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2025 theme: Vaccines

Abstract

BACKGROUND

Pertussis is a highly contagious respiratory infection caused by . Vaccination against pertussis is included in the Italian vaccination programme with three doses administered at 3, 5 and 11 months, booster doses at 6 and 12–18 years, and every 10 years. Vaccination coverage in Tuscany is high among infants (97.7% vs 94.7% national average at 24 months) and adolescents (75.8% vs 68.4% national average at 16 years).

AIM

We aimed to investigate case numbers, vaccination status and time points for vaccination of children and adolescents hospitalised for pertussis.

METHODS

We collected data on children and adolescents aged ≤ 16 years and hospitalised for laboratory-confirmed pertussis in 2016–2024 at a tertiary hospital in Tuscany.

RESULTS

A total of 384 children and adolescents were hospitalised in 2016–2024. Annual case numbers increased from an average of 28.2 cases in 2016–2019 to 259 cases in 2024, with 136 (52.5%) cases in adolescents. Of the 107 cases aged 12–16 years, 93 (86.9%) were unvaccinated or had not received the second booster. A considerable time gap between the earliest eligible day for vaccination and hospitalisation was observed. In infants, a median of 31 days (interquartile range (IQR): 10–131 days) was noticed for the first dose, 44 days (IQR: 22–70 days) for the second and 53 days for the third. In 12–16-year-olds, a median of 395 days (IQR: 236–717) was seen for the second booster.

CONCLUSION

Administering adolescent booster doses earlier, vaccinating at the earliest eligible time points, and promoting timely vaccination through targeted communication campaigns may reduce pertussis-related hospitalisations.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2025-08-28
2025-08-29
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References

