Donnelly ME, Scholes DT, St George K, Hatta M, Kawaoka Y, et al. Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol. 2009;83(19):10309-13.  https://doi.org/10.1128/JVI.01109-09  PMID: 19605485 
  4. Anderson TK, Macken CA, Lewis NS, Scheuermann RH, Van Reeth K, Brown IH, et al. A phylogeny-based global nomenclature system and automated annotation tool for H1 hemagglutinin genes from swine influenza A viruses. MSphere. 2016;1(6):e00275-16.  https://doi.org/10.1128/mSphere.00275-16  PMID: 27981236 
  5. World Health Organization (WHO). Genetic and antigenic characteristics of zoonotic influenza A viruses and development of candidate vaccine viruses for pandemic preparedness. Geneva: WHO; 2023. Available from: https://cdn.who.int/media/docs/default-source/influenza/who-influenza-recommendations/vcm-northern-hemisphere-recommendation-2023-2024/20230224_zoonotic_recommendations.pdf?sfvrsn=38c739fa_4
  6. UK Health Security Agency (UKHSA). Influenza A(H1N2)V: Rapid technical assessment. London: GOV.UK; 2023. Available from: https://www.gov.uk/government/publications/influenza-ah1n2v-technical-briefings/influenza-ah1n2v-rapid-technical-assessment
  7. UK Health Security Agency (UKHSA). National Influenza and COVID-19 surveillance report – Week 50 report (up to week 49 data). London: GOV.UK; 2023. Available from: https://assets.publishing.service.gov.uk/media/657b1451254aaa0010050d94/Weekly-flu-and-COVID-19-surveillance-report-week50-correction.pdf
  8. Brown IH, Harris PA, McCauley JW, Alexander DJ. Multiple genetic reassortment of avian and human influenza A viruses in European pigs, resulting in the emergence of an H1N2 virus of novel genotype. J Gen Virol. 1998;79(Pt 12):2947-55.  https://doi.org/10.1099/0022-1317-79-12-2947  PMID: 9880008 
  9. Centers for Disease Control and Prevention (CDC). Novel influenza A virus infections. Atlanta: CDC. [Accessed: 17 Jan 2024]. Available from: https://gis.cdc.gov/grasp/fluview/Novel_Influenza.html
  10. World Health Organisation (WHO). Influenza A (H1N1) variant virus - the Netherlands. Geneva: WHO; 2023. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON486
  11. European Centre for Disease Control (ECDC). Testing and detection of zoonotic influenza virus infections in humans in the EU/EEA, and occupational safety and health measures for those exposed at work. Stockholm: ECDC; 2022. Available from: https://www.ecdc.europa.eu/en/publications-data/zoonotic-influenza-virus-infections-humans-testing-and-detection

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