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Surveillance and outbreak report Open Access
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Abstract

In the United Kingdom, pertussis guidance recommends prophylaxis for household contacts within 21 days of case symptom onset if the household includes a vulnerable contact. The aim of our study was to identify characteristics associated with cases reported late for public health action. We reviewed the epidemiology of cases reported in London and South East England for the period 2010 to 2015. We characterised risk factors associated with late reporting of cases and described public health actions taken on timely reported cases. From 2010 to 2015, 9,163 cases of pertussis were reported to health protection teams. Only 11% of cases were reported within 21 days of onset, limiting opportunities for secondary prevention. Timely reporting was associated with younger age groups, pregnancy, being a healthcare worker and being reported by schools or hospital clinicians. Late reporting was associated with older age groups and general practitioner or laboratory reporting. Delays, such as those due to insidious onset and late presentation to healthcare, may be unavoidable; however, delay in reporting once a patient presents can be reduced since cases can be reported before laboratory confirmation. Thus we recommend working with clinicians and laboratories to determine causes and improve early reporting to public health.

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/content/10.2807/1560-7917.ES.2017.22.29.30577
2017-07-20
2024-12-08
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.29.30577
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References

  1. Public Health England (PHE). Pertussis: clinical and public health management. Guidance. London: PHE; 2013. Available from: https://www.gov.uk/guidance/pertussis-clinical-and-public-health-management
  2. Screening and Immunisations Team, Health and Social Care Information Centre. NHS immunisation statistics England, 2014-15. Leeds: Health and Social Care Information Centre (HSCIC); 2015.
  3. Melvin JA, Scheller EV, Miller JF, Cotter PA. Bordetella pertussis pathogenesis: current and future challenges. Nat Rev Microbiol. 2014;12(4):274-88. . Available from: http://www.ncbi.nlm.nih.gov/pubmed/24608338 https://doi.org/10.1038/nrmicro3235  PMID: 24608338 
  4. Teepe J, Broekhuizen BD, Ieven M, Loens K, Huygen K, Kretzschmar M, et al. Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care. Br J Gen Pract. 2015;65(639):e662-7.  https://doi.org/10.3399/bjgp15X686917  PMID: 26412843 
  5. Public Health England (PHE). Guidelines for the public health management of pertussis in England (December 2016). London: PHE; 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/541694/Guidelines_for_the_Public_Health_Management_of_Pertussis_in_England.pdf
  6. Solano R, Rius C, Simón P, Manzanares-Laya S, Ros M, Toledo D, et al. Evaluation of reported cases of pertussis: epidemiological study in a large city in Spain. J Med Microbiol. 2014;63(Pt 12):1688-95.  https://doi.org/10.1099/jmm.0.079756-0  PMID: 25261062 
  7. Carlsson RM, von Segebaden K, Bergstrom J, Kling AM, Nilsson L. Surveillance of infant pertussis in Sweden 1998-2012; severity of disease in relation to the national vaccination programme. Euro Surveill. 2015;20(6):21032.  https://doi.org/10.2807/1560-7917.ES2015.20.6.21032  PMID: 25695476 
  8. von König CH, Halperin S, Riffelmann M, Guiso N. Pertussis of adults and infants. Lancet Infect Dis. 2002;2(12):744-50.  https://doi.org/10.1016/S1473-3099(02)00452-8  PMID: 12467690 
  9. Gilberg S, Njamkepo E, Du Châtelet IP, Partouche H, Gueirard P, Ghasarossian C, et al. Evidence of Bordetella pertussis infection in adults presenting with persistent cough in a french area with very high whole-cell vaccine coverage. J Infect Dis. 2002;186(3):415-8.  https://doi.org/10.1086/341511  PMID: 12134239 
  10. Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ. Pertussis: microbiology, disease, treatment, and prevention. Clin Microbiol Rev. 2016;29(3):449-86.  https://doi.org/10.1128/CMR.00083-15  PMID: 27029594 
  11. Kayina V, Kyobe S, Katabazi FA, Kigozi E, Okee M, Odongkara B, et al. Pertussis prevalence and its determinants among children with persistent cough in urban Uganda. PLoS One. 2015;10(4):e0123240.  https://doi.org/10.1371/journal.pone.0123240  PMID: 25874411 
  12. Wendelboe AM, Njamkepo E, Bourillon A, Floret DD, Gaudelus J, Gerber M, et al. Transmission of Bordetella pertussis to young infants. Pediatr Infect Dis J. 2007;26(4):293-9.  https://doi.org/10.1097/01.inf.0000258699.64164.6d  PMID: 17414390 
  13. English indices of deprivation 2015. Newport; Office of National Statistics; 2015. Available from: https://www.gov.uk/government/statistics/english-indices-of-deprivation-2015
  14. Smith T, Noble M, Noble S, Wright G, McLennan D, Plunkett E. The English indices of deprivation 2015 technical report. London: Department of Communities and Local Government; 2015. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/464485/English_Indices_of_Deprivation_2015_-_Technical-Report.pdf
  15. Mid-2014 population estimates for clinical commissioning groups (CCGs) in England by single year of age and sex. Newport; Office of National Statistics; 2015. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates/datasets/clinicalcommissioninggroupmidyearpopulationestimates
  16. Frumkin K. Pertussis and persistent cough: practical, clinical and epidemiologic issues. J Emerg Med. 2013;44(4):889-95.  https://doi.org/10.1016/j.jemermed.2012.09.037  PMID: 23287746 
  17. Haslam N, Hoang U, Goldacre MJ. Trends in hospital admission rates for whooping cough in England across five decades: database studies. J R Soc Med. 2014;107(4):157-62.  https://doi.org/10.1177/0141076813519439  PMID: 24526463 
  18. Pertussis. In: Immunisation against infectious diseases (The Green Book). Salisbury D, Ramsay M, eds. London: PHE; 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/514363/Pertussis_Green_Book_Chapter_24_Ap2016.pdf
  19. Campbell H, Amirthalingam G, Andrews N, Fry NK, George RC, Harrison TG, et al. Accelerating control of pertussis in England and Wales. Emerg Infect Dis. 2012;18(1):38-47.  https://doi.org/10.3201/eid1801.110784  PMID: 22260989 
  20. The Health Protection (Notification) Regulations 2010. Statutory Instruments. 2010, No. 659. London: Department of Health; 2010. Available from: http://www.legislation.gov.uk/uksi/2010/659/pdfs/uksi_20100659_en.pdf
  21. Dodhia H, Miller E. Review of the evidence for the use of erythromycin in the management of persons exposed to pertussis. Epidemiol Infect. 1998;120(2):143-9.  https://doi.org/10.1017/S0950268897008571  PMID: 9593483 
  22. Chen RT, Orenstein WA. Epidemiologic methods in immunization programs. Epidemiol Rev. 1996;18(2):99-117.  https://doi.org/10.1093/oxfordjournals.epirev.a017931  PMID: 9021306 
  23. Eberhardt CS, Blanchard-Rohner G, Lemaître B, Boukrid M, Combescure C, Othenin-Girard V, et al. Maternal immunization earlier in pregnancy maximizes antibody transfer and expected infant seropositivity against pertussis. Clin Infect Dis. 2016;62(7):829-36.  https://doi.org/10.1093/cid/ciw027  PMID: 26797213 
  24. Joint Committee on Vaccination and Immunisation (JCVI). Minutes of the meeting on 3 February 2016 Oxford Martin School, Oxford. Available from: https://app.box.com/s/iddfb4ppwkmtjusir2tc/file/66698939189
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