  1. Carloni I, Ricci S, Azzari C, Galletti S, Faldella G, de Benedictis FM. Fatal pertussis in infancy, Italy. J Infect. 2017;75(2):186-9.  https://doi.org/10.1016/j.jinf.2017.04.005  PMID: 28438536 
  2. Hitz DA, Tewald F, Eggers M. Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany. BMC Infect Dis. 2020;20(1):474.  https://doi.org/10.1186/s12879-020-05199-w  PMID: 32620085 
  3. Ministero della Salute. Vaccinazioni dell’età pediatrica e dell’adolescenza – coperture vaccinali. [Childhood vaccinations – vaccination coverage]. Rome: Ministero della Salute; 27 Feb 2025. Italian. Available from: https://www.salute.gov.it/portale/documentazione/p6_2_8_1_1.jsp?lingua=italiano&id=38
  4. European Centre for Disease Prevention and Control (ECDC). Increase of pertussis cases in the EU/EEA. Stockholm: ECDC; 8 May 2024. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Increase%20in%20pertussis%20cases%20in%20the%20EU-EEA%20-%20May%202024%20FINAL.pdf
  5. Merdrignac L, Aït El Belghiti F, Pandolfi E, Jané M, Murphy J, Fabiánová K, et al. Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018. Euro Surveill. 2021;26(4):1900762.  https://doi.org/10.2807/1560-7917.ES.2021.26.4.1900762  PMID: 33509338 
  6. van de Berg S, Charles T, Dörre A, Katz K, Böhm S. Epidemiology of common infectious diseases before and during the COVID-19 pandemic in Bavaria, Germany, 2016 to 2021: an analysis of routine surveillance data. Euro Surveill. 2023;28(41):2300030.  https://doi.org/10.2807/1560-7917.ES.2023.28.41.2300030  PMID: 37824248 
  7. Medina-Marino A, Reynolds D, Finley C, Hays S, Jones J, Soyemi K. Communication and mass vaccination strategies after pertussis outbreak in rural Amish communities-Illinois, 2009-2010. J Rural Health. 2013;29(4):413-9.  https://doi.org/10.1111/jrh.12019  PMID: 24088215 
  8. Spokes PJ, Rosewell AE, Stephens AS, McAnulty JM. A state-wide information campaign during a pertussis epidemic in New South Wales, 2010. Commun Dis Intell. 2014;38(3):E201-7.  https://doi.org/10.33321/cdi.2014.38.36  PMID: 25391406 
  9. Ministry of Health. Whooping cough epidemic declared across Aotearoa New Zealand. Wellington: Ministry of Health; 22 Nov 2024. Available from: https://www.health.govt.nz/news/whooping-cough-epidemic-declared-across-aotearoa-new-zealand
  10. Private Care Sheffield (PCS). It’s Not Too Late- Whooping Cough Vaccination Campaign GP Communications Toolkit. Sheffield: PCS; 4 Jun 2024. Available from: https://primarycaresheffield.org.uk/wp-content/uploads/2024/06/PCS-Its-Not-Too-Late-GP-Communications-Toolkit.pdf
  11. European Centre for Disease Prevention and Control (ECDC). Laboratory diagnosis and molecular surveillance of Bordetella pertussis. Stockholm: ECDC; 21 Dec 2022. Available from: https://www.ecdc.europa.eu/en/publications-data/bordetella-pertussis-laboratory-diagnosis-and-molecular-surveillance
  12. Guarnieri V, Giovannini M, Lodi L, Astorino V, Pisano L, Di Cicco E, et al. Severe pertussis disease in a paediatric population: The role of age, vaccination status and prematurity. Acta Paediatr. 2022;111(9):1781-7.  https://doi.org/10.1111/apa.16436  PMID: 35638439 
  13. Nordholm AC, Emborg HD, Nørgaard SK, Nygaard U, Ronayne A, Nielsen LB, et al. Pertussis epidemic in Denmark, August 2023 to February 2024. Euro Surveill. 2024;29(14):2400160.  https://doi.org/10.2807/1560-7917.ES.2024.29.14.2400160  PMID: 38577803 
  14. Poltorak V, Cabré-Riera A, Martínez-Botías F, Borràs López E, Clotet Romero L, Sala Farré MR, et al. Increase of pertussis cases in the Vallès region, Catalonia, Spain, September 2023 to April 2024. Euro Surveill. 2024;29(24):2400332.  https://doi.org/10.2807/1560-7917.ES.2024.29.24.2400332  PMID: 38873794 
  15. Rodrigues C, Bouchez V, Soares A, Trombert-Paolantoni S, Aït El Belghiti F, Cohen JF, et al. Resurgence of Bordetella pertussis, including one macrolide-resistant isolate, France, 2024. Euro Surveill. 2024;29(31):2400459.  https://doi.org/10.2807/1560-7917.ES.2024.29.31.2400459  PMID: 39092529 
  16. Poeta M, Moracas C, Albano C, Petrarca L, Maglione M, Pierri L, et al. Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies. Euro Surveill. 2024;29(23):2400301.  https://doi.org/10.2807/1560-7917.ES.2024.29.23.2400301  PMID: 38847118 
  17. Prevost B, Nathan N, Corvol H. Letter to the editor: Is the acellular pertussis vaccine driving the increase in severe whooping cough cases in children? Euro Surveill. 2024;29(37):2400574.  https://doi.org/10.2807/1560-7917.ES.2024.29.37.2400574  PMID: 39268650 
  18. Ma L, Caulfield A, Dewan KK, Harvill ET. Pertactin-deficient Bordetella pertussis, vaccine-driven evolution, and reemergence of pertussis. Emerg Infect Dis. 2021;27(6):1561-6.  https://doi.org/10.3201/eid2706.203850  PMID: 34014152 
  19. Khalil A, Samara A, Campbell H, Ladhani SN, Amirthalingam G. Recent increase in infant pertussis cases in Europe and the critical importance of antenatal immunizations: We must do better…now. Int J Infect Dis. 2024;146:107148.  https://doi.org/10.1016/j.ijid.2024.107148  PMID: 38960028 
  20. Parisi A, Nuñez O, López-Perea N, Masa-Calles J. Reduced pertussis disease severity in infants following the introduction of pertussis vaccination of pregnant women in Spain, 2015-2019. Vaccine. 2024;42(11):2810-6.  https://doi.org/10.1016/j.vaccine.2024.03.028  PMID: 38531728 
Bordetella pertussis in hospitalised children and adolescents: the impact of vaccination delay, Tuscany, Italy, 2016 to 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Francesco+Nieddu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nieddu Francesco</a>, <a href="/search?value1=Francesca+Quaranta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quaranta Francesca</a>, <a href="/search?value1=Marina+Vignoli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vignoli Marina</a>, <a href="/search?value1=Matilde+Peri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peri Matilde</a>, <a href="/search?value1=Valentina+Guarnieri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guarnieri Valentina</a>, <a href="/search?value1=Caterina+Pelosi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pelosi Caterina</a>, <a href="/search?value1=Emanuela+Ferraro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferraro Emanuela</a>, <a href="/search?value1=Lorenzo+Lodi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lodi Lorenzo</a>, <a href="/search?value1=Silvia+Ricci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ricci Silvia</a>, <a href="/search?value1=Giuseppe+Indolfi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Indolfi Giuseppe</a>, <a href="/search?value1=Chiara+Azzari&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Azzari Chiara</a>, <a href="/search?value1=Maria+Moriondo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moriondo Maria</a></span>. Bordetella pertussis in hospitalised children and adolescents: the impact of vaccination delay, Tuscany, Italy, 2016 to 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(34):pii=2500062. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.34.2500062" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.34.2500062</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 17 Jan 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 13 May 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.34.2500062
/content/10.2807/1560-7917.ES.2025.30.34.2500062
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