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Abstract

Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to March 2014 for studies assessing the protective effect of influenza vaccination vs no vaccination on influenza virus infections in contacts. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. Of 43,082 screened articles, nine randomised controlled trials (RCTs) and four observational studies were eligible. Among the RCTs, no statistically significant herd effect on the occurrence of influenza in contacts could be found (OR: 0.62; 95% CI: 0.34–1.12). The one RCT conducted in a community setting, however, showed a significant effect (OR: 0.39; 95% CI: 0.26–0.57), as did the observational studies (OR: 0.57; 95% CI: 0.43–0.77). We found only a few studies that quantified the herd effect of vaccination, all studies except one were conducted in children, and the overall evidence was graded as low. The evidence is too limited to conclude in what setting(s) a herd effect may or may not be achieved.

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2016-10-20
2024-09-11
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.42.30378
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References

  1. Dawood FS, Iuliano AD, Reed C, Meltzer MI, Shay DK, Cheng PY, et al. Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study. Lancet Infect Dis. 2012;12(9):687-95.  https://doi.org/10.1016/S1473-3099(12)70121-4  PMID: 22738893 
  2. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095-128.  https://doi.org/10.1016/S0140-6736(12)61728-0  PMID: 23245604 
  3. Nair H, Brooks WA, Katz M, Roca A, Berkley JA, Madhi SA, et al. Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet. 2011;378(9807):1917-30.  https://doi.org/10.1016/S0140-6736(11)61051-9  PMID: 22078723 
  4. Centers for Disease Control and Prevention (CDC). People at High Risk of Developing Flu-Related Complications. Atlanta, GA: CDC. [Accessed 21 Oct 2015]. Available from: http://www.cdc.gov/flu/index.htm
  5. Fiore AE, Uyeki TM, Broder K, Finelli L, Euler GL, Singleton JA, et al. Centers for Disease Control and Prevention (CDC). Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Recomm Rep. 2010;59(RR-8):1-62. PMID: 20689501 
  6. Strategic Advisory Group of Experts on Immunization - report of the extraordinary meeting on the influenza A (H1N1) 2009 pandemic, 7 July 2009. Wkly Epidemiol Rec. 2009;84(30):301-4. PMID: 19630186 
  7. World Health Organization (WHO). SAGE meeting of April 2012. Geneva: WHO. [Accessed 21 Oct 2015]. Available from: http://www.who.int/influenza/vaccines/SAGE_information/en/index.html
  8. Agarwal S, Busse PJ. Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol. 2010;104(3):183-90, quiz 190-2, 210.  https://doi.org/10.1016/j.anai.2009.11.009  PMID: 20377107 
  9. Desai A, Grolleau-Julius A, Yung R. Leukocyte function in the aging immune system. J Leukoc Biol. 2010;87(6):1001-9.  https://doi.org/10.1189/jlb.0809542  PMID: 20200405 
  10. Reichert TA, Sugaya N, Fedson DS, Glezen WP, Simonsen L, Tashiro M. The Japanese experience with vaccinating schoolchildren against influenza. N Engl J Med. 2001;344(12):889-96.  https://doi.org/10.1056/NEJM200103223441204  PMID: 11259722 
  11. Basta NE, Chao DL, Halloran ME, Matrajt L, Longini IM Jr. Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States. Am J Epidemiol. 2009;170(6):679-86.  https://doi.org/10.1093/aje/kwp237  PMID: 19679750 
  12. Loeb M, Russell ML, Moss L, Fonseca K, Fox J, Earn DJ, et al. Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial. JAMA. 2010;303(10):943-50.  https://doi.org/10.1001/jama.2010.250  PMID: 20215608 
  13. Hurwitz ES, Haber M, Chang A, Shope T, Teo S, Ginsberg M, et al. Effectiveness of influenza vaccination of day care children in reducing influenza-related morbidity among household contacts. JAMA. 2000;284(13):1677-82.  https://doi.org/10.1001/jama.284.13.1677  PMID: 11015798 
  14. King JC Jr, Stoddard JJ, Gaglani MJ, Moore KA, Magder L, McClure E, et al. Effectiveness of school-based influenza vaccination. N Engl J Med. 2006;355(24):2523-32.  https://doi.org/10.1056/NEJMoa055414  PMID: 17167135 
  15. Centre for Reviews and Dissemination. University of York. PROSPERO. International prospective register of systematic reviews. York: Centre for Reviews and Dissemination, University of York. [Accessed 5 Oct 2016]. Available from: http://www.crd.york.ac.uk/PROSPERO/
  16. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1-34.  https://doi.org/10.1016/j.jclinepi.2009.06.006  PMID: 19631507 
  17. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). London: The Cochrane Collaboration; 2011. Available from: http://handbook.cochrane.org
  18. Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa, ON: Ottawa Hospital Research Institute. [Accessed 21 Oct 2015]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
  19. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328(7454):1490.  https://doi.org/10.1136/bmj.328.7454.1490  PMID: 15205295 
  20. Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 2011;343(jul22 1):d4002.  https://doi.org/10.1136/bmj.d4002  PMID: 21784880 
  21. Cochrane Informatics and Knowledge Management Department. RevMan 5 download and installation. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration. [Accessed 5 Oct 2016]. Available from: http://tech.cochrane.org/revman/download
