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Missed diagnosis of influenza B virus due to nucleoprotein sequence mutations, Singapore, April 2011
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View Affiliations Hide AffiliationsJ Tangjulian_wt_tang nuhs.edu.sg
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Citation style for this article: . Missed diagnosis of influenza B virus due to nucleoprotein sequence mutations, Singapore, April 2011 . Euro Surveill. 2011;16(33):pii=19943. https://doi.org/10.2807/ese.16.33.19943-en Received: 08 Aug 2011
Abstract
A new influenza B variant was discovered in Singapore in April 2011 during diagnostic testing of a 3-year-old boy with respiratory symptoms. Influenza B virus was isolated from culture and confirmed by standard immunofluorescence testing, but was not detected by the routine, in-house influenza screening reverse-transcription polymerase chain reaction assay that targets the nucleoprotein (NP) gene. Subsequent sequencing investigations demonstrated that several other published assays targeting NP could also fail to detect this novel variant.
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