Anal human papillomavirus and HIV: A cross-sectional study among men who have sex with men in Moscow, Russia, 2012–2013

A L Wirtz; C E Zelaya; A Peryshkina; I McGowan; R D Cranston; C Latkin; N Galai; V Mogilniy; P Dzhigun; I Kostetskaya; C Beyrer

doi:10.2807/1560-7917.ES2015.20.15.21095

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Anal human papillomavirus and HIV: A cross-sectional study among men who have sex with men in Moscow, Russia, 2012–2013

A L Wirtz^1,2, C E Zelaya^2,3, A Peryshkina⁴, I McGowan⁵, R D Cranston⁶, C Latkin⁷, N Galai^2,3, V Mogilniy⁴, P Dzhigun⁴, I Kostetskaya⁴, C Beyrer^2,3
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Affiliations: ¹ Department of Emergency Medicine, Johns Hopkins Medical Institute, Baltimore, MD, United States ² Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States ³ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States ⁴ AIDS Infoshare, Moscow, Russian Federation ⁵ University of Pittsburgh School of Medicine, Magee Women's Research Institute, Pittsburgh, PA, United States ⁶ Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, United States ⁷ Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States

Correspondence:
A Wirtz
awirtz1 jhu.edu
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Citation style for this article: Wirtz A L, Zelaya C E, Peryshkina A, McGowan I, Cranston R D, Latkin C, Galai N, Mogilniy V, Dzhigun P, Kostetskaya I, Beyrer C. Anal human papillomavirus and HIV: A cross-sectional study among men who have sex with men in Moscow, Russia, 2012–2013. Euro Surveill. 2015;20(15):pii=21095. https://doi.org/10.2807/1560-7917.ES2015.20.15.21095 Received: 30 Aug 2014

Abstract

Anal human papillomavirus (HPV) is prevalent among men who have sex with men (MSM), but has not been studied in the Russian Federation. A cross-sectional survey and HPV genotyping were conducted among HIV seropositive (n=58) and seronegative MSM (n=65) in Moscow. Multivariable logistic regression was performed to identify correlates of infection with oncogenic HPV genotypes 16 and/or 18 (HPV 16/18). Forty per cent (49/124) of all MSM were infected with at least one anal HPV genotype, 31.5% (39/124) had HPV16/18, and 11.5% (14/121) had high-grade squamous intraepithelial lesions (HSIL). HPV 16/18 was more prevalent in HIV seropositive than seronegative men (24/58, 41.4% vs 15/65, 23.1%; p=0.03). HIV infection was independently associated with HPV 16/18 (adjusted odds ratio (AOR): 5.08; 95% confidence intervals (CI): 1.49-17.34, p=0.01), as was having 2-4 steady male sex partners in the last year (vs ≤ 1 partner; AOR: 6.99; 95%CI: 1.94-25.24, p<0.01). History of prison/detention, migration to/within Russia and use of incompatible lubricants were marginally associated with HPV 16/18 (p<0.10). Comprehensive prevention options are needed to address HIV and HPV infection among MSM in Russia and may benefit from inclusion of young men in piloted HPV vaccination programmes. .