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Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak
- Le Nguyen Thanh Nhan1 , Nguyen Thi Thu Hong2 , Le Nguyen Truc Nhu2 , Lam Anh Nguyet2 , Nguyen Thi Han Ny2 , Tran Tan Thanh2 , Do Duong Kim Han2 , Hoang Minh Tu Van2 , C Louise Thwaites2,3 , Tran Tinh Hien2,3 , Phan Tu Qui4 , Pham Van Quang1 , Ngo Ngoc Quang Minh1 , H. Rogier van Doorn2,3 , Truong Huu Khanh1 , Nguyen Van Vinh Chau4 , Guy Thwaites2,3 , Nguyen Thanh Hung1 , Le Van Tan2
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View Affiliations Hide AffiliationsAffiliations: 1 Children’s Hospital 1, Ho Chi Minh City, Vietnam 2 Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam 3 Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom 4 Hospital for Tropical Diseases, Ho Chi Minh City, VietnamLe Van Tantanlv oucru.org
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Citation style for this article: Nhan Le Nguyen Thanh, Hong Nguyen Thi Thu, Nhu Le Nguyen Truc, Nguyet Lam Anh, Ny Nguyen Thi Han, Thanh Tran Tan, Han Do Duong Kim, Van Hoang Minh Tu, Thwaites C Louise, Hien Tran Tinh, Qui Phan Tu, Quang Pham Van, Minh Ngo Ngoc Quang, van Doorn H. Rogier, Khanh Truong Huu, Chau Nguyen Van Vinh, Thwaites Guy, Hung Nguyen Thanh, Tan Le Van. Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak. Euro Surveill. 2018;23(46):pii=1800590. https://doi.org/10.2807/1560-7917.ES.2018.23.46.1800590 Received: 25 Oct 2018; Accepted: 15 Nov 2018
Abstract
Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011–12 among susceptible young children raises concern of another impending severe outbreak.
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