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Abstract

During the 2009/10 influenza A(H1N1)pdm09 pandemic, the five Nordic countries adopted different approaches to pandemic vaccination. We compared pandemic vaccination strategies and severe influenza outcomes, in seasons 2009/10 and 2010/11 in these countries with similar influenza surveillance systems. We calculated the cumulative pandemic vaccination coverage in 2009/10 and cumulative incidence rates of laboratory confirmed A(H1N1)pdm09 infections, intensive care unit (ICU) admissions and deaths in 2009/10 and 2010/11. We estimated incidence risk ratios (IRR) in a Poisson regression model to compare those indicators between Denmark and the other countries. The vaccination coverage was lower in Denmark (6.1%) compared with Finland (48.2%), Iceland (44.1%), Norway (41.3%) and Sweden (60.0%). In 2009/10 Denmark had a similar cumulative incidence of A(H1N1)pdm09 ICU admissions and deaths compared with the other countries. In 2010/11 Denmark had a significantly higher cumulative incidence of A(H1N1)pdm09 ICU admissions (IRR: 2.4; 95% confidence interval (CI): 1.9–3.0) and deaths (IRR: 8.3; 95% CI: 5.1–13.5). Compared with Denmark, the other countries had higher pandemic vaccination coverage and experienced less A(H1N1)pdm09-related severe outcomes in 2010/11. Pandemic vaccination may have had an impact on severe influenza outcomes in the post-pandemic season. Surveillance of severe outcomes may be used to compare the impact of influenza between seasons and support different vaccination strategies.

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/content/10.2807/1560-7917.ES.2016.21.16.30208
2016-04-21
2024-09-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.16.30208
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Pandemic vaccination strategies and influenza severe outcomes during the influenza A(H1N1)pdm09 pandemic and the post-pandemic influenza season: the Nordic experience
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Julita++Gil+Cuesta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gil Cuesta Julita </a>, <a href="/search?value1=Preben+Aavitsland&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aavitsland Preben</a>, <a href="/search?value1=H%C3%A9l%C3%A8ne+Englund&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Englund Hélène</a>, <a href="/search?value1=%C3%93lafur+Gudlaugsson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gudlaugsson Ólafur</a>, <a href="/search?value1=Siri+Helene+Hauge&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hauge Siri Helene</a>, <a href="/search?value1=Outi+Lyytik%C3%A4inen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lyytikäinen Outi</a>, <a href="/search?value1=Gu%C3%B0r%C3%BAn+Sigmundsd%C3%B3ttir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sigmundsdóttir Guðrún</a>, <a href="/search?value1=Anders+Tegnell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tegnell Anders</a>, <a href="/search?value1=Mikko+Virtanen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Virtanen Mikko</a>, <a href="/search?value1=the+Nordic+influenza+comparison+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">the Nordic influenza comparison group</a></span>. Pandemic vaccination strategies and influenza severe outcomes during the influenza A(H1N1)pdm09 pandemic and the post-pandemic influenza season: the Nordic experience. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(16):pii=30208. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.16.30208" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.16.30208</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Apr 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Dec 2015 </span> </p>
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