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Abstract

The 2014/15 influenza season in Japan was characterised by predominant influenza A(H3N2) activity; 99% of influenza A viruses detected were A(H3N2). Subclade 3C.2a viruses were the major epidemic A(H3N2) viruses, and were genetically distinct from A/New York/39/2012(H3N2) of 2014/15 vaccine strain in Japan, which was classified as clade 3C.1. We assessed vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children aged 6 months to 15 years by test-negative case–control design based on influenza rapid diagnostic test. Between November 2014 and March 2015, a total of 3,752 children were enrolled: 1,633 tested positive for influenza A and 42 for influenza B, and 2,077 tested negative. Adjusted VE was 38% (95% confidence intervals (CI): 28 to 46) against influenza virus infection overall, 37% (95% CI: 27 to 45) against influenza A, and 47% (95% CI: -2 to 73) against influenza B. However, IIV was not statistically significantly effective against influenza A in infants aged 6 to 11 months or adolescents aged 13 to 15 years. VE in preventing hospitalisation for influenza A infection was 55% (95% CI: 42 to 64). Trivalent IIV that included A/New York/39/2012(H3N2) was effective against drifted influenza A(H3N2) virus, although vaccine mismatch resulted in low VE.

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/content/10.2807/1560-7917.ES.2016.21.42.30377
2016-10-20
2024-09-07
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.42.30377
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Trivalent inactivated influenza vaccine effective against influenza A(H3N2) variant viruses in children during the 2014/15 season, Japan
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Norio+Sugaya&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sugaya Norio</a>, <a href="/search?value1=Masayoshi+Shinjoh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shinjoh Masayoshi</a>, <a href="/search?value1=Chiharu+Kawakami&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kawakami Chiharu</a>, <a href="/search?value1=Yoshio+Yamaguchi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yamaguchi Yoshio</a>, <a href="/search?value1=Makoto+Yoshida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yoshida Makoto</a>, <a href="/search?value1=Hiroaki+Baba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baba Hiroaki</a>, <a href="/search?value1=Mayumi+Ishikawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ishikawa Mayumi</a>, <a href="/search?value1=Mio+Kono&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kono Mio</a>, <a href="/search?value1=Shinichiro+Sekiguchi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sekiguchi Shinichiro</a>, <a href="/search?value1=Takahisa+Kimiya&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kimiya Takahisa</a>, <a href="/search?value1=Keiko+Mitamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mitamura Keiko</a>, <a href="/search?value1=Motoko+Fujino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujino Motoko</a>, <a href="/search?value1=Osamu+Komiyama&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Komiyama Osamu</a>, <a href="/search?value1=Naoko+Yoshida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yoshida Naoko</a>, <a href="/search?value1=Kenichiro+Tsunematsu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tsunematsu Kenichiro</a>, <a href="/search?value1=Atsushi+Narabayashi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Narabayashi Atsushi</a>, <a href="/search?value1=Yuji+Nakata&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nakata Yuji</a>, <a href="/search?value1=Akihiro+Sato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sato Akihiro</a>, <a href="/search?value1=Nobuhiko+Taguchi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Taguchi Nobuhiko</a>, <a href="/search?value1=Hisayo+Fujita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujita Hisayo</a>, <a href="/search?value1=Machiko+Toki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Toki Machiko</a>, <a href="/search?value1=Michiko+Myokai&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Myokai Michiko</a>, <a href="/search?value1=Ichiro+Ookawara&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ookawara Ichiro</a>, <a href="/search?value1=Takao+Takahashi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takahashi Takao</a></span>. Trivalent inactivated influenza vaccine effective against influenza A(H3N2) variant viruses in children during the 2014/15 season, Japan. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(42):pii=30377. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.42.30377" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.42.30377</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 29 Dec 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Jun 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.42.30377
/content/10.2807/1560-7917.ES.2016.21.42.30377
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