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Surveillance and outbreak report Open Access
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Abstract

In the summer of 2016, Belgium, France, Germany and the Netherlands reported widespread Usutu virus (USUV) activity based on live and dead bird surveillance. The causative USUV strains represented four lineages, of which two putative novel lineages were most likely recently introduced into Germany and spread to other western European countries. The spatial extent of the outbreak area corresponded with R values > 1. The occurrence of the outbreak, the largest USUV epizootic registered so far in Europe, allowed us to gain insight in how a recently introduced arbovirus with potential public health implications can spread and become a resident pathogen in a naïve environment. Understanding the ecological and epidemiological factors that drive the emergence or re-emergence of USUV is critical to develop and implement timely surveillance strategies for adequate preventive and control measures. Public health authorities, blood transfusion services and clinicians in countries where USUV was detected should be aware of the risk of possible USUV infection in humans, including in patients with unexplained encephalitis or other neurological impairments, especially during late summer when mosquito densities peak.

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/content/10.2807/1560-7917.ES.2017.22.4.30452
2017-01-26
2024-11-06
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.4.30452
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References

  1. McIntosh BM. Usutu (SAAr 1776), nouvel arbovirus du groupe B. Int Cat Arboviruses.1985;3:1059-60.
  2. Weissenböck H, Bakonyi T, Rossi G, Mani P, Nowotny N. Usutu virus, Italy, 1996. Emerg Infect Dis. 2013;19(2):274-7.  https://doi.org/10.3201/eid1902.121191  PMID: 23347844 
  3. Rijks JM, Kik ML, Slaterus R, Foppen R, Stroo A, IJzer J, et al. Widespread Usutu virus outbreak in birds in the Netherlands, 2016. Euro Surveill. 2016;21(45):30391.  https://doi.org/10.2807/1560-7917.ES.2016.21.45.30391  PMID: 27918257 
  4. Nikolay B. A review of West Nile and Usutu virus co-circulation in Europe: how much do transmission cycles overlap? Trans R Soc Trop Med Hyg. 2015;109(10):609-18.  https://doi.org/10.1093/trstmh/trv066  PMID: 26286946 
  5. Engel D, Jöst H, Wink M, Börstler J, Bosch S, Garigliany MM, et al. Reconstruction of the Evolutionary History and Dispersal of Usutu Virus, a Neglected Emerging Arbovirus in Europe and Africa. MBio. 2016;7(1):e01938-15.  https://doi.org/10.1128/mBio.01938-15  PMID: 26838717 
  6. Becker N, Jöst H, Ziegler U, Eiden M, Höper D, Emmerich P, et al. Epizootic emergence of Usutu virus in wild and captive birds in Germany. PLoS One. 2012;7(2):e32604.  https://doi.org/10.1371/journal.pone.0032604  PMID: 22389712 
  7. Weissenböck H, Kolodziejek J, Url A, Lussy H, Rebel-Bauder B, Nowotny N. Emergence of Usutu virus, an African mosquito-borne flavivirus of the Japanese encephalitis virus group, central Europe. Emerg Infect Dis. 2002;8(7):652-6.  https://doi.org/10.3201/eid0807.020094  PMID: 12095429 
  8. Rubel F, Brugger K, Hantel M, Chvala-Mannsberger S, Bakonyi T, Weissenböck H, et al. Explaining Usutu virus dynamics in Austria: model development and calibration. Prev Vet Med. 2008;85(3-4):166-86.  https://doi.org/10.1016/j.prevetmed.2008.01.006  PMID: 18314208 
  9. Cavrini F, Gaibani P, Longo G, Pierro AM, Rossini G, Bonilauri P, et al. Usutu virus infection in a patient who underwent orthotropic liver transplantation, Italy, August-September 2009. Euro Surveill. 2009;14(50):19448. PMID: 20070935 
  10. Pecorari M, Longo G, Gennari W, Grottola A, Sabbatini A, Tagliazucchi S, et al. First human case of Usutu virus neuroinvasive infection, Italy, August-September 2009. Euro Surveill. 2009;14(50):19446. PMID: 20070936 
  11. Grottola A, Marcacci M, Tagliazucchi S, Gennari W, Di Gennaro A, Orsini M, Monaco F, Marchegiano P, Marini V, Meacci M, Rumpianesi F, Lorusso A, Pecorari M, Savini G. Usutu virus infections in humans: a retrospective analysis in the municipality of Modena, Italy. Clin Microbiol Infect. 2016 Sep 24. pii: S1198-743X(16)30425-6.
  12. Haylock MR, Hofstra N, Klein Tank AMG, Klok EJ, Jones PD, New M. A European daily high-resolution gridded dataset of surface temperature and precipitation for 1950-2006. J Geophys Res Atmos. 2008;113(D20):D20119.  https://doi.org/10.1029/2008JD010201 