  22. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.  https://doi.org/10.1136/bmj.327.7414.557  PMID: 12958120 
  23. Rudenko LG, Slepushkin AN, Monto AS, Kendal AP, Grigorieva EP, Burtseva EP, et al. Efficacy of live attenuated and inactivated influenza vaccines in schoolchildren and their unvaccinated contacts in Novgorod, Russia. J Infect Dis. 1993;168(4):881-7.  https://doi.org/10.1093/infdis/168.4.881  PMID: 8376833 
  24. Principi N, Esposito S, Marchisio P, Gasparini R, Crovari P. Socioeconomic impact of influenza on healthy children and their families. Pediatr Infect Dis J. 2003;22(10) Suppl;S207-10.  https://doi.org/10.1097/01.inf.0000092188.48726.e4  PMID: 14551476 
  25. Ghendon YZ, Kaira AN, Elshina GA. The effect of mass influenza immunization in children on the morbidity of the unvaccinated elderly. Epidemiol Infect. 2006;134(1):71-8.  https://doi.org/10.1017/S0950268805005650  PMID: 16316494 
  26. Piedra PA, Gaglani MJ, Kozinetz CA, Herschler G, Riggs M, Griffith M, et al. Herd immunity in adults against influenza-related illnesses with use of the trivalent-live attenuated influenza vaccine (CAIV-T) in children. Vaccine. 2005;23(13):1540-8.  https://doi.org/10.1016/j.vaccine.2004.09.025  PMID: 15694506 
  27. Kjos SA, Irving SA, Meece JK, Belongia EA. Elementary school-based influenza vaccination: evaluating impact on respiratory illness absenteeism and laboratory-confirmed influenza. PLoS One. 2013;8(8):e72243.  https://doi.org/10.1371/journal.pone.0072243  PMID: 23991071 
  28. Monto AS, Davenport FM, Napier JA, Francis T Jr. Modification of an outbreak of influenza in Tecumseh, Michigan by vaccination of schoolchildren. J Infect Dis. 1970;122(1):16-25.  https://doi.org/10.1093/infdis/122.1-2.16  PMID: 5433709 
  29. Gruber WC, Taber LH, Glezen WP, Clover RD, Abell TD, Demmler RW, et al. Live attenuated and inactivated influenza vaccine in school-age children. Am J Dis Child. 1990;144(5):595-600. PMID: 2330929 
  30. Cowling BJ, Ng S, Ma ESK, Fang VJ, So HC, Wai W, et al. Protective efficacy against pandemic influenza of seasonal influenza vaccination in children in Hong Kong: a randomized controlled trial. Clin Infect Dis. 2012;55(5):695-702.  https://doi.org/10.1093/cid/cis518  PMID: 22670050 
  31. Hui LS, Rashwan H, bin Jaafar MH, Hussaini HM, Isahak DI. Effectiveness of influenza vaccine in preventing influenza-like illness among faculty of dentistry staff and students in Universiti Kebangsaan Malaysia. Healthc Infect. 2008;13(1):4-9 . https://doi.org/10.1071/HI08003 
  32. Pannaraj PS, Wang HL, Rivas H, Wiryawan H, Smit M, Green N, et al. School-located influenza vaccination decreases laboratory-confirmed influenza and improves school attendance. Clin Infect Dis. 2014;59(3):325-32.  https://doi.org/10.1093/cid/ciu340  PMID: 24829215 
  33. Clover RD, Crawford S, Glezen WP, Taber LH, Matson CC, Couch RB. Comparison of heterotypic protection against influenza A/Taiwan/86 (H1N1) by attenuated and inactivated vaccines to A/Chile/83-like viruses. J Infect Dis. 1991;163(2):300-4.  https://doi.org/10.1093/infdis/163.2.300  PMID: 1988512 
  34. Esposito S, Marchisio P, Cavagna R, Gironi S, Bosis S, Lambertini L, et al. Effectiveness of influenza vaccination of children with recurrent respiratory tract infections in reducing respiratory-related morbidity within the households. Vaccine. 2003;21(23):3162-8.  https://doi.org/10.1016/S0264-410X(03)00253-6  PMID: 12804844 
Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Dominik+Mertz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mertz Dominik</a>, <a href="/search?value1=Shaza+A.+Fadel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fadel Shaza A.</a>, <a href="/search?value1=Po-Po+Lam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lam Po-Po</a>, <a href="/search?value1=Dat+Tran&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tran Dat</a>, <a href="/search?value1=Jocelyn+A+Srigley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Srigley Jocelyn A</a>, <a href="/search?value1=Sandra+A+Asner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Asner Sandra A</a>, <a href="/search?value1=Michelle+Science&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Science Michelle</a>, <a href="/search?value1=Stefan+P+Kuster&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuster Stefan P</a>, <a href="/search?value1=Johannes+Nemeth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nemeth Johannes</a>, <a href="/search?value1=Jennie+Johnstone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johnstone Jennie</a>, <a href="/search?value1=Justin+R+Ortiz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ortiz Justin R</a>, <a href="/search?value1=Mark+Loeb&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Loeb Mark</a></span>. Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(42):pii=30378. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.42.30378" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.42.30378</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Oct 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 23 Apr 2016 </span> </p>
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