-
Brucellosis in a refugee who migrated from Syria to Germany and lessons learnt, 2016
- Roland Grunow1 , Daniela Jacob1 , Silke Klee1 , Dietmar Schlembach2 , Sabine Jackowski-Dohrmann3 , Vera Loenning-Baucke4 , Bettina Eberspächer5 , Sonja Swidsinski5
-
View Affiliations Hide AffiliationsAffiliations: 1 Robert Koch Institute, Berlin, Germany 2 Vivantes Klinikum Neukölln, Geburtsmedizin, Berlin, Germany 3 Vivantes Klinikum Neukölln, Kinder und Jugendmedizin, Berlin, Germany 4 Charité Hospital, Campus Charité Mitte, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany 5 Labor Berlin, Berlin, GermanyRoland GrunowGrunowR rki.de
-
View Citation Hide Citation
Citation style for this article: Grunow Roland, Jacob Daniela, Klee Silke, Schlembach Dietmar, Jackowski-Dohrmann Sabine, Loenning-Baucke Vera, Eberspächer Bettina, Swidsinski Sonja. Brucellosis in a refugee who migrated from Syria to Germany and lessons learnt, 2016. Euro Surveill. 2016;21(31):pii=30311. https://doi.org/10.2807/1560-7917.ES.2016.21.31.30311 Received: 21 Jul 2016; Accepted: 03 Aug 2016
Abstract
A teenage woman migrating from Syria arrived in May 2015 in Germany. She gave birth to a healthy child in early 2016, but became febrile shortly after delivery. Blood cultures revealed Brucella melitensis. In retrospect, she reported contact with sheep in Syria and recurrent pain in the hip joints over about five months before diagnosis of brucellosis. We discuss consequences for adequate treatment of mother and child as well as for clinical and laboratory management.
Article metrics loading...
Full text loading...
References
-
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006;6(2):91-9. https://doi.org/10.1016/S1473-3099(06)70382-6 PMID: 16439329
-
Garofolo G, Fasanella A, Di Giannatale E, Platone I, Sacchini L, Persiani T, et al. Cases of human brucellosis in Sweden linked to Middle East and Africa. BMC Res Notes. 2016;9(1):277. https://doi.org/10.1186/s13104-016-2074-7 PMID: 27188619
-
Norman FF, Monge-Maillo B, Chamorro-Tojeiro S, Pérez-Molina JA, López-Vélez R. Imported brucellosis: A case series and literature review. Travel Med Infect Dis. 2016;14(3):182-99. https://doi.org/10.1016/j.tmaid.2016.05.005 PMID: 27185403
-
Garcell HG, Garcia EG, Pueyo PV, Martín IR, Arias AV, Alfonso Serrano RN. Outbreaks of brucellosis related to the consumption of unpasteurized camel milk. J Infect Public Health. 2016;9(4):523-7. https://doi.org/10.1016/j.jiph.2015.12.006 PMID: 26796768
-
Al Dahouk S, Neubauer H, Hensel A, Schöneberg I, Nöckler K, Alpers K, et al. Changing epidemiology of human brucellosis, Germany, 1962-2005. Emerg Infect Dis. 2007;13(12):1895-900. https://doi.org/10.3201/eid1312.070527 PMID: 18258041
-
Bosilkovski M, Krteva L, Caparoska S, Labacevski N, Petrovski M. Childhood brucellosis: Review of 317 cases. Asian Pac J Trop Med. 2015;8(12):1027-32. https://doi.org/10.1016/j.apjtm.2015.11.009 PMID: 26706674
-
Cacace ML, Claros EA, Erazu KA, Escobar GI, Lucero NE. Congenital brucellosis in an infant. Vector Borne Zoonotic Dis. 2013;13(7):513-5. https://doi.org/10.1089/vbz.2012.1165 PMID: 23590322
-
Kim JY, Kang SI, Lee JJ, Lee K, Sung SR, Erdenebaataar J, et al. Differential diagnosis of Brucella abortus by real-time PCR based on a single-nucleotide polymorphisms. J Vet Med Sci. 2016;78(4):557-62. https://doi.org/10.1292/jvms.15-0541 PMID: 26666176
-
Piranfar V, Sharif M, Hashemi M, Vahdati AR, Mirnejad R. Detection and discrimination of two Brucella species by multiplex real-time PCR and high-resolution melt analysis curve from human blood and comparison of results using RFLP. Iran J Basic Med Sci. 2015;18(9):909-14. PMID: 26523223
