Afebrile meningoencephalitis with transient central facial paralysis due to Toscana virus infection, south-eastern France, 2014

M C Marlinge; L Crespy; C Zandotti; G Piorkowski; E Kaphan; R N Charrel; L Ninove

doi:10.2807/1560-7917.ES2014.19.48.20974

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Afebrile meningoencephalitis with transient central facial paralysis due to Toscana virus infection, south-eastern France, 2014
M C Marlinge¹ , L Crespy² , C Zandotti^1,3 , G Piorkowski^1,3 , E Kaphan² , R N Charrel^1,3 , L Ninove^1,3
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Affiliations: ¹ IHU Méditerranée Infection, APHM Public Hospitals of Marseille, Marseille, France ² Department of Clinical Neurosciences, Unit of Neurology, AP-HM Timone Hospital, Marseille, France ³ Aix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health, EPV UMR_D 190 "Emergence des Pathologies Virales", Marseille, France

Correspondence:
R Charrel
remi.charrel univ-amu.fr
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Citation style for this article: Marlinge M C, Crespy L, Zandotti C, Piorkowski G, Kaphan E, Charrel R N, Ninove L. Afebrile meningoencephalitis with transient central facial paralysis due to Toscana virus infection, south-eastern France, 2014. Euro Surveill. 2014;19(48):pii=20974. https://doi.org/10.2807/1560-7917.ES2014.19.48.20974 Received: 14 Nov 2014

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Abstract

We report a case of meningoencephalitis caused by Toscana virus (TOSV) with central facial paralysis lasting over two days acquired in south-eastern France. The patient was not febrile either before or during the course of the disease. The diagnosis was established by both real-time RT-PCR and virus isolation with complete genome sequencing. This case emphasises the need to consider TOSV in non-febrile neurological syndromes in people living in or having travelled to the Mediterranean area.