1887
Rapid communication Open Access
Like 0

Abstract

In January 2019, a human seasonal reassortant influenza A(H1N2) virus with a novel 7:1 genetic constellation was identified in a 68-year-old female patient with suspected pneumonia. The virus harboured A(H3N2) neuraminidase and remaining genes from A(H1N1)pdm09. The patient recovered after severe illness. No additional cases have been detected. This is the second identified A(H1N2) seasonal reassortant in a human in Europe within 1 year; a previous case was detected in the Netherlands in March 2018.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2019.24.9.1900124
2019-02-28
2019-03-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.9.1900124
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/24/9/eurosurv-24-9-2.html?itemId=/content/10.2807/1560-7917.ES.2019.24.9.1900124&mimeType=html&fmt=ahah

References

  1. Emborg HD, Krause TG, Nielsen L, Thomsen MK, Christiansen CB, Skov MN, et al. Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment. Euro Surveill. 2016;21(14):30189. PMID: 27101732 
  2. Elbe S, Buckland-Merrett G. Data, disease and diplomacy: GISAID’s innovative contribution to global health. Global Challenges.2017;1(1):33-46.
  3. Shu Y, McCauley J. GISAID: Global initiative on sharing all influenza data - from vision to reality. Euro Surveill. 2017;22(13):30494. PMID: 28382917 
  4. Myers CA, Kasper MR, Yasuda CY, Savuth C, Spiro DJ, Halpin R, et al. Dual infection of novel influenza viruses A/H1N1 and A/H3N2 in a cluster of Cambodian patients. Am J Trop Med Hyg. 2011;85(5):961-3.  https://doi.org/10.4269/ajtmh.2011.11-0098  PMID: 22049058 
  5. Liu W, Li ZD, Tang F, Wei MT, Tong YG, Zhang L, et al. Mixed infections of pandemic H1N1 and seasonal H3N2 viruses in 1 outbreak. Clin Infect Dis. 2010;50(10):1359-65.  https://doi.org/10.1086/652143  PMID: 20380566 
  6. Frank AL, Taber LH, Wells JM. Individuals infected with two subtypes of influenza A virus in the same season. J Infect Dis. 1983;147(1):120-4.  https://doi.org/10.1093/infdis/147.1.120  PMID: 6822747 
  7. Falchi A, Arena C, Andreoletti L, Jacques J, Leveque N, Blanchon T, et al. Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France. J Clin Virol. 2008;41(2):148-51.  https://doi.org/10.1016/j.jcv.2007.11.003  PMID: 18069055 
  8. Rith S, Chin S, Sar B, P Y, Horm SV, Ly S, et al. Natural co-infection of influenza A/H3N2 and A/H1N1pdm09 viruses resulting in a reassortant A/H3N2 virus. J Clin Virol. 2015;73:108-11.  https://doi.org/10.1016/j.jcv.2015.11.008  PMID: 26590689 
  9. Gregory V, Bennett M, Orkhan MH, Al Hajjar S, Varsano N, Mendelson E, et al. Emergence of influenza A H1N2 reassortant viruses in the human population during 2001. Virology. 2002;300(1):1-7.  https://doi.org/10.1006/viro.2002.1513  PMID: 12202200 
  10. Mukherjee TR, Agrawal AS, Chakrabarti S, Chawla-Sarkar M. Full genomic analysis of an influenza A (H1N2) virus identified during 2009 pandemic in Eastern India: evidence of reassortment event between co-circulating A(H1N1)pdm09 and A/Brisbane/10/2007-like H3N2 strains. Virol J. 2012;9(1):233.  https://doi.org/10.1186/1743-422X-9-233  PMID: 23057530 
  11. Mizuta K, Katsushima N, Ito S, Sanjoh K, Murata T, Abiko C, et al. A rare appearance of influenza A(H1N2) as a reassortant in a community such as Yamagata where A(H1N1) and A(H3N2) co-circulate. Microbiol Immunol. 2003;47(5):359-61.  https://doi.org/10.1111/j.1348-0421.2003.tb03407.x  PMID: 12825897 
  12. Li XS, Zhao CY, Gao HM, Zhang YQ, Ishida M, Kanegae Y, et al. Origin and evolutionary characteristics of antigenic reassortant influenza A (H1N2) viruses isolated from man in China. J Gen Virol. 1992;73(Pt 6):1329-37. PMID: 1607856 
  13. Guo YJ, Xu XY, Cox NJ. Human influenza A (H1N2) viruses isolated from China. J Gen Virol. 1992;73(Pt 2):383-7. PMID: 1538194 
  14. Chen MJ, La T, Zhao P, Tam JS, Rappaport R, Cheng SM. Genetic and phylogenetic analysis of multi-continent human influenza A(H1N2) reassortant viruses isolated in 2001 through 2003. Virus Res. 2006;122(1-2):200-5.  https://doi.org/10.1016/j.virusres.2006.07.010  PMID: 16971014 
  15. Meijer A, Swaan CM, Voerknecht M, Jusic E, van den Brink S, Wijsman LA, et al. Case of seasonal reassortant A(H1N2) influenza virus infection, the Netherlands, March 2018. Euro Surveill. 2018;23(15):18-00160.  https://doi.org/10.2807/1560-7917.ES.2018.23.15.18-00160  PMID: 29667576 
  16. Skowronski DM, Leir S, Sabaiduc S, Murti M, Dickinson JA, Olsha R, et al. Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019. Euro Surveill. 2019;24(4):1900055.  https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055  PMID: 30696523 
  17. Chiu SS, Kwan MYW, Feng S, Chan ELY, Chua H, Wong JSC, et al. Early season estimate of influenza vaccination effectiveness against influenza hospitalisation in children, Hong Kong, winter influenza season 2018/19. Euro Surveill. 2019;24(5):1900056.  https://doi.org/10.2807/1560-7917.ES.2019.24.5.1900056  PMID: 30722814 
  18. Kissling E, Rose A, Emborg HD, Gherasim A, Pebody R, Pozo F, et al. Interim 2018/19 influenza vaccine effectiveness: six European studies, October 2018 to January 2019. Euro Surveill. 2019;24(8):1900121.
  19. Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol Biol Evol. 2016;33(7):1870-4.  https://doi.org/10.1093/molbev/msw054  PMID: 27004904 
/content/10.2807/1560-7917.ES.2019.24.9.1900124
Loading

Data & Media loading...

Supplementary data

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error