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We report an increase of serogroup C invasive meningococcal disease in Tuscany. From January 2015 to end February 2016, 43 cases were reported, among which 10 were fatal, compared to two cases caused by serogroup C recorded in 2014 and three in 2013. No secondary cases occurred. Thirty–five strains belonged to C:P1.5–1,10–8:F3–6:ST-11(cc11). Control measures have been adopted and immunisation campaigns implemented. Studies on risk factors and carriage are ongoing.


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  1. Italian National Health Institute. (Istituto Superiore di Sanità, ISS). Dati di sorveglianza delle malattie batteriche invasive aggiornati al 23 dicembre 2015. [Surveillance data on invasive bacterial diseases updated on 23 December 2015]. Italian. Available from: http://www.iss.it/binary/mabi/cont/Report_MBI_20151223_v4.pdf
  2. Ishola DA Jr, Borrow R, Findlow H, Findlow J, Trotter C, Ramsay ME. Prevalence of serum bactericidal antibody to serogroup C Neisseria meningitidis in England a decade after vaccine introduction. Clin Vaccine Immunol. 2012;19(8):1126-30.  https://doi.org/10.1128/CVI.05655-11  PMID: 22647271 
  3. Watkins ER, Maiden MC. Persistence of hyperinvasive meningococcal strain types during global spread as recorded in the PubMLST database. PLoS One. 2012;7(9):e45349.  https://doi.org/10.1371/journal.pone.0045349  PMID: 23028953 
  4. Smith I, Caugant DA, Høiby EA, Wentzel-Larsen T, Halstensen A. High case-fatality rates of meningococcal disease in Western Norway caused by serogroup C strains belonging to both sequence type (ST)-32 and ST-11 complexes, 1985-2002. Epidemiol Infect. 2006;134(6):1195-202.  https://doi.org/10.1017/S0950268806006248  PMID: 16650328 
  5. Marcus U, Vogel U, Schubert A, Claus H, Baetzing-Feigenbaum J, Hellenbrand W, et al. A cluster of invasive meningococcal disease in young men who have sex with men in Berlin, October 2012 to May 2013. Euro Surveill. 2013;18(28):20523.  https://doi.org/10.2807/1560-7917.ES2013.18.28.20523  PMID: 23870095 
  6. Aubert L, Taha M, Boo N, Le Strat Y, Deghmane AE, Sanna A, et al. Serogroup C invasive meningococcal disease among men who have sex with men and in gay-oriented social venues in the Paris region: July 2013 to December 2014. Euro Surveill. 2015;20(3):21016.  https://doi.org/10.2807/1560-7917.ES2015.20.3.21016  PMID: 25635319 
  7. Stefanelli P, Fazio C, Neri A, Isola P, Sani S, Marelli P, et al. Cluster of invasive Neisseria meningitidis infections on a cruise ship, Italy, October 2012. Euro Surveill. 2012;17(50):20336. PMID: 23241233 
  8. Stefanelli P, Fazio C, Sofia T, Neri A, Mastrantonio P. Serogroup C meningococci in Italy in the era of conjugate menC vaccination. BMC Infect Dis. 2009;9(1):135.  https://doi.org/10.1186/1471-2334-9-135  PMID: 19698137 
  9. Italian Ministry of Health. Piano Nazionale. Prevenzione Vaccinale. (PNPV) 2012 – 2014. [National Vaccination Prevention Plan 2012-2014]. Italian Available from: http://www.salute.gov.it/imgs/c_17_pubblicazioni_1721_allegato.pdf
  10. European Centre for Disease Prevention and Control (ECDC). Public health management of sporadic cases of invasive meningococcal disease and their contacts. Stockholm: ECDC; 2010. Available from: http://ecdc.europa.eu/en/publications/Publications/1010_GUI_Meningococcal_guidance.pdf

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