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Abstract

This study reports the presence of dengue virus RNA in longitudinally collected semen samples of a previously healthy Caucasian man, returning to Italy from Thailand with primary dengue fever, up to 37 days post-symptom onset, when viraemia and viruria were undetectable. This finding, coupled with the evidence of dengue virus negative-strand RNA, an indirect marker of ongoing viral replication, in the cellular fraction of semen, indicates a need to further investigate possible sexual transmission.

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/content/10.2807/1560-7917.ES.2018.23.18.18-00197
2018-05-03
2018-07-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.18.18-00197
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References

  1. Moureau G, Temmam S, Gonzalez JP, Charrel RN, Grard G, de Lamballerie X. A real-time RT-PCR method for the universal detection and identification of flaviviruses. Vector Borne Zoonotic Dis. 2007;7(4):467-77.  https://doi.org/10.1089/vbz.2007.0206  PMID: 18020965 
  2. Biava M, Caglioti C, Bordi L, Castilletti C, Colavita F, Quartu S, et al. Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient. PLoS Pathog. 2017;13(1):e1006065.  https://doi.org/10.1371/journal.ppat.1006065  PMID: 28056096 
  3. Biava M, Caglioti C, Castilletti C, Bordi L, Carletti F, Colavita F, et al. Persistence of ZIKV-RNA in the cellular fraction of semen is accompanied by a surrogate-marker of viral replication. Diagnostic implications for sexual transmission. New Microbiol. 2018;41(1):30-3. PMID: 29112766 
  4. Valderrama A, Díaz Y, López-Vergès S. Interaction of Flavivirus with their mosquito vectors and their impact on the human health in the Americas. Biochem Biophys Res Commun. 2017;492(4):541-7.  https://doi.org/10.1016/j.bbrc.2017.05.050  PMID: 28499872 
  5. Chye JK, Lim CT, Ng KB, Lim JM, George R, Lam SK. Vertical transmission of dengue. Clin Infect Dis. 1997;25(6):1374-7.  https://doi.org/10.1086/516126  PMID: 9431381 
  6. Chen LH, Wilson ME. Update on non-vector transmission of dengue: relevant studies with Zika and other flaviviruses. Trop Dis Travel Med Vaccines. 2016;2(1):15.  https://doi.org/10.1186/s40794-016-0032-y  PMID: 28883959 
  7. Mead PS, Hills SL, Brooks JT. Zika virus as a sexually transmitted pathogen. Curr Opin Infect Dis. 2018;31(1):39-44.  https://doi.org/10.1097/QCO.0000000000000414  PMID: 29176348 
  8. Kim CR, Counotte M, Bernstein K, Deal C, Mayaud P, Low N, et al. Sexual Transmission of Zika virus Expert Meeting participants. Investigating the sexual transmission of Zika virus. Lancet Glob Health. 2018;6(1):e24-5.  https://doi.org/10.1016/S2214-109X(17)30419-9  PMID: 29241605 
  9. D’Ortenzio E, Matheron S, de Lamballerie X, Hubert B, Piorkowski G, Maquart M, et al. Evidence of Sexual Transmission of Zika Virus. N Engl J Med. 2016;374(22):2195-8.  https://doi.org/10.1056/NEJMc1604449  PMID: 27074370 
  10. Joguet G, Mansuy JM, Matusali G, Hamdi S, Walschaerts M, Pavili L, et al. Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study. Lancet Infect Dis. 2017;17(11):1200-8.  https://doi.org/10.1016/S1473-3099(17)30444-9  PMID: 28838639 
  11. Bandeira AC, Campos GS, Rocha VF, Souza BS, Soares MB, Oliveira AA, et al. Prolonged shedding of Chikungunya virus in semen and urine: A new perspective for diagnosis and implications for transmission. IDCases. 2016;6:100-3.  https://doi.org/10.1016/j.idcr.2016.10.007  PMID: 27882301 
  12. Barbosa CM, Di Paola N, Cunha MP, Rodrigues-Jesus MJ, Araujo DB, Silveira VB, et al. Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil. Emerg Infect Dis. 2018;24(1):176-8.  https://doi.org/10.3201/eid2401.171310  PMID: 29058663 
  13. Iannetta M, Lalle E, Musso M, Carletti F, Scorzolini L, D’Abramo A, et al. Persistent detection of dengue virus RNA in vaginal secretion of a woman returning from Sri Lanka to Italy, April 2017. Euro Surveill. 2017;22(34):30600.  https://doi.org/10.2807/1560-7917.ES.2017.22.34.30600  PMID: 28857045 
  14. European Centre for Disease Prevention and Control (ECDC). Surveillance Atlas of Infectious Diseases. Stockhom: ECDC. [Accessed 02 May 2018]. Available from: https://ecdc.europa.eu/en/surveillance-atlas-infectious-diseases
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