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Abstract

The United Kingdom is introducing a universal annual influenza vaccination programme for children. Live attenuated influenza vaccine (LAIV) effectiveness (VE) against laboratory-confirmed influenza hospitalisation in 2 to 6 year-olds in England was measured in 2015/16 using the screening method. VE adjusted for age, geography and month was 54.5% (95% confidence interval (CI): 31.5% to 68.4%) for all influenza types combined; 48.3% (95% CI: 16.9% to 67.8%) for A(H1N1)pdm09 and 70.6% (95% CI: 33.2% to 87.1%) for B. The findings support on-going programme roll-out.

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/content/10.2807/1560-7917.ES.2017.22.4.30450
2017-01-26
2019-12-11
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.4.30450
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References

  1. Hakin B, Cosford P, Harvey F. The flu immunisation programme 2013/14 – extension to children. London: Department of Health; 26 Jul 2013. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/225360/Children_s_flu_letter_2013.pdf
  2. Public Health England (PHE). Flu plan. Winter 2015/16. London: PHE; May 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/526143/Flu_Plan_Winter_2015_to_2016superseded.pdf
  3. Pebody R, Warburton F, Andrews N, Ellis J, von Wissmann B, Robertson C, et al. Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 end of season results. Euro Surveill. 2015;20(36):30013.  https://doi.org/10.2807/1560-7917.ES.2015.20.36.30013  PMID: 26535911 
  4. Pebody R, Warburton F, Ellis J, Andrews N, Potts A, Cottrell S, et al. Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results. Euro Surveill. 2016;21(38):30348.  https://doi.org/10.2807/1560-7917.ES.2016.21.38.30348  PMID: 27684603 
  5. Bolotin S, Pebody R, White PJ, McMenamin J, Perera L, Nguyen-Van-Tam JS, et al. UK Severe Influenza Surveillance System (USISS) Steering Group. A new sentinel surveillance system for severe influenza in England shows a shift in age distribution of hospitalised cases in the post-pandemic period. PLoS One. 2012;7(1):e30279.  https://doi.org/10.1371/journal.pone.0030279  PMID: 22291929 
  6. Farrington CP. Estimation of vaccine effectiveness using the screening method. Int J Epidemiol. 1993;22(4):742-6.  https://doi.org/10.1093/ije/22.4.742  PMID: 8225751 
  7. Thomas HL, Andrews N, Green HK, Boddington NL, Zhao H, Reynolds A, et al. Estimating vaccine effectiveness against severe influenza in England and Scotland 2011/2012: applying the screening method to data from intensive care surveillance systems. Epidemiol Infect. 2014;142(1):126-33. PMID: 23591102 
  8. Public Health England (PHE). Influenza immunisation programme for England, GP patient groups, Season 2015 to 2016. London: PHE; May 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/544552/Seasonal_flu_GP_patient_groups_annual_report_2015_2016.pdf
  9. Public Health England (PHE). National Childhood Influenza Vaccination Programme 2015 to 2016, Seasonal influenza vaccine uptake for children of primary school age. London: PHE; May 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/544542/Childhood_Influenza_Vaccination_Programme_Report_2015_2016.pdf
  10. Health Protection Scotland (HPS). Flu vaccine effectiveness in Scottish primary school age children from the 2015/16 season. Glasgow: HPS. [Accessed 25 Jan 2017]. Available from: http://www.hps.scot.nhs.uk/resourcedocument.aspx?id=5529
  11. Nohynek H, Baum U, Syrjänen R, Ikonen N, Sundman J, Jokinen J. Effectiveness of the live attenuated and the inactivated influenza vaccine in two-year-olds - a nationwide cohort study Finland, influenza season 2015/16. Euro Surveill. 2016;21(38):30346.  https://doi.org/10.2807/1560-7917.ES.2016.21.38.30346  PMID: 27684447 
  12. Grohskopf LA, Sokolow LZ, Broder KR, Olsen SJ, Karron RA, Jernigan DB, et al. Prevention and Control of Seasonal Influenza with Vaccines. MMWR Recomm Rep. 2016;65(5):1-54.  https://doi.org/10.15585/mmwr.rr6505a1  PMID: 27560619 
  13. Rondy M, Castilla J, Launay O, Costanzo S, Ezpeleta C, Galtier F, et al. Moderate influenza vaccine effectiveness against hospitalisation with A(H3N2) and A(H1N1) influenza in 2013-14: Results from the InNHOVE network. Hum Vaccin Immunother. 2016;12(5):1217-24.  https://doi.org/10.1080/21645515.2015.1126013  PMID: 27065000 
  14. Penttinen PM, Friede MH. Decreased effectiveness of the influenza A(H1N1)pdm09 strain in live attenuated influenza vaccines: an observational bias or a technical challenge? Euro Surveill. 2016;21(38):30350.  https://doi.org/10.2807/1560-7917.ES.2016.21.38.30350  PMID: 27684999 
  15. Ambrose CS, Bright H, Mallory R. Letter to the editor: Potential causes of the decreased effectiveness of the influenza A(H1N1)pdm09 strain in live attenuated influenza vaccines. Euro Surveill. 2016;21(45):30394.  https://doi.org/10.2807/1560-7917.ES.2016.21.45.30394  PMID: 27918259 
  16. Public Health England (PHE). Surveillance of influenza and other respiratory viruses in the United Kingdom: Winter 2015 to 2016. London: PHE; May 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/526405/Flu_Annual_Report_2015_2016.pdf
  17. Joint Committee on Vaccination and Immunisation (JCVI). JCVI minutes of the meeting, 23 August 2016. JCVI. [Accessed 25 Jan 2017]. Available from: https://app.box.com/s/iddfb4ppwkmtjusir2tc/1/2199012147/98304591342/1
Live attenuated influenza vaccine effectiveness against hospitalisation due to laboratory-confirmed influenza in children two to six years of age in England in the 2015/16 season
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Richard+Pebody&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pebody Richard</a>, <a href="/search?value1=Bersabeh+Sile&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sile Bersabeh</a>, <a href="/search?value1=Fiona+Warburton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Warburton Fiona</a>, <a href="/search?value1=Mary+Sinnathamby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sinnathamby Mary</a>, <a href="/search?value1=Camille+Tsang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tsang Camille</a>, <a href="/search?value1=Hongxin+Zhao&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zhao Hongxin</a>, <a href="/search?value1=Joanna+Ellis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellis Joanna</a>, <a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a></span>. Live attenuated influenza vaccine effectiveness against hospitalisation due to laboratory-confirmed influenza in children two to six years of age in England in the 2015/16 season. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(4):pii=30450. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.4.30450" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.4.30450</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 09 Dec 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Jan 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.4.30450
/content/10.2807/1560-7917.ES.2017.22.4.30450
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