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Abstract

We report the emergence and evolution of a circulating vaccine-derived poliovirus type 1 (cVDPV1) outbreak in Israel, linked to a vaccine-associated paralytic poliomyelitis case. Whole genome sequencing revealed a strong genetic link between the Sabin-like poliovirus type 1 variant from the case and pre-VDPV1 and VDPV1 isolated from environmental samples collected in October 2024–April 2025, mostly in Jerusalem. Early detection was made possible by Israel’s robust environmental surveillance and advanced sequencing technologies, enabling a rapid public health response.

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/content/10.2807/1560-7917.ES.2025.30.34.2500605
2025-08-28
2025-09-03
/content/10.2807/1560-7917.ES.2025.30.34.2500605
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Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Neta+S+Zuckerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zuckerman Neta S</a>, <a href="/search?value1=Yaniv+Lustig&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lustig Yaniv</a>, <a href="/search?value1=Danit+Sofer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sofer Danit</a>, <a href="/search?value1=Lester+M+Shulman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shulman Lester M</a>, <a href="/search?value1=Leah+Weiss&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Weiss Leah</a>, <a href="/search?value1=Rinat+Vasserman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vasserman Rinat</a>, <a href="/search?value1=Reut+Gabai&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gabai Reut</a>, <a href="/search?value1=Keren+Friedman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Friedman Keren</a>, <a href="/search?value1=Hagar+Eliyahu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eliyahu Hagar</a>, <a href="/search?value1=Noa+Bar-Liss&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bar-Liss Noa</a>, <a href="/search?value1=Tatyana+Kushnir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kushnir Tatyana</a>, <a href="/search?value1=Ira+Aguvaev&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aguvaev Ira</a>, <a href="/search?value1=Tal+Butensky&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Butensky Tal</a>, <a href="/search?value1=Daniel+Avhar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Avhar Daniel</a>, <a href="/search?value1=Alex+Aydenzon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aydenzon Alex</a>, <a href="/search?value1=Oran+Erster&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Erster Oran</a>, <a href="/search?value1=Itay+Bar-Or&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bar-Or Itay</a>, <a href="/search?value1=Merav+Weil&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Weil Merav</a></span>. Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(34):pii=2500605. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.34.2500605" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.34.2500605</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 08 Aug 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 27 Aug 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.34.2500605
/content/10.2807/1560-7917.ES.2025.30.34.2500605
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