  13. R Core Team. R: A Language and Environment for Statistical Computing [Internet]. Vienna, Austria: R Foundation for Statistical Computing. [Accessed 31 Oct 2016]. Available from: https://www.R-project.org/
  14. Wickham H. The split-apply-combine strategy for data analysis. J Stat Softw. 2011;40(1):1-29.  https://doi.org/10.18637/jss.v040.i01  PMID: 27818617 
  15. Grolemund G, Wickham H. Dates and Times Made Easy with lubridate. J Stat Softw. 2011;40(3):1-25.  https://doi.org/10.18637/jss.v040.i03 
  16. Hijmans RJ. raster: Geographic Data Analysis and Modeling. [Accessed 31 Oct 2016]. Available from: http://CRAN.R-project.org/package=raster
  17. Keitt T. colorRamps: Builds color tables. 29 Oct 2012. Available from: http://CRAN.R-project.org/package=colorRamps
  18. South A. rworldmap: A New R package for Mapping Global Data. R J. 2011;3(1):35-43.
  19. Wickham H. ggplot2: elegant graphics for data analysis. New York: Springer; 2009. 213 p. Available from: http://had.co.nz/ggplot2.org/book
  20. Auguie B. gridExtra: functions in Grid graphics. 2016. Available from: http://CRAN.R-project.org/package=gridExtra
  21. Becker N, Jöst H, Ziegler U, Eiden M, Höper D, Emmerich P, et al. Epizootic emergence of Usutu virus in wild and captive birds in Germany. PLoS One. 2012;7(2):e32604.  https://doi.org/10.1371/journal.pone.0032604  PMID: 22389712 
  22. van den Brand JM, van Leeuwen M, Schapendonk CME, Simon JH, Haagmans BL, Osterhaus AD, et al. Metagenomic analysis of the viral flora of pine marten and European badger feces. J Virol. 2012;86(4):2360-5.  https://doi.org/10.1128/JVI.06373-11  PMID: 22171250 
  23. Garigliany M, Linden A, Gilliau G, Levy E, Sarlet M, Franssen M, et al. Usutu virus, Belgium, 2016. Infect Genet Evol. 2016;48:116-9.  https://doi.org/10.1016/j.meegid.2016.12.023  PMID: 28017913 
  24. Drummond AJ, Suchard MA, Xie D, Rambaut A. Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol Biol Evol. 2012;29(8):1969-73.  https://doi.org/10.1093/molbev/mss075  PMID: 22367748 
  25. Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59(3):307-21.  https://doi.org/10.1093/sysbio/syq010  PMID: 20525638 
  26. Darriba D, Taboada GL, Doallo R, Posada D. jModelTest 2: more models, new heuristics and parallel computing. Nat Methods. 2012;9(8):772.  https://doi.org/10.1038/nmeth.2109  PMID: 22847109 
  27. Cadar D, Bosch S, Jöst H, Börstler J, Garigliany MM, Becker N, et al. Putative Lineage of Novel African Usutu Virus, Central Europe. Emerg Infect Dis. 2015;21(9):1647-50.  https://doi.org/10.3201/eid2109.142026  PMID: 26291923 
  28. Ziegler U, Fast C, Eiden M, Bock S, Schulze C, Hoeper D, et al. Evidence for an independent third Usutu virus introduction into Germany. Vet Microbiol. 2016;192(192):60-6.  https://doi.org/10.1016/j.vetmic.2016.06.007  PMID: 27527765 
  29. Cadar D, Becker N, Campos RM, Börstler J, Jöst H, Schmidt-Chanasit J. Usutu virus in bats, Germany, 2013. Emerg Infect Dis. 2014;20(10):1771-3.  https://doi.org/10.3201/eid2010.140909  PMID: 25271769 
  30. Vilibic-Cavlek T, Kaic B, Barbic L, Pem-Novosel I, Slavic-Vrzic V, Lesnikar V, et al. First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak. Infection. 2014;42(4):689-95.  https://doi.org/10.1007/s15010-014-0625-1  PMID: 24793998 
  31. Peterson AT, Vieglais DA, Andreasen JK. Migratory birds modeled as critical transport agents for West Nile Virus in North America. Vector Borne Zoonotic Dis. 2003;3(1):27-37.  https://doi.org/10.1089/153036603765627433  PMID: 12804378 
  32. Rappole JH, Derrickson SR, Hubálek Z. Migratory birds and spread of West Nile virus in the Western Hemisphere. Emerg Infect Dis. 2000;6(4):319-28.  https://doi.org/10.3201/eid0604.000401  PMID: 10905964 
  33. Goldberg TL, Anderson TK, Hamer GL. West Nile virus may have hitched a ride across the Western United States on Culex tarsalis mosquitoes. Mol Ecol. 2010;19(8):1518-9.  https://doi.org/10.1111/j.1365-294X.2010.04578.x  PMID: 20456236 
  34. Bakonyi T, Ferenczi E, Erdélyi K, Kutasi O, Csörgő T, Seidel B, et al. Explosive spread of a neuroinvasive lineage 2 West Nile virus in Central Europe, 2008/2009. Vet Microbiol. 2013;165(1-2):61-70.  https://doi.org/10.1016/j.vetmic.2013.03.005  PMID: 23570864 
  35. Danis K, Papa A, Theocharopoulos G, Dougas G, Athanasiou M. Detsis, et al. Outbreak of West Nile virus infection in Greece, 2010. Emerg Infect Dis 2010; 17, 1868–1872. http://dx.doi.org/  https://doi.org/10.3201/eid1710.110525  PMID: 22000357 
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