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Abstract

Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14–48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20–27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4–1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations.

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/content/10.2807/1560-7917.ES.2017.22.44.17-00102
2017-11-02
2018-06-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.44.17-00102
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References

  1. Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011;17(5):880-2.  https://doi.org/10.3201/eid1705.101939  PMID: 21529401 
  2. Hills SL, Russell K, Hennessey M, Williams C, Oster AM, Fischer M, et al. Transmission of Zika virus through sexual contact with travelers to areas of ongoing transmission - continental United States, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(8):215-6.  https://doi.org/10.15585/mmwr.mm6508e2  PMID: 26937739 
  3. D’Ortenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B, Piorkowski G, et al. Evidence of sexual transmission of Zika virus. N Engl J Med. 2016;374(22):2195-8.  https://doi.org/10.1056/NEJMc1604449  PMID: 27074370 
  4. Calvet G, Aguiar RS, Melo ASO, Sampaio SA, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016;16(6):653-60.  https://doi.org/10.1016/S1473-3099(16)00095-5  PMID: 26897108 
  5. Enfissi A, Codrington J, Roosblad J, Kazanji M, Rousset D. Zika virus genome from the Americas. Lancet. 2016;387(10015):227-8.  https://doi.org/10.1016/S0140-6736(16)00003-9  PMID: 26775124 
  6. Faria NR, Azevedo RDSDS, Kraemer MUG, Souza R, Cunha MS, Hill SC, et al. Zika virus in the Americas: Early epidemiological and genetic findings. Science. 2016;352(6283):345-9.  https://doi.org/10.1126/science.aaf5036  PMID: 27013429 
  7. Pacheco O, Beltrán M, Nelson CA, Valencia D, Tolosa N, Farr SL, et al. Zika virus disease in Colombia - preliminary report. N Engl J Med. 2016;NEJMoa1604037.  https://doi.org/10.1056/NEJMoa1604037  PMID: 27305043 
  8. Lazear HM, Stringer EM, de Silva AM. The emerging Zika virus epidemic in the Americas: research priorities. JAMA. 2016;315(18):1945-6.  https://doi.org/10.1001/jama.2016.2899  PMID: 26963564 
  9. Daudens-Vaysse E, Ledrans M, Gay N, Ardillon V, Cassadou S, Najioullah F, et al. Zika emergence in the French Territories of America and description of first confirmed cases of Zika virus infection on Martinique, November 2015 to February 2016. Euro Surveill. 2016;21(28):30285.  https://doi.org/10.2807/1560-7917.ES.2016.21.28.30285  PMID: 27447300 
  10. Fauci AS, Morens DM. Zika virus in the Americas--yet another arbovirus threat. N Engl J Med. 2016;374(7):601-4.  https://doi.org/10.1056/NEJMp1600297  PMID: 26761185 
  11. Sanchez JD. Pan American Health Organization (PAHO)/World Health Organization (WHO). Regional Zika epidemiological update (Americas) 26 January, 2017. Washington/Geneva: PAHO/WHO; 2017. Available from: http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=37775&lang=fr
  12. de Araújo TVB, Rodrigues LC, de Alencar Ximenes RA, de Barros Miranda-Filho D, Montarroyos UR, de Melo APL, et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis. 2016;16(12):1356-63.  https://doi.org/10.1016/S1473-3099(16)30318-8  PMID: 27641777 
  13. Brasil P, Pereira JP Jr, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375(24):2321-34.  https://doi.org/10.1056/NEJMoa1602412  PMID: 26943629 
  14. Musso D, Baud D. Zika virus: time to move from case reports to case control. Lancet Infect Dis. 2016;16(6):620-1.  https://doi.org/10.1016/S1473-3099(16)00096-7  PMID: 26897106 
  15. Jouannic J-M, Friszer S, Leparc-Goffart I, Garel C, Eyrolle-Guignot D. Zika virus infection in French Polynesia. Lancet. 2016;387(10023):1051-2.  https://doi.org/10.1016/S0140-6736(16)00625-5  PMID: 26944027 
  16. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika virus associated with microcephaly. N Engl J Med. 2016;374(10):951-8.  https://doi.org/10.1056/NEJMoa1600651  PMID: 26862926 
  17. Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet. 2016;387(10033):2125-32.  https://doi.org/10.1016/S0140-6736(16)00651-6  PMID: 26993883 
  18. Panchaud A, Stojanov M, Ammerdorffer A, Vouga M, Baud D. Emerging role of Zika virus in adverse fetal and neonatal outcomes. Clin Microbiol Rev. 2016;29(3):659-94.  https://doi.org/10.1128/CMR.00014-16  PMID: 27281741 
  19. Freitas ARR, Napimoga MH, Donalisio MR. Could clinical symptoms be a predictor of complications in Zika virus infection? Lancet. 2016;388(10042):338.  https://doi.org/10.1016/S0140-6736(16)31104-7  PMID: 27477156 
  20. Cauchemez S, Besnard M, Garel C, Fontanet A, Mallet H-P. Could clinical symptoms be a predictor of complications in Zika virus infection? - Authors’ reply. Lancet. 2016;388(10042):338-9.  https://doi.org/10.1016/S0140-6736(16)31017-0  PMID: 27477157 
  21. Institut national de la statistique et des études économiques (Insee). Poursuite de la transition démographique en Guyane - légère inflexion de la natalité. [The continuing demographic transition in French Guiana – a slight inflection of the birth rate]. Cayenne: Insee; 2016. French. Available from: http://www.insee.fr/fr/themes/document.asp?reg_id=25&ref_id=23897