-
Hänsel C, Mertens K, Elschner MC, Melzer F. Novel real-time PCR detection assay for Brucella suis. Vet Rec Open. 2015;2(1):e000084. https://doi.org/10.1136/vetreco-2014-000084 PMID: 26392898
-
Lasch P, Wahab T, Weil S, Pályi B, Tomaso H, Zange S, et al. Identification of highly pathogenic microorganisms by matrix-assisted laser desorption Ionization-time of flight mass spectrometry: Results of an interlaboratory ring trial. J Clin Microbiol. 2015;53(8):2632-40. https://doi.org/10.1128/JCM.00813-15 PMID: 26063856
-
Karger A, Melzer F, Timke M, Bettin B, Kostrzewa M, Nöckler K, et al. Interlaboratory comparison of intact-cell matrix-assisted laser desorption ionization-time of flight mass spectrometry results for identification and differentiation of Brucella spp. J Clin Microbiol. 2013;51(9):3123-6. https://doi.org/10.1128/JCM.01720-13 PMID: 23850950
-
Mesureur J, Ranaldi S, Monnin V, Girard V, Arend S, Welker M, et al. A Simple and safe protocol for preparing Brucella samples for matrix-assisted laser desorption Ionization-time of flight mass spectrometry analysis. J Clin Microbiol. 2016;54(2):449-52. https://doi.org/10.1128/JCM.02730-15 PMID: 26582837
-
Scholz HC, Vergnaud G. Molecular characterisation of Brucella species. Rev Sci Tech. 2013;32(1):149-62. https://doi.org/10.20506/rst.32.1.2189 PMID: 23837373
-
Garofolo G, Di Giannatale E, De Massis F, Zilli K, Ancora M, Cammà C, et al. Investigating genetic diversity of Brucella abortus and Brucella melitensis in Italy with MLVA-16. Infect Genet Evol. 2013;19:59-70. https://doi.org/10.1016/j.meegid.2013.06.021 PMID: 23831636
-
Al Dahouk S, Sprague LD, Neubauer H. New developments in the diagnostic procedures for zoonotic brucellosis in humans. Rev Sci Tech. 2013;32(1):177-88. https://doi.org/10.20506/rst.32.1.2204 PMID: 23837375
-
Solís García Del Pozo J, Lorente Ortuño S, Navarro E, Solera J. Detection of IgM antibrucella antibody in the absence of IgGs: a challenge for the clinical interpretation of brucella serology. PLoS Negl Trop Dis. 2014;8(12):e3390. https://doi.org/10.1371/journal.pntd.0003390 PMID: 25474572
-
Lowe CF, Showler AJ, Perera S, McIntyre S, Qureshi R, Patel SN, et al. Hospital-associated transmission of Brucella melitensis outside the laboratory. Emerg Infect Dis. 2015;21(1):150-2. https://doi.org/10.3201/eid2101.141247 PMID: 25531198
-
Yagupsky P, Baron EJ. Laboratory exposures to brucellae and implications for bioterrorism. Emerg Infect Dis. 2005;11(8):1180-5. https://doi.org/10.3201/eid1108.041197 PMID: 16102304
-
Traxler RM, Lehman MW, Bosserman EA, Guerra MA, Smith TL. A literature review of laboratory-acquired brucellosis. J Clin Microbiol. 2013;51(9):3055-62. https://doi.org/10.1128/JCM.00135-13 PMID: 23824774
-
Singh K. Laboratory-acquired infections. Clin Infect Dis. 2009;49(1):142-7. https://doi.org/10.1086/599104 PMID: 19480580
-
Regulations DG. (DGR). International Air Transport Association (IATA); 2016. Available from: http://www.iata.org/publications/dgr/Pages/manuals.aspx
-
European Agreement concerning the International Carriage of Dangerous Goods by Road. ADR applicable as from 1 January 2015. Geneva: United Nations Economic Commission for Europe (UNECE); 2015. Available from: http://www.unece.org/trans/danger/publi/adr/adr2015/15contentse.html
-
Rhodes HM, Williams DN, Hansen GT. Invasive human brucellosis infection in travelers to and immigrants from the Horn of Africa related to the consumption of raw camel milk. Travel Med Infect Dis. 2016;14(3):255-60. https://doi.org/10.1016/j.tmaid.2016.03.013 PMID: 27038818
Data & Media loading...