Recent evidence of underestimated circulation of hepatitis C virus intergenotypic recombinant strain RF2k/1b in the Rhône-Alpes region, France, January to August 2014: implications for antiviral treatment

C Ramière; P Tremeaux; A Caporossi; M A Trabaud; F Lebossé; F Bailly; M A Thélu; J Nana; V Leroy; P Morand; P André; S Larrat

doi:10.2807/1560-7917.ES2014.19.43.20944

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Recent evidence of underestimated circulation of hepatitis C virus intergenotypic recombinant strain RF2k/1b in the Rhône-Alpes region, France, January to August 2014: implications for antiviral treatment
C Ramière^1,2,3 , P Tremeaux^4,5 , A Caporossi⁵ , M A Trabaud¹ , F Lebossé^2,6,7 , F Bailly⁶ , M A Thélu⁸ , J Nana⁸ , V Leroy⁸ , P Morand^4,5 , P André^1,2,3 , S Larrat^4,5
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Affiliations: ¹ Laboratoire de Virologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France ² Université de Lyon, Lyon, France ³ CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France ⁴ Laboratoire de Virologie, Pôle Biologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France ⁵ Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, Grenoble, France ⁶ Service d’Hépato-Gastroentérologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France ⁷ INSERM U1052, CRCL (Centre de recherche en cancérologie de Lyon), Lyon, France ⁸ Clinique Universitaire d’Hépato-gastroentérologie, Pôle Digidune, Centre Hospitalier Universitaire Grenoble, France

Correspondence:
C Ramière
christophe.ramiere chu-lyon.fr
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Citation style for this article: Ramière C, Tremeaux P, Caporossi A, Trabaud M A, Lebossé F, Bailly F, Thélu M A, Nana J, Leroy V, Morand P, André P, Larrat S. Recent evidence of underestimated circulation of hepatitis C virus intergenotypic recombinant strain RF2k/1b in the Rhône-Alpes region, France, January to August 2014: implications for antiviral treatment. Euro Surveill. 2014;19(43):pii=20944. https://doi.org/10.2807/1560-7917.ES2014.19.43.20944 Received: 26 Sept 2014

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Abstract

Since the beginning of 2014, hepatitis C virus (HCV) recombinant forms RF2k/1b have been detected in the Rhône-Alpes French region in 10 patients originating from the Caucasus area. Circulation of this particular HCV strain is very likely to be underestimated. It is also prone to be misgenotyped when using genotyping methods based on the 5' region of the viral genome, which may lead to suboptimal treatment. .