1887
Rapid communication Open Access
Like 0

Abstract

Since 7 June 2018, an enterovirus D-68 (EV-D68) season (the third since 2015) is ongoing in Wales, with 114 confirmed cases thus far. Median age of the 220 cases since 2015 is 2.5 years (2.5 years in intensive care cases), 94% were hospitalised, 17% (n = 38) in intensive care. All had respiratory symptoms; bronchiolitis symptoms were reported in 60 cases, severe respiratory symptoms in 23 and acute flaccid myelitis in two cases.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2018.23.46.1800578
2018-11-15
2018-12-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.46.1800578
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/23/46/eurosurv-23-46-2.html?itemId=/content/10.2807/1560-7917.ES.2018.23.46.1800578&mimeType=html&fmt=ahah

References

  1. Williams CJ, Thomas RH, Pickersgill TP, Lyons M, Lowe G, Stiff RE, et al. Cluster of atypical adult Guillain-Barré syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016. Euro Surveill. 2016;21(4):30119.  https://doi.org/10.2807/1560-7917.ES.2016.21.4.30119  PMID: 26848143 
  2. Poelman R, Schuffenecker I, Van Leer-Buter C, Josset L, Niesters HGM, Lina BESCV-ECDC EV-D68 study group. European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014. J Clin Virol. 2015;71:1-9.  https://doi.org/10.1016/j.jcv.2015.07.296  PMID: 26364237 
  3. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704.  https://doi.org/10.1128/JCM.00542-06  PMID: 16891480 
  4. Holm-Hansen CC, Midgley SE, Schjørring S, Fischer TK. The importance of enterovirus surveillance in a Post-polio world. Clin Microbiol Infect. 2017;23(6):352-4.  https://doi.org/10.1016/j.cmi.2017.02.010  PMID: 28216324 
  5. Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, et al. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. J Clin Virol. 2018;101:11-7.  https://doi.org/10.1016/j.jcv.2018.01.008  PMID: 29414181 
  6. Harvala H, Jasir A, Penttinen P, Pastore Celentano L, Greco D, Broberg E. Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016. Euro Surveill. 2017;22(45):16-00807.  https://doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807  PMID: 29162204 
  7. New York State Department of Health. NYS Department of Health Confirms Cases of Serious Respiratory Virus. New York: Department of Health; 2018. Available from: https://www.health.ny.gov/press/releases/2018/2018-10-12_enterovirus_ev_d68.htm
  8. Centers for Disease Control and Prevention (CDC). Transcript for CDC Telebriefing: Update on Acute Flaccid Myelitis (AFM) in the U.S. Atlanta: CDC; 2018. Available from: https://www.cdc.gov/media/releases/2018/t1016-flaccid-myelitis.html
  9. de Graaf H, Pelosi E, Cooper A, Pappachan J, Sykes K, MacIntosh I, et al. Severe Enterovirus Infections in Hospitalized Children in the South of England: Clinical Phenotypes and Causative Genotypes. Pediatr Infect Dis J. 2016;35(7):723-7.  https://doi.org/10.1097/INF.0000000000001093  PMID: 26882165 
  10. Kadambari S, Bukasa A, Okike IO, Pebody R, Brown D, Gallimore C, et al. Enterovirus infections in England and Wales, 2000-2011: the impact of increased molecular diagnostics. Clin Microbiol Infect. 2014;20(12):1289-96.  https://doi.org/10.1111/1469-0691.12753  PMID: 25039903 
  11. Midgley CM, Watson JT, Nix WA, Curns AT, Rogers SL, Brown BA, et al. EV-D68 Working Group. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation. Lancet Respir Med. 2015;3(11):879-87.  https://doi.org/10.1016/S2213-2600(15)00335-5  PMID: 26482320 
  12. Martin G, Li R, Cook VE, Carwana M, Tilley P, Sauve L, et al. Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak. Can Respir J. 2016;2016:8302179.
  13. Imamura T, Suzuki A, Meijer A, Niesters HGM, Rahamat-Langendoen JC, Lojo J, et al. Centers for Disease Control and Prevention (CDC). Clusters of acute respiratory illness associated with human enterovirus 68--Asia, Europe, and United States, 2008-2010. MMWR Morb Mortal Wkly Rep. 2011;60(38):1301-4. PMID: 21956405 
  14. Vazquez-Perez JA, Ramirez-Gonzalez JE, Moreno-Valencia Y, Hernandez-Hernandez VA, Romero-Espinoza JA, Castillejos-Lopez M, et al. EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn. Influenza Other Respi Viruses. 2016;10(3):154-60.  https://doi.org/10.1111/irv.12384  PMID: 26935868 
/content/10.2807/1560-7917.ES.2018.23.46.1800578
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error