Most but not all laboratories can detect the recently emerged Neisseria gonorrhoeae porA mutants – results from the QCMD 2013 N. gonorrhoeae external quality assessment programme

D Luijt; C Di Lorenzo; A M van Loon; M Unemo

doi:10.2807/1560-7917.ES2014.19.8.20711

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Most but not all laboratories can detect the recently emerged Neisseria gonorrhoeae porA mutants – results from the QCMD 2013 N. gonorrhoeae external quality assessment programme
D Luijt¹ , C Di Lorenzo² , A M van Loon² , M Unemo³
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Affiliations: ¹ Certe, Department of Medical Microbiology, Groningen, the Netherlands ² Quality Control for Molecular Diagnostics, Glasgow, Scotland, United Kingdom ³ WHO Collaborating Centre for Gonorrhoea and other STIs, Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden

Correspondence:
D Luijt
d.luijt infectielab.nl
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Citation style for this article: Luijt D, Di Lorenzo C, van Loon A M, Unemo M. Most but not all laboratories can detect the recently emerged Neisseria gonorrhoeae porA mutants – results from the QCMD 2013 N. gonorrhoeae external quality assessment programme . Euro Surveill. 2014;19(8):pii=20711. https://doi.org/10.2807/1560-7917.ES2014.19.8.20711 Received: 06 Feb 2014

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Abstract

We describe the results of the Quality Control for Molecular Diagnostics 2013 Neisseria gonorrhoeae external quality assessment programme that included an N. gonorrhoeae strain harbouring an N. meningitidis porA gene which causes false-negative results in molecular diagnostic assays targeting the gonococcal porA pseudogene. Enhanced awareness of the international transmission of such gonococcal strains is needed to avoid false-negative results in both in-house and commercial molecular diagnostic assays used in laboratories worldwide, but particularly in Europe.