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Abstract

A 6-month-old infant was hospitalised with suspected infant botulism after being given peanut butter to reduce their risk of developing peanut allergy. type A was detected in their faeces and the peanut butter by PCR and culture. Whole genome sequencing confirmed identical strains, identifying the peanut butter as the source of infection. The infant was treated with human-derived antitoxin Botulism Immune Globulin Intravenous (Human) (BIG-IV) and recovered well. This case highlights potential botulism risk with early peanut introduction.

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/content/10.2807/1560-7917.ES.2025.30.30.2500512
2025-07-31
2025-08-04
/content/10.2807/1560-7917.ES.2025.30.30.2500512
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References

  1. California Department of Public Health (CDPH). Infant Botulism Treatment and Prevention Program. Sacramento: CDPH. [Accessed: 25 Jun 2025]. Available from: https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/InfantBotulism.aspx
  2. Clay SA, Ramseyer JC, Fishman LS, Sedgwick RP. Acute infantile motor unit disorder. Infantile botulism? Arch Neurol. 1977;34(4):236-43.  https://doi.org/10.1001/archneur.1977.00500160050009  PMID: 320969 
  3. Moberg LJ, Sugiyama H. Microbial ecological basis of infant botulism as studied with germfree mice. Infect Immun. 1979;25(2):653-7.  https://doi.org/10.1128/iai.25.2.653-657.1979  PMID: 385503 
  4. Sheppard YD, Middleton D, Whitfield Y, Tyndel F, Haider S, Spiegelman J, et al. Intestinal toxemia botulism in 3 adults, Ontario, Canada, 2006-2008. Emerg Infect Dis. 2012;18(1):1-6.  https://doi.org/10.3201/eid1801.110533  PMID: 22257757 
  5. Antonucci L, Locci C, Schettini L, Clemente MG, Antonucci R. Infant botulism: an underestimated threat. Infect Dis (Lond). 2021;53(9):647-60.  https://doi.org/10.1080/23744235.2021.1919753  PMID: 33966588 
  6. Arnon SS, Schechter R, Maslanka SE, Jewell NP, Hatheway CL. Human botulism immune globulin for the treatment of infant botulism. N Engl J Med. 2006;354(5):462-71.  https://doi.org/10.1056/NEJMoa051926  PMID: 16452558 
  7. Brunt J, van Vliet AHM, Carter AT, Stringer SC, Amar C, Grant KA, et al. Diversity of the genomes and neurotoxins of strains of Clostridium botulinum group I and Clostridium sporogenes associated with foodborne, infant and wound botulism. Toxins (Basel). 2020;12(9):586.  https://doi.org/10.3390/toxins12090586  PMID: 32932818 
  8. Harris RA, Bussey J, Flint A, Blondin-Brosseau M, Weedmark K, Austin JW. Prevalence of Clostridium botulinum in retail peanut butters from a 2007 survey in Ottawa, Canada. Curr Microbiol. 2024;81(10):322.  https://doi.org/10.1007/s00284-024-03843-1  PMID: 39179697 
  9. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372(9):803-13.  https://doi.org/10.1056/NEJMoa1414850  PMID: 25705822 
  10. Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016;374(18):1733-43.  https://doi.org/10.1056/NEJMoa1514210  PMID: 26943128 
  11. Scientific Advisory Committee on Nutrition and the Committee on Toxicity of chemicals in food, consumer products and the Environment. Assessing the health benefits and risks of the introduction of peanut and hen’s egg into the infant diet before six months of age in the UK. London: United Kingdom Health Security Agency; 2018. Available from: https://www.gov.uk/government/publications/sacn-cot-statement-on-the-introduction-of-peanut-and-hens-egg-into-the-infant-diet
  12. British Society for Allergy and Clinical Immunology (BSACI). Preventing food allergy in your baby: a summary for parents. London: BSACI. [Accessed: 25 Jun 2025]. Available from: https://www.bsaci.org/wp-content/uploads/2020/02/pdf_Infant-feeding-and-allergy-prevention-PARENT-SUMMARY-FINAL.pdf
  13. Stiefel G, Anagnostou K, Boyle RJ, Brathwaite N, Ewan P, Fox AT, et al. BSACI guideline for the diagnosis and management of peanut and tree nut allergy. Clin Exp Allergy. 2017;47(6):719-39.  https://doi.org/10.1111/cea.12957  PMID: 28836701 
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