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SDG 3: STI

Abstract

Background

Antimicrobial resistance (AMR) of (MG) is a growing concern worldwide and surveillance is needed. In Belgium, samples are sent to the National Reference Centre of Sexually Transmitted Infections (NRC-STI) on a voluntary basis and representative or robust national AMR data are lacking.

Aim

We aimed to estimate the occurrence of resistant MG in Belgium.

Methods

Between July and November 2022, frozen remnants of MG-positive samples from 21 Belgian laboratories were analysed at the NRC-STI. Macrolide and fluoroquinolone resistance-associated mutations (RAMs) were assessed using Sanger sequencing of the 23SrRNA and gene. Differences in resistance patterns were correlated with surveillance methodology, socio-demographic and behavioural variables via Fisher’s exact test and logistic regression analysis.

Results

Of the 244 MG-positive samples received, 232 could be sequenced for macrolide and fluoroquinolone RAMs. Over half of the sequenced samples (55.2%) were resistant to macrolides. All sequenced samples from men who have sex with men (MSM) (24/24) were macrolide-resistant. Fluoroquinolone RAMs were found in 25.9% of the samples and occurrence did not differ between socio-demographic and sexual behaviour characteristics.

Conclusion

Although limited in sample size, our data suggest no additional benefit of testing MG retrieved from MSM for macrolide resistance in Belgium, when making treatment decisions. The lower occurrence of macrolide resistance in other population groups, combined with emergence of fluoroquinolone RAMs support macrolide-resistance testing in these groups. Continued surveillance of resistance in MG in different population groups will be crucial to confirm our findings and to guide national testing and treatment strategies.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2024-02-15
2024-04-29
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.7.2300318
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Estimation of antimicrobial resistance of Mycoplasma genitalium, Belgium, 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Irith+De+Baetselier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Baetselier Irith</a>, <a href="/search?value1=Hilde+Smet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Smet Hilde</a>, <a href="/search?value1=Kaat+Kehoe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kehoe Kaat</a>, <a href="/search?value1=Imelda+Loosen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Loosen Imelda</a>, <a href="/search?value1=Marijke+Reynders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynders Marijke</a>, <a href="/search?value1=Iqbal+Mansoor&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mansoor Iqbal</a>, <a href="/search?value1=Lorenzo+Filippin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Filippin Lorenzo</a>, <a href="/search?value1=Mathieu+Cauchie&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cauchie Mathieu</a>, <a href="/search?value1=Ellen+Van+Even&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Even Ellen</a>, <a href="/search?value1=Nadia+Makki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Makki Nadia</a>, <a href="/search?value1=Gilberte+Schiettekatte&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schiettekatte Gilberte</a>, <a href="/search?value1=Wouter+Vandewal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vandewal Wouter</a>, <a href="/search?value1=Bart+Glibert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Glibert Bart</a>, <a href="/search?value1=Veerle+Matheeussen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matheeussen Veerle</a>, <a href="/search?value1=Yolien+Van+der+Beken&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van der Beken Yolien</a>, <a href="/search?value1=Reinoud+Cartuyvels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cartuyvels Reinoud</a>, <a href="/search?value1=Sophia+Steyaert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Steyaert Sophia</a>, <a href="/search?value1=Ann+Lemmens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lemmens Ann</a>, <a href="/search?value1=Maria-Grazia+Garrino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Garrino Maria-Grazia</a>, <a href="/search?value1=Henry+Paridaens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paridaens Henry</a>, <a href="/search?value1=Elena+Lazarova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lazarova Elena</a>, <a href="/search?value1=B%C3%A9n%C3%A9dicte+Lissoir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lissoir Bénédicte</a>, <a href="/search?value1=Marine+Deffontaine&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deffontaine Marine</a>, <a href="/search?value1=Am%C3%A9lie+Heinrichs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Heinrichs Amélie</a>, <a href="/search?value1=Veroniek+Saegeman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saegeman Veroniek</a>, <a href="/search?value1=Elizaveta+Padalko&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Padalko Elizaveta</a>, <a href="/search?value1=Amaryl+Lecompte&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lecompte Amaryl</a>, <a href="/search?value1=Wim+Vanden+Berghe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vanden Berghe Wim</a>, <a href="/search?value1=Chris+Kenyon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kenyon Chris</a>, <a href="/search?value1=Dorien+Van+den+Bossche&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van den Bossche Dorien</a></span>. Estimation of antimicrobial resistance of Mycoplasma genitalium, Belgium, 2022. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(7):pii=2300318. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.7.2300318" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.7.2300318</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Jun 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Aug 2023 </span> </p>
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