1887
Rapid communication Open Access
Like 0

Abstract

We report miscarriage following dengue virus (DENV)-3 infection in a pregnant woman returning from Bali to Italy in April 2016. On her arrival, the woman had fever, rash, asthenia and headache. DENV RNA was detected in plasma and urine samples collected the following day. Six days after symptom onset, she had a miscarriage. DENV RNA was detected in fetal material, but in utero fetal infection cannot be demonstrated due to possible contamination by maternal blood.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.31.30308
2016-08-04
2024-10-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.31.30308
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/31/eurosurv-21-30308-1.html?itemId=/content/10.2807/1560-7917.ES.2016.21.31.30308&mimeType=html&fmt=ahah

References

  1. Timiryasova TM, Bonaparte MI, Luo P, Zedar R, Hu BT, Hildreth SW. Optimization and validation of a plaque reduction neutralization test for the detection of neutralizing antibodies to four serotypes of dengue virus used in support of dengue vaccine development. Am J Trop Med Hyg. 2013;88(5):962-70.  https://doi.org/10.4269/ajtmh.12-0461  PMID: 23458954 
  2. Scaramozzino N, Crance JM, Jouan A, DeBriel DA, Stoll F, Garin D. Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol. 2001;39(5):1922-7.  https://doi.org/10.1128/JCM.39.5.1922-1927.2001  PMID: 11326014 
  3. Huhtamo E, Hasu E, Uzcátegui NY, Erra E, Nikkari S, Kantele A, et al. Early diagnosis of dengue in travelers: comparison of a novel real-time RT-PCR, NS1 antigen detection and serology. J Clin Virol. 2010;47(1):49-53.  https://doi.org/10.1016/j.jcv.2009.11.001  PMID: 19963435 
  4. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14(8):1232-9.  https://doi.org/10.3201/eid1408.080287  PMID: 18680646 
  5. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016;374(10):951-8.  https://doi.org/10.1056/NEJMoa1600651  PMID: 26862926 
  6. Centers for Disease Control and Prevention (CDC). Intrauterine West Nile virus infection--New York, 2002. MMWR Morb Mortal Wkly Rep. 2002;51(50):1135-6. PMID: 12537289 
  7. O’Leary DR, Kuhn S, Kniss KL, Hinckley AF, Rasmussen SA, Pape WJ, et al. Birth outcomes following West Nile Virus infection of pregnant women in the United States: 2003-2004. Pediatrics. 2006;117(3):e537-45.  https://doi.org/10.1542/peds.2005-2024  PMID: 16510632 
  8. Fritel X, Rollot O, Gerardin P, Gauzere BA, Bideault J, Lagarde L, et al. Chikungunya virus infection during pregnancy, Reunion, France, 2006. Emerg Infect Dis. 2010;16(3):418-25.  https://doi.org/10.3201/eid1604.091403  PMID: 20202416 
  9. Chitra TV, Panicker S. Maternal and fetal outcome of dengue fever in pregnancy. J Vector Borne Dis. 2011;48(4):210-3. PMID: 22297282 
  10. Pouliot SH, Xiong X, Harville E, Paz-Soldan V, Tomashek KM, Breart G, et al. Maternal dengue and pregnancy outcomes: a systematic review. Obstet Gynecol Surv. 2010;65(2):107-18.  https://doi.org/10.1097/OGX.0b013e3181cb8fbc  PMID: 20100360 
  11. Tan PC, Rajasingam G, Devi S, Omar SZ. Dengue infection in pregnancy: prevalence, vertical transmission, and pregnancy outcome. Obstet Gynecol. 2008;111(5):1111-7.  https://doi.org/10.1097/AOG.0b013e31816a49fc  PMID: 18448743 
  12. Kariyawasam S, Senanayake H. Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka. J Infect Dev Ctries. 2010;4(11):767-75.  https://doi.org/10.3855/jidc.908  PMID: 21252457 
  13. Bharaj P, Chahar HS, Pandey A, Diddi K, Dar L, Guleria R, et al. Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India. Virol J. 2008;5(1):1.  https://doi.org/10.1186/1743-422X-5-1  PMID: 18182120 
  14. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181(1):2-9.  https://doi.org/10.1086/315215  PMID: 10608744 
  15. Basurko C, Carles G, Youssef M, Guindi WE. Maternal and fetal consequences of dengue fever during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2009;147(1):29-32.  https://doi.org/10.1016/j.ejogrb.2009.06.028  PMID: 19632027 
  16. Ismail NA, Kampan N, Mahdy ZA, Jamil MA, Razi ZR. Dengue in pregnancy. Southeast Asian J Trop Med Public Health. 2006;37(4):681-3. PMID: 17121293 
  17. Waduge R, Malavige GN, Pradeepan M, Wijeyaratne CN, Fernando S, Seneviratne SL. Dengue infections during pregnancy: a case series from Sri Lanka and review of the literature. J Clin Virol. 2006;37(1):27-33.  https://doi.org/10.1016/j.jcv.2006.06.002  PMID: 16843056 
  18. Magara M. Dengue fever in the fields of obstetrics and gynecology. Nippon Igaku Hoshasen Gakkai Zasshi. 1942;3306:1186-90.
  19. Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW. The role of infection in miscarriage. Hum Reprod Update. 2016;22(1):116-33.  https://doi.org/10.1093/humupd/dmv041  PMID: 26386469 
  20. Edwards MJ. Review: Hyperthermia and fever during pregnancy. Birth Defects Res A Clin Mol Teratol. 2006;76(7):507-16.  https://doi.org/10.1002/bdra.20277  PMID: 16933304 
  21. Iyngkaran N, Yadav M, Sinniah M. Augmented inflammatory cytokines in primary dengue infection progressing to shock. Singapore Med J. 1995;36(2):218-21. PMID: 7676273 
/content/10.2807/1560-7917.ES.2016.21.31.30308
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error