Impact of 10- and 13-valent pneumococcal conjugate vaccines on incidence of invasive pneumococcal disease in children aged under 16 years in Germany, 2009 to 2012

We assessed the impact of 10-valent and 13-valent pneumococcal vaccines (PCV10 and PCV13), which were introduced in Germany in 2009, on the incidence of meningitis and non-meningitis invasive pneumococcal disease (IPD) in children aged?under?16 years in a population previously vaccinated with a seven-valent vaccine (PCV7). Surveillance of IPD (isolation of Streptococcus pneumonia from a normally sterile body site) is based on data from two independent reporting sources: hospitals and laboratories. IPD incidence was estimated by capture-recapture analysis. Incidence rate ratios (IRRs) were calculated for 2009 and 2012, thus comparing pre- and post-PCV10 and PCV13 data. IPD incidence caused by serotypes included in PCV13 decreased in all age and diagnosis groups. A rise in non-vaccine serotype incidence was seen only in children?aged under two years. The overall impact varied by age group and infection site: for meningitis IPD in children?aged under?2, 2-4 and 5-15 years, incidence changed by?3% (95% CI: ?31 to?52), ?60% (95% CI: ?81 to ?17) and ?9% (95% CI: ?46 to?53), respectively. A more pronounced incidence reduction was observed for non-meningitis IPD: ?30% (95% CI: ?46 to ?7), ?39% (95% CI: ?54 to ?20) and ?83% (95% CI: ?89 to ?73) in children?aged under?2, 2-4 and 5-15 years, respectively. A higher tropism of the additional serotypes for non-meningitis IPD may be a potential explanation. The heterogeneous findings emphasise the need for rigorous surveillance. .