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Abstract

In November 2024, a case of clade Ib mpox was confirmed in Canada. Here, we describe the events that led to laboratory confirmation of clade Ib monkeypox virus (MPXV) and the public health response. Genomic analysis of the Canadian clade Ib MPXV revealed a number of APOBEC3-related mutations suggesting sustained human-to-human transmission. These findings expand the number of countries with travel-related clade Ib mpox and highlights the continued need for mpox monitoring of potential human adaptations or new transmission patterns.

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/content/10.2807/1560-7917.ES.2025.30.25.2500402
2025-06-26
2025-06-30
/content/10.2807/1560-7917.ES.2025.30.25.2500402
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References

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Molecular detection and isolation of clade Ib monkeypox virus, Canada, November 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Mable+Chan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chan Mable</a>, <a href="/search?value1=Jonathan+Audet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Audet Jonathan</a>, <a href="/search?value1=J%C3%A9r%C3%A9mie+Pr%C3%A9vost&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Prévost Jérémie</a>, <a href="/search?value1=Karla+Soriano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Soriano Karla</a>, <a href="/search?value1=Kaylie+Doan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Doan Kaylie</a>, <a href="/search?value1=Lauren+Garnett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Garnett Lauren</a>, <a href="/search?value1=Yvon+Deschambault&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deschambault Yvon</a>, <a href="/search?value1=Sarah+Medina&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Medina Sarah</a>, <a href="/search?value1=Marianne+Stefopulos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stefopulos Marianne</a>, <a href="/search?value1=Julia+Paul&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paul Julia</a>, <a href="/search?value1=Santina+Lee&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lee Santina</a>, <a href="/search?value1=Carol+Kurbis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kurbis Carol</a>, <a href="/search?value1=Bunmi+Fatoye&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fatoye Bunmi</a>, <a href="/search?value1=Ana+T+Duggan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Duggan Ana T</a>, <a href="/search?value1=Katherine+Eaton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eaton Katherine</a>, <a href="/search?value1=Connor+Chato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chato Connor</a>, <a href="/search?value1=Darian+Hole&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hole Darian</a>, <a href="/search?value1=Amber+Papineau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Papineau Amber</a>, <a href="/search?value1=Kerry+Dust&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dust Kerry</a>, <a href="/search?value1=Paul+Van+Caeseele&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Caeseele Paul</a>, <a href="/search?value1=Yonette+R+Hercules&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hercules Yonette R</a>, <a href="/search?value1=Shannon+Gearhart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gearhart Shannon</a>, <a href="/search?value1=John+Embil&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Embil John</a>, <a href="/search?value1=Andrew+Walkty&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Walkty Andrew</a>, <a href="/search?value1=Donna+Romaniuk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Romaniuk Donna</a>, <a href="/search?value1=David+Safronetz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Safronetz David</a>, <a href="/search?value1=James+E+Strong&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Strong James E</a></span>. Molecular detection and isolation of clade Ib monkeypox virus, Canada, November 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(25):pii=2500402. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.25.2500402" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.25.2500402</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 06 Jun 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 26 Jun 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.25.2500402
/content/10.2807/1560-7917.ES.2025.30.25.2500402
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