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Abstract

Background

Given that measles is eliminated in Canada and measles immunisation coverage in Ontario is high, it has been questioned whether Ontario’s measles outbreak response is worthwhile.

Aim

Our objective was to determine cost-effectiveness of measles containment protocols in Ontario from the healthcare payer perspective.

Methods

We developed a decision-analysis model comparing Ontario’s measles containment strategy (based on actual 2015 outbreak data) with a hypothetical ‘modified response’. The modified scenario assumed 10% response costs with reduced case and contact tracing and no outbreak-associated vaccinations; it was based on local and provincial administrative and laboratory data and parameters from peer-reviewed literature. Short- and long-term health outcomes, quality-adjusted life years (QALYs) and costs discounted at 1.5%, were estimated. We conducted one- and two-way sensitivity analyses.

Results

The 2015 outbreak in Ontario comprised 16 measles cases and an estimated 3,369 contacts. Predictive modelling suggested that the outbreak response prevented 16 outbreak-associated cases at a cost of CAD 1,213,491 (EUR 861,579). The incremental cost-effectiveness ratio was CAD 739,063 (EUR 524,735) per QALY gained for the outbreak response vs modified response. To meet the commonly accepted cost-effectiveness threshold of CAD 50,000 (EUR 35,500) per QALY gained, the outbreak response would have to prevent 94 measles cases. In sensitivity analyses, the findings were robust.

Conclusions

Ontario’s measles outbreak response exceeds generally accepted cost-effectiveness thresholds and may not be the most efficient use of public health resources from a healthcare payer perspective. These findings should be balanced against benefits of increased vaccine coverage and maintaining elimination status.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2019.24.11.1800370
2019-03-14
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.11.1800370
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Cost-effectiveness of measles control during elimination in Ontario, Canada, 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Lauren+C+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Lauren C</a>, <a href="/search?value1=Natasha+S+Crowcroft&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crowcroft Natasha S</a>, <a href="/search?value1=Shari+Thomas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thomas Shari</a>, <a href="/search?value1=Elena+Aruffo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aruffo Elena</a>, <a href="/search?value1=Alexandra+Teslya&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Teslya Alexandra</a>, <a href="/search?value1=Jane+M+Heffernan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Heffernan Jane M</a>, <a href="/search?value1=Effie+Gournis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gournis Effie</a>, <a href="/search?value1=Joanne+Hiebert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hiebert Joanne</a>, <a href="/search?value1=Valerie+Jaeger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jaeger Valerie</a>, <a href="/search?value1=Manisa+Jiaravuthisan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jiaravuthisan Manisa</a>, <a href="/search?value1=Jennifer+Sharron&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sharron Jennifer</a>, <a href="/search?value1=Alberto+Severini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Severini Alberto</a>, <a href="/search?value1=Shelley+L+Deeks&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deeks Shelley L</a>, <a href="/search?value1=Jonathan+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan</a>, <a href="/search?value1=Tony+Mazzulli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mazzulli Tony</a>, <a href="/search?value1=Beate+Sander&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sander Beate</a></span>. Cost-effectiveness of measles control during elimination in Ontario, Canada, 2015. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(11):pii=1800370. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.11.1800370" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.11.1800370</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Jul 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 19 Dec 2018 </span> </p>
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