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Abstract

Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011–12 among susceptible young children raises concern of another impending severe outbreak.

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/content/10.2807/1560-7917.ES.2018.23.46.1800590
2018-11-15
2024-12-06
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.46.1800590
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References

  1. Ministry of Health (Vietnam). General Department of Preventive Medicine. Preventing hand, foot and mouth disease. Hanoi: Ministry of Health; Oct 2018. Vietnamese. Available from: http://vncdc.gov.vn/vi/tin-tuc-trong-nuoc/2361/chu-dong-phong-benh-tay-chan-mieng
  2. Khanh TH, Sabanathan S, Thanh TT, Thoa PK, Thuong TC, Hang V, et al. Enterovirus 71-associated hand, foot, and mouth disease, Southern Vietnam, 2011. Emerg Infect Dis. 2012;18(12):2002-5.  https://doi.org/10.3201/eid1812.120929  PMID: 23194699 
  3. Anh NT, Nhu LNT, Van HMT, Hong NTT, Thanh TT, Hang VTT, et al. Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam. Emerg Infect Dis. 2018;24(4):654-62.  https://doi.org/10.3201/eid2404.171298  PMID: 29553326 
  4. Thanh TT, Anh NT, Tham NT, Van HM, Sabanathan S, Qui PT, et al. Validation and utilization of an internally controlled multiplex Real-time RT-PCR assay for simultaneous detection of enteroviruses and enterovirus A71 associated with hand foot and mouth disease. Virol J. 2015;12(1):85.  https://doi.org/10.1186/s12985-015-0316-2  PMID: 26050791 
  5. Brown BA, Oberste MS, Alexander JP Jr, Kennett ML, Pallansch MA. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol. 1999;73(12):9969-75. PMID: 10559310 
  6. Tan V, Tuyen NT, Thanh TT, Ngan TT, Van HM, Sabanathan S, et al. A generic assay for whole-genome amplification and deep sequencing of enterovirus A71. J Virol Methods. 2015;215-216:30-6.  https://doi.org/10.1016/j.jviromet.2015.02.011  PMID: 25704598 
  7. Kroneman A, Vennema H, Deforche K, v d Avoort H, Peñaranda S, Oberste MS, et al. An automated genotyping tool for enteroviruses and noroviruses. J Clin Virol. 2011;51(2):121-5.  https://doi.org/10.1016/j.jcv.2011.03.006  PMID: 21514213 
  8. Gao L, Zou G, Liao Q, Zhou Y, Liu F, Dai B, et al. Spectrum of Enterovirus Serotypes Causing Uncomplicated Hand, Foot, and Mouth Disease and Enteroviral Diagnostic Yield of Different Clinical Samples. Clin Infect Dis. 2018;67(11):1729-35.  https://doi.org/10.1093/cid/ciy341  PMID: 29688329 
  9. Takahashi S, Metcalf CJE, Arima Y, Fujimoto T, Shimizu H, Rogier van Doorn H, et al. Epidemic dynamics, interactions and predictability of enteroviruses associated with hand, foot and mouth disease in Japan. J R Soc Interface. 2018;15(146):20180507.  https://doi.org/10.1098/rsif.2018.0507  PMID: 30209044 
  10. Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, et al. Hand, foot, and mouth disease in China, 2008-12: an epidemiological study. Lancet Infect Dis. 2014;14(4):308-18.  https://doi.org/10.1016/S1473-3099(13)70342-6  PMID: 24485991 
  11. Hassel C, Mirand A, Lukashev A, TerletskaiaLadwig E, Farkas A, Schuffenecker I, et al. Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013. Euro Surveill. 2015;20(34):30005.  https://doi.org/10.2807/1560-7917.ES.2015.20.34.30005  PMID: 26530407 
  12. Midgley SE, Nielsen AG, Trebbien R, Poulsen MW, Andersen PH, Fischer TK. Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016. Euro Surveill. 2017;22(26):30565.  https://doi.org/10.2807/1560-7917.ES.2017.22.26.30565  PMID: 28681718 
  13. Antona D, Kossorotoff M, Schuffenecker I, Mirand A, Leruez-Ville M, Bassi C, et al. Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016. Euro Surveill. 2016;21(46):30402.  https://doi.org/10.2807/1560-7917.ES.2016.21.46.30402  PMID: 27918268 
  14. World Heatlh Organization (WHO). China produces world’s first vaccine against virus that causes Hand, Foot and Mouth Disease. Geneva: WHO; Dec 2015. Available from: http://www.wpro.who.int/china/mediacentre/releases/2015/20151208/en/
  15. Mao QY, Wang Y, Bian L, Xu M, Liang Z. EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD). Expert Rev Vaccines. 2016;15(5):599-606.  https://doi.org/10.1586/14760584.2016.1138862  PMID: 26732723 
  16. Chea S, Cheng YB, Chokephaibulkit K, Chotpitayasunondh T, Rogier van Doorn H, Hafy Z, et al. Workshop on use of intravenous immunoglobulin in hand, foot and mouth disease in Southeast Asia. Emerg Infect Dis. 2015;21(1).  https://doi.org/10.3201/eid2101.140992  PMID: 25531166 
  17. World Health Organization (WHO). Poliomyelitis. Geneva: WHO; Mar 2018. Available from: http://www.who.int/news-room/fact-sheets/detail/poliomyelitis
  18. World Health Organization (WHO). List of Blueprint Priority Diseases. Geneva: WHO. [Accessed 8 Nov 2018]. Available from: https://www.who.int/blueprint/priority-diseases/en/
  19. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis. 2010;10(11):778-90.  https://doi.org/10.1016/S1473-3099(10)70194-8  PMID: 20961813 
  20. Geoghegan JL, Tan V, Kühnert D, Halpin RA, Lin X, Simenauer A, et al. Phylodynamics of enterovirus A71-associated hand, foot, and mouth disease in Viet Nam. J Virol. 2015;89(17):8871-9.  https://doi.org/10.1128/JVI.00706-15  PMID: 26085170 
  21. World Heatlh Organization (WHO). Hand, Foot and Mouth Disease Situation Update (Archives 2015, 2016 and 2017). Geneva: WHO. Available from: http://www.who.int/westernpacific/emergencies/surveillance/archives/hand-foot-and-mouth-disease
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