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Abstract

Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14–48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20–27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4–1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations.

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/content/10.2807/1560-7917.ES.2017.22.44.17-00102
2017-11-02
2019-03-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.44.17-00102
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The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Claude+Flamand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Flamand Claude</a>, <a href="/search?value1=Camille+Fritzell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fritzell Camille</a>, <a href="/search?value1=S%C3%A9verine+Matheus&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matheus Séverine</a>, <a href="/search?value1=Maryvonne+Dueymes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dueymes Maryvonne</a>, <a href="/search?value1=Gabriel+Carles&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carles Gabriel</a>, <a href="/search?value1=Anne+Favre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Favre Anne</a>, <a href="/search?value1=Antoine+Enfissi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Enfissi Antoine</a>, <a href="/search?value1=Antoine+Adde&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Adde Antoine</a>, <a href="/search?value1=Magalie+Demar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Demar Magalie</a>, <a href="/search?value1=Mirdad+Kazanji&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kazanji Mirdad</a>, <a href="/search?value1=Simon+Cauchemez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cauchemez Simon</a>, <a href="/search?value1=Dominique+Rousset&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rousset Dominique</a></span>. The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(44):pii=17-00102. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00102" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00102</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Feb 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Jun 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.44.17-00102
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