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Abstract

An investigation of the European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) detected the same mosaic IncHI1B(pNDM-MAR) resistance (OXA-48) and virulence (aerobactin) plasmid in 492 isolates from eight European Union countries during 2019–2024. Involvement of various sequence types (STs), multiple introductions, followed by large clonal outbreaks of three STs (ST147, ST392, ST45) carrying the plasmid in two countries indicate a high risk for further spread of this plasmid and a potential for difficult-to-treat infections to rise.

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/content/10.2807/1560-7917.ES.2025.30.27.2500439
2025-07-10
2025-07-12
/content/10.2807/1560-7917.ES.2025.30.27.2500439
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Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marius+Linkevicius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Linkevicius Marius</a>, <a href="/search?value1=Erik+Alm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alm Erik</a>, <a href="/search?value1=Louise+Roer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roer Louise</a>, <a href="/search?value1=Olov+Svartstr%C3%B6m&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Svartström Olov</a>, <a href="/search?value1=Maria+Dada-Olorunwa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dada-Olorunwa Maria</a>, <a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>, <a href="/search?value1=Felix+Reichert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reichert Felix</a>, <a href="/search?value1=Sophie+M%C3%B6ller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Möller Sophie</a>, <a href="/search?value1=Christina+Clarke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Clarke Christina</a>, <a href="/search?value1=Martin+Cormican&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cormican Martin</a>, <a href="/search?value1=Baiba+Niedre-Otomere&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Niedre-Otomere Baiba</a>, <a href="/search?value1=Reinis+Vangravs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vangravs Reinis</a>, <a href="/search?value1=Paulius+Grei%C4%8Dius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Greičius Paulius</a>, <a href="/search?value1=Olga+Burduniuc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Burduniuc Olga</a>, <a href="/search?value1=Maria+Anton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Anton Maria</a>, <a href="/search?value1=Antoni+P.A.+Hendrickx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hendrickx Antoni P.A.</a>, <a href="/search?value1=Sandra+Witteveen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Witteveen Sandra</a>, <a href="/search?value1=Vilhelm+M%C3%BCller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Müller Vilhelm</a>, <a href="/search?value1=Daniel+Palm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palm Daniel</a>, <a href="/search?value1=Diamantis+Plachouras&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Plachouras Diamantis</a>, <a href="/search?value1=Dominique+L.+Monnet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monnet Dominique L.</a>, <a href="/search?value1=Henrik+Hasman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasman Henrik</a>, <a href="/search?value1=Anke+Kohlenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kohlenberg Anke</a></span>. Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(27):pii=2500439. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.27.2500439" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.27.2500439</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Jun 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 10 Jul 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.27.2500439
/content/10.2807/1560-7917.ES.2025.30.27.2500439
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