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Abstract

Atypical clinical presentations associated with group W meningococcal disease (MenW) are well-described and include pneumonia, septic arthritis, endocarditis and epiglottitis/supraglottitis. Following anecdotal reports of teenagers presenting with predominantly gastrointestinal symptoms, we undertook a case review of MenW cases in 15 to 19 year-olds diagnosed in England between July 2015 and January 2016. Of the 15 cases, seven presented with a short history of nausea, vomiting and diarrhoea; five of these seven cases died within 24 hours of presentation to hospital.

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/content/10.2807/1560-7917.ES.2016.21.12.30175
2016-03-24
2022-09-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.12.30175
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References

  1. Campbell H, Saliba V, Borrow R, Ramsay M, Ladhani SN. Targeted vaccination of teenagers following continued rapid endemic expansion of a single meningococcal group W clone (sequence type 11 clonal complex), United Kingdom 2015. Euro Surveill. 2015;20(28):21188.  https://doi.org/10.2807/1560-7917.ES2015.20.28.21188  PMID: 26212140 
  2. Ladhani SN, Beebeejaun K, Lucidarme J, Campbell H, Gray S, Kaczmarski E, et al. Increase in endemic Neisseria meningitidis capsular group W sequence type 11 complex associated with severe invasive disease in England and Wales. Clin Infect Dis. 2015;60(4):578-85.  https://doi.org/10.1093/cid/ciu881  PMID: 25389259 
  3. Ladhani SN, Ramsay M, Borrow R, Riordan A, Watson JM, Pollard AJ. Enter B and W: two new meningococcal vaccine programmes launched. Arch Dis Child. 2016;101(1):91-5.  https://doi.org/10.1136/archdischild-2015-308928  PMID: 26672098 
  4. Lucidarme J, Hill DM, Bratcher HB, Gray SJ, du Plessis M, Tsang RS, et al. Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage. J Infect. 2015;71(5):544-52.  https://doi.org/10.1016/j.jinf.2015.07.007  PMID: 26226598 
  5. Thompson MJ, Ninis N, Perera R, Mayon-White R, Phillips C, Bailey L, et al. Clinical recognition of meningococcal disease in children and adolescents. Lancet. 2006;367(9508):397-403.  https://doi.org/10.1016/S0140-6736(06)67932-4  PMID: 16458763 
  6. Greenwood B. Meningococcal meningitis in Africa. Trans R Soc Trop Med Hyg. 1999;93(4):341-53.  https://doi.org/10.1016/S0035-9203(99)90106-2  PMID: 10674069 
  7. Odegaard A. Unusual manifestations of meningococcal infection. A review. NIPH Ann. 1983;6(1):59-63. PMID: 6413905 
  8. Hussein A, Naschitz Y, Yeshurun D. [Fulminant meningococcemia presenting as a gastroenteritis-like syndrome]. Harefuah. 1999;137(9):371-2, 431. Hebrew. PMID: 11419036 
  9. Moreno G, López D, Vergara N, Gallegos D, Advis MF, Loayza S. Caracterización clínica de los casos de enfermedad meningocóccica por serogrupo W135 confirmados durante el año 2012 en Chile. [Clinical characterization of cases with meningococcal disease by W135 group in Chile, 2012]. Rev Chilena Infectol. 2013;30(4):350-60. Spanish. PMID: 24248103 
  10. Gedde-Dahl TW, Bjark P, Høiby EA, Høst JH, Bruun JN. Severity of meningococcal disease: assessment by factors and scores and implications for patient management. Rev Infect Dis. 1990;12(6):973-92.  https://doi.org/10.1093/clinids/12.6.973  PMID: 2267493 
  11. Tønjum T, Nilsson F, Bruun JN, Haneberg B. The early phase of meningococcal disease. NIPH Ann. 1983;6(2):175-81. PMID: 6676683 
  12. Almond S, Mant D, Thompson M. Diagnostic safety-netting. Br J Gen Pract. 2009;59(568):872-4, discussion 874.  https://doi.org/10.3399/bjgp09X472971  PMID: 19861036 
Presentation with gastrointestinal symptoms and high case fatality associated with group W meningococcal disease (MenW) in teenagers, England, July 2015 to January 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Helen+Campbell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Campbell Helen</a>, <a href="/search?value1=Sydel+R+Parikh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Parikh Sydel R</a>, <a href="/search?value1=Ray+Borrow&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Borrow Ray</a>, <a href="/search?value1=Ed+Kaczmarski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kaczmarski Ed</a>, <a href="/search?value1=Mary+E+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Mary E</a>, <a href="/search?value1=Shamez+N+Ladhani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ladhani Shamez N</a></span>. Presentation with gastrointestinal symptoms and high case fatality associated with group W meningococcal disease (MenW) in teenagers, England, July 2015 to January 2016. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(12):pii=30175. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.12.30175" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.12.30175</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Mar 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 24 Mar 2016 </span> </p>
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