1887
  1. Home
  2. Eurosurveillance
  3. Volume 23, Issue 29, 19/Jul/2018
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

A large outbreak of vancomycin-resistant enterococci (VRE) is affecting four hospitals in the Canton of Bern, Switzerland, since December 2017. Of 89 cases identified as carriers, 77 (86.5%) VRE isolates were virtually indistinguishable using whole genome sequencing, and identified as multilocus sequence type (MLST) ST796. This clone, previously only described in Australia and New Zealand, is characterised by rapid spread and the ability to cause bloodstream infections. It requires a multifaceted infection prevention effort.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2018.23.29.1800351
2018-07-19
2020-09-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.29.1800351
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/23/29/eurosurv-23-29-1.html?itemId=/content/10.2807/1560-7917.ES.2018.23.29.1800351&mimeType=html&fmt=ahah

References

  1. Rubinstein E, Keynan Y. Vancomycin-resistant enterococci. Crit Care Clin. 2013;29(4):841-52.  https://doi.org/10.1016/j.ccc.2013.06.006  PMID: 24094380 
  2. Prematunge C, MacDougall C, Johnstone J, Adomako K, Lam F, Robertson J, et al. VRE and VSE Bacteremia Outcomes in the Era of Effective VRE Therapy: A Systematic Review and Meta-analysis. Infect Control Hosp Epidemiol. 2016;37(1):26-35.  https://doi.org/10.1017/ice.2015.228  PMID: 26434609 
  3. Mahony AA, Buultjens AH, Ballard SA, Grabsch EA, Xie S, Seemann T, et al. Vancomycin-resistant Enterococcus faecium sequence type 796 - rapid international dissemination of a new epidemic clone. Antimicrob Resist Infect Control. 2018;7(1):44.  https://doi.org/10.1186/s13756-018-0335-z  PMID: 29588851 
  4. Leong KWC, Cooley LA, Anderson TL, Gautam SS, McEwan B, Wells A, et al. Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis. Sci Rep. 2018;8(1):6274.  https://doi.org/10.1038/s41598-018-24614-6  PMID: 29674657 
  5. Buultjens AH, Lam MM, Ballard S, Monk IR, Mahony AA, Grabsch EA, et al. Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium. PeerJ. 2017;5:e2916.  https://doi.org/10.7717/peerj.2916  PMID: 28149688 
  6. Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, et al. WHO Pathogens Priority List Working Group. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318-27.  https://doi.org/10.1016/S1473-3099(17)30753-3  PMID: 29276051 
  7. European Centre for Disease Prevention and Control (ECDC). Surveillance of antimicrobial resistance in Europe. Stockholm: ECDC; 2016. Available from: https://ecdc.europa.eu/sites/portal/files/documents/AMR-surveillance-Europe-2016.pdf
  8. Noskin GA, Stosor V, Cooper I, Peterson LR. Recovery of vancomycin-resistant enterococci on fingertips and environmental surfaces. Infect Control Hosp Epidemiol. 1995;16(10):577-81.  https://doi.org/10.2307/30141097  PMID: 8568202 
  9. Satilmis L, Vanhems P, Bénet T. Outbreaks of Vancomycin-Resistant Enterococci in Hospital Settings: A Systematic Review and Calculation of the Basic Reproductive Number. Infect Control Hosp Epidemiol. 2016;37(3):289-94.  https://doi.org/10.1017/ice.2015.301  PMID: 26669221 
  10. Mahony AAGE, Ballard SA, Wang J, Xie S, Roberts SA, Stuart RL, et al. Vancomycin-resistant Enterococcus faecium sequence type 796, the new trans-Tasman epidemic clone. In: Program and abstracts of the Australian Society for Antimicrobials - antimicrobials 2014 (Melbourne). Australian Society for Antimocrobials; 2014.
  11. Lister DM, Kotsanas D, Ballard SA, Howden BP, Carse E, Tan K, et al. Outbreak of vanB vancomycin-resistant Enterococcus faecium colonization in a neonatal service. Am J Infect Control. 2015;43(10):1061-5.  https://doi.org/10.1016/j.ajic.2015.05.047  PMID: 26190380 
  12. The Australian group on Antimicrobial Resistance (AGAR). Australian Enterococcal Sepsis Outcome Program (AESOP) 2016. Australia: AGAR; 2016. Available from: http://agargroup.org.au/wp-content/uploads/2017/08/AESOP-2016-Final-Report-2017.pdf
  13. Pidot SJ, Gao W, Buultjens AH, Monk IR, Guerillot R, Carter GP, et al. Increasing tolerance of hospital Enterococcus faecium to hand-wash alcohols. bioRxiv. 2016;053728
  14. de Been M, Pinholt M, Top J, Bletz S, Mellmann A, van Schaik W, et al. Core Genome Multilocus Sequence Typing Scheme for High- Resolution Typing of Enterococcus faecium. J Clin Microbiol. 2015;53(12):3788-97.  https://doi.org/10.1128/JCM.01946-15  PMID: 26400782 
Outbreak of vancomycin-resistant Enterococcus faecium clone ST796, Switzerland, December 2017 to April 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Nasstasja+Wassilew&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wassilew Nasstasja</a> , <a href="/search?value1=Helena+MB+Seth-Smith&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Seth-Smith Helena MB</a> , <a href="/search?value1=Eveline+Rolli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rolli Eveline</a> , <a href="/search?value1=Yvonne+Fietze&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fietze Yvonne</a> , <a href="/search?value1=Carlo+Casanova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Casanova Carlo</a> , <a href="/search?value1=Urs+F%C3%BChrer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Führer Urs</a> , <a href="/search?value1=Adrian+Egli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Egli Adrian</a> , <a href="/search?value1=Jonas+Marschall&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marschall Jonas</a> , <a href="/search?value1=Niccol%C3%B2+Buetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buetti Niccolò</a> </span>. Outbreak of vancomycin-resistant Enterococcus faecium clone ST796, Switzerland, December 2017 to April 2018. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(29):pii=1800351. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.29.1800351" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.29.1800351</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 02 Jul 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 19 Jul 2018 </span> </p>
/content/10.2807/1560-7917.ES.2018.23.29.1800351
/content/10.2807/1560-7917.ES.2018.23.29.1800351
Loading

Data & Media loading...

Supplementary data

  • Download

    • Table S1. List of isolates and associated genomic parameters

  • Download

    • Figure S1. Phylogeny of ST796 based on SNPs, relative to the reference sequence Ef_aus0233

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error