  22. Celllule de l’Institut de Veille Sanitaire en Régions (Cire) Antilles-Guyane. Situation épidémiologique du virus Zika aux Antilles Guyane. Situation épidémiologique. Point au 4 février 2016. [Epidemiological situation of Zika virus in the French West Indies. Epidemiological situation. Data from 4 February 2016]. Saint-Maurice: Santé publique France; 2016. French. Available from: http://www.invs.sante.fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-4-fevrier-2016
  23. Tortevoye P, Tuppin P, Carles G, Peneau C, Gessain A. Comparative trends of seroprevalence and seroincidence rates of human T cell lymphotropic virus type I and human immunodeficiency virus 1 in pregnant women of various ethnic groups sharing the same environment in French Guiana. Am J Trop Med Hyg. 2005;73(3):560-5. PMID: 16172481 
  24. de Laval F, Matheus S, Maquart M, Yvrard E, Barthes N, Combes C, et al. Prospective Zika virus disease cohort: systematic screening. Lancet. 2016;388(10047):868.  https://doi.org/10.1016/S0140-6736(16)31429-5  PMID: 27597462 
  25. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14(8):1232-9.  https://doi.org/10.3201/eid1408.080287  PMID: 18680646 
  26. Northridge ME. Public health methods--attributable risk as a link between causality and public health action. Am J Public Health. 1995;85(9):1202-4.  https://doi.org/10.2105/AJPH.85.9.1202  PMID: 7661224 
  27. Celllule de l’Institut de Veille Sanitaire en Régions (Cire) Antilles-Guyane. Situation épidémiologique du virus Zika aux Antilles Guyane. Situation épidémiologique. Point au 2 juin 2016. [Epidemiological situation of Zika virus in the French West Indies. Epidemiological situation. Data from 2 June 2016]. Saint-Maurice: Santé publique France; 2016. French. Available from: http://www.invs.sante.fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-2-juin-2016
  28. Rabe IB, Staples JE, Villanueva J, Hummel KB, Johnson JA, Rose L, et al. MTS. Interim guidance for interpretation of Zika virus antibody test results. MMWR Morb Mortal Wkly Rep. 2016;65(21):543-6.  https://doi.org/10.15585/mmwr.mm6521e1  PMID: 27254248 
  29. Flamand C, Quenel P, Ardillon V, Carvalho L, Bringay S, Teisseire M. The epidemiologic surveillance of dengue-fever in French Guiana: when achievements trigger higher goals. Stud Health Technol Inform. 2011;169:629-33. PMID: 21893824 
  30. Adams L, Bello-Pagan M, Lozier M, Ryff KR, Espinet C, Torres J, et al. Update: ongoing zika virus transmission - Puerto Rico, November 1, 2015-July 7, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(30):774-9.  https://doi.org/10.15585/mmwr.mm6530e1  PMID: 27490087 
  31. Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T, et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol. 2016;17(9):1102-8.  https://doi.org/10.1038/ni.3515  PMID: 27339099 
  32. Duffy MR, Chen T-H, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360(24):2536-43.  https://doi.org/10.1056/NEJMoa0805715  PMID: 19516034 
  33. Cerbino-Neto J, Mesquita EC, Souza TML, Parreira V, Wittlin BB, Durovni B, et al. Clinical manifestations of Zika virus infection, Rio de Janeiro, Brazil, 2015. Emerg Infect Dis. 2016;22(7):1318-20.  https://doi.org/10.3201/eid2207.160375  PMID: 27070847 
  34. Celllule de l’Institut de Veille Sanitaire en Régions (Cire) Antilles-Guyane. Situation épidémiologique du virus Zika aux Antilles Guyane. Point au 22 septembre 2016. [Epidemiological situation of Zika virus in the French West Indies. Data from 22 September 2016]. Saint-Maurice: Santé publique France; 2016. French. Available from: http://invs.santepubliquefrance.fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-22-septembre-2016
The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Claude+Flamand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Flamand Claude</a>, <a href="/search?value1=Camille+Fritzell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fritzell Camille</a>, <a href="/search?value1=S%C3%A9verine+Matheus&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matheus Séverine</a>, <a href="/search?value1=Maryvonne+Dueymes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dueymes Maryvonne</a>, <a href="/search?value1=Gabriel+Carles&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carles Gabriel</a>, <a href="/search?value1=Anne+Favre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Favre Anne</a>, <a href="/search?value1=Antoine+Enfissi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Enfissi Antoine</a>, <a href="/search?value1=Antoine+Adde&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Adde Antoine</a>, <a href="/search?value1=Magalie+Demar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Demar Magalie</a>, <a href="/search?value1=Mirdad+Kazanji&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kazanji Mirdad</a>, <a href="/search?value1=Simon+Cauchemez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cauchemez Simon</a>, <a href="/search?value1=Dominique+Rousset&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rousset Dominique</a></span>. The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(44):pii=17-00102. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00102" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00102</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Feb 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Jun 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.44.17-00102
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