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Abstract

Background

Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging or even a probable re-emerging pathogen in southern Europe. Presence of this virus had been reported previously in Spain in 2010.

Aim

We aimed to evaluate the potential circulation of CCHFV in western Spain with a serosurvey in asymptomatic adults (blood donors).

Methods

During 2017 and 2018, we conducted a CCHFV serosurvey in randomly selected asymptomatic blood donors from western Spain. Three assays using specific IgG antibodies against CCHFV were performed: the VectoCrimea ELISA test, an in-house ELISA and indirect immunofluorescence (EuroImmun) test with glycoprotein and nucleoprotein.

Results

A total of 516 blood donors participated in this cross-sectional study. The majority of the study participants were male (68.4%), and the mean age was 46.3 years. Most of the participants came from rural areas (86.8%) and 68.6% had contact with animals and 20.9% had animal husbandry practices. One in five participants (109/516, 21.1%) were engaged in at-risk professional activities such as agriculture and shepherding, slaughtering, hunting, veterinary and healthcare work (mainly nursing staff and laboratory technicians). A total of 15.3% of the participants were bitten by ticks in the days or months before the date of sampling. We detected anti-CCHFV IgG antibodies with two diagnostic assays in three of the 516 individuals and with one diagnostic assay in six of the 516 individuals.

Conclusion

Seroprevalence of CCHFV was between 0.58% and 1.16% in Castile-León, Spain. This is the first study in western Spain that showed circulation of CCHFV in healthy people.

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/content/10.2807/1560-7917.ES.2020.25.10.1900507
2020-03-12
2024-04-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.10.1900507
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Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=L%C3%ADa+Monsalve+Arteaga&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monsalve Arteaga Lía</a>, <a href="/search?value1=Juan+Luis+Mu%C3%B1oz+Bellido&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muñoz Bellido Juan Luis</a>, <a href="/search?value1=Mar%C3%ADa+Carmen+Vieira+Lista&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vieira Lista María Carmen</a>, <a href="/search?value1=Mar%C3%ADa+Bel%C3%A9n++Vicente+Santiago&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vicente Santiago María Belén </a>, <a href="/search?value1=Pedro+Fern%C3%A1ndez+Soto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fernández Soto Pedro</a>, <a href="/search?value1=Isabel+Bas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bas Isabel</a>, <a href="/search?value1=Nuria+Leralta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leralta Nuria</a>, <a href="/search?value1=Fernando+de+Ory+Manch%C3%B3n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Ory Manchón Fernando</a>, <a href="/search?value1=Ana+Isabel+Negredo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Negredo Ana Isabel</a>, <a href="/search?value1=Mar%C3%ADa+Paz+S%C3%A1nchez+Seco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sánchez Seco María Paz</a>, <a href="/search?value1=Montserrat+Alonso+Sard%C3%B3n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alonso Sardón Montserrat</a>, <a href="/search?value1=Sonia+P%C3%A9rez+Gonz%C3%A1lez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez González Sonia</a>, <a href="/search?value1=Ana+Jim%C3%A9nez+del+Bianco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jiménez del Bianco Ana</a>, <a href="/search?value1=Lydia+Blanco+Peris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blanco Peris Lydia</a>, <a href="/search?value1=Rufino+Alamo-Sanz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alamo-Sanz Rufino</a>, <a href="/search?value1=Roger+Hewson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hewson Roger</a>, <a href="/search?value1=Moncef+Belhassen-Garc%C3%ADa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Belhassen-García Moncef</a>, <a href="/search?value1=Antonio+Muro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muro Antonio</a></span>. Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(10):pii=1900507. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.10.1900507" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.10.1900507</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 05 Aug 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 Dec 2019 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.10.1900507
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