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Cross-border investigation of a tuberculosis outbreak in Vienna linked to a multi-country cluster among foreign-born individuals, Europe, 2021 to 2025
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Fiona Költringer1,*
, Maria Koreny2,*
, Dirk Werber1
, Florian Heger3
, Alena Chalupka1
, Sabine Schweiger1 , Georg Brunner2 , Ursula Tuch2 , Ursula Karnthaler2 , Senia Rosales Klintz4
, Csaba Ködmön4
, Andreas Hoefer4
, Richard Anthony5
, Stefan Kroeger6
, Teresa Domaszewska6
, Lena Boes6
, Stefan Niemann7
, Teresa Walz7
, Martin Kuhns7
, Sarah Jackson8
, Margaret Fitzgibbon9
, Vanessa Mathys10
, Vinciane Sizaire11 , Daniela Maria Cirillo12
, Monica Sane Schepisi13
, Janne Oseberg Rønning14
, Laura Herrera-Leon15
, Pere-Joan Cardona16
, Ramona Groenheit17
, Mikael Mansjö17
, Viktória Szél18 , Erik Alm4,**
, Adriana Cabal1,**
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View Affiliations Hide AffiliationsAffiliations: 1 Institute for Infectious Disease Epidemiology, Austrian Agency for Health and Food Safety, Vienna, Austria 2 Tuberculosis Prevention and Control, Public Health Services, City of Vienna, Austria 3 National Reference Centre for Tuberculosis, Institute for Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, Vienna, Austria 4 European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden 5 Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands 6 Infectious Disease Epidemiology Department, Robert Koch Institute, Berlin, Germany 7 Research Center Borstel, National Reference Center for Mycobacteria, and Molecular and Experimental Mycobacteriology, Borstel, Germany 8 Health Protection Surveillance Centre, Health Service Executive, Dublin, Ireland 9 Irish Mycobacteria Reference Laboratory, St James’s Hospital, Dublin, Ireland 10 National Reference Centre Mycobacterium, Bacterial Diseases Service, Sciensano, Brussels, Belgium 11 Fonds des Affections Respiratoires (FARES), Brussels, Belgium 12 Reference Laboratory for Tuberculosis Molecular Surveillance, IRCCS San Raffaele Scientific Institute, Milan, Italy 13 Italian Ministry of Health, General Directorate for Health Prevention, Rome, Italy 14 Norwegian Institute of Public Health, Department of Bacteriology, National Reference Laboratory for Mycobacteria, Oslo, Norway 15 National Reference Laboratory for Mycobacteriology, National Microbiology Centre - Carlos III Institute of Health, Madrid, Spain 16 Servei de Microbiologia, Laboratori Clínic Metropolitana Nord. Hospital Germans Trias i Pujol, Badalona, Catalonia, Spain 17 Public Health Agency of Sweden, Stockholm, Sweden 18 National Reference Laboratory for Mycobacteriology, Korányi National Institute for Tuberculosis and Respiratory Medicine, Budapest, Hungary* These authors contributed equally to this article and share first authorship** These authors contributed equally to this article and share last authorshipCorrespondence:Fiona Költringerfiona.koeltringer ages.at
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View Citation Hide Citation
Citation style for this article: Költringer Fiona, Koreny Maria, Werber Dirk, Heger Florian, Chalupka Alena, Schweiger Sabine, Brunner Georg, Tuch Ursula, Karnthaler Ursula, Klintz Senia Rosales, Ködmön Csaba, Hoefer Andreas, Anthony Richard, Kroeger Stefan, Domaszewska Teresa, Boes Lena, Niemann Stefan, Walz Teresa, Kuhns Martin, Jackson Sarah, Fitzgibbon Margaret, Mathys Vanessa, Sizaire Vinciane, Cirillo Daniela Maria, Sane Schepisi Monica, Rønning Janne Oseberg, Herrera-Leon Laura, Cardona Pere-Joan, Groenheit Ramona, Mansjö Mikael, Szél Viktória, Alm Erik, Cabal Adriana. Cross-border investigation of a tuberculosis outbreak in Vienna linked to a multi-country cluster among foreign-born individuals, Europe, 2021 to 2025. Euro Surveill. 2025;30(33):pii=2500565. https://doi.org/10.2807/1560-7917.ES.2025.30.33.2500565 Received: 01 Aug 2025; Accepted: 21 Aug 2025
Abstract
Collaborative genomic and epidemiological investigations identified a tuberculosis outbreak in Vienna as part of a multi-country cluster comprising 57 foreign-born cases of Mycobacterium tuberculosis ST215/Beijing 2.2.1 notified 2021–2025. While 14 of 16 cases in Vienna were considered autochthonous, the diverse geographic origin of clustered cases across nine European countries suggests a common transmission source, possibly linked to migratory routes. Cross-border data exchange and integrated genomic analysis are essential for identifying transmission dynamics in tuberculosis clusters affecting mobile populations.

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