- Claude Flamand1, Camille Fritzell1, Séverine Matheus2, Maryvonne Dueymes3, Gabriel Carles4, Anne Favre5, Antoine Enfissi2, Antoine Adde1, Magalie Demar3, Mirdad Kazanji1, Simon Cauchemez6,7,8,9, Dominique Rousset2,9
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View Affiliations Hide AffiliationsAffiliations: 1 Epidemiology unit, Institut Pasteur in French Guiana, Cayenne, French Guiana 2 National Reference Center for arboviruses, Institut Pasteur in French Guiana, Cayenne, French Guiana 3 Laboratory, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana 4 Gynaecology-Obstetrics Department, Centre Hospitalier de l’Ouest Guyanais, Saint-Laurent du Maroni, French Guiana 5 Neonatology Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana 6 Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Paris, France 7 Centre National de la Recherche Scientifique, URA3012, Paris, France 8 Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris, France 9 These authors contributed equally to the studyClaude Flamandcflamand pasteur-cayenne.fr
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Citation style for this article: Flamand Claude, Fritzell Camille, Matheus Séverine, Dueymes Maryvonne, Carles Gabriel, Favre Anne, Enfissi Antoine, Adde Antoine, Demar Magalie, Kazanji Mirdad, Cauchemez Simon, Rousset Dominique. The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016. Euro Surveill. 2017;22(44):pii=17-00102. https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00102 Received: 07 Feb 2017; Accepted: 29 Jun 2017
The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016
Abstract
Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14–48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20–27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4–1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations.

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