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Abstract

Background

Influenza A(H1N1)pdm09, A(H3N2) and B viruses were co-circulating in Europe between September 2019 and January 2020.

Aim

To provide interim 2019/20 influenza vaccine effectiveness (VE) estimates from six European studies, covering 10 countries and both primary care and hospital settings.

Methods

All studies used the test-negative design, although there were some differences in other study characteristics, e.g. patient selection, data sources, case definitions and included age groups. Overall and influenza (sub)type-specific VE was estimated for each study using logistic regression adjusted for potential confounders.

Results

There were 31,537 patients recruited across the six studies, of which 5,300 (17%) were cases with 5,310 infections. Most of these (4,466; 84%) were influenza A. The VE point estimates for all ages were 29% to 61% against any influenza in the primary care setting and 35% to 60% in hospitalised older adults (aged 65 years and over). The VE point estimates against A(H1N1)pdm09 (all ages, both settings) was 48% to 75%, and against A(H3N2) ranged from −58% to 57% (primary care) and −16% to 60% (hospital). Against influenza B, VE for all ages was 62% to 83% (primary care only).

Conclusions

Influenza vaccination is of continued benefit during the ongoing 2019/20 influenza season. Robust end-of-season VE estimates and genetic virus characterisation results may help understand the variability in influenza (sub)type-specific results across studies.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2020-03-12
2022-10-02
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.10.2000153
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Interim 2019/20 influenza vaccine effectiveness: six European studies, September 2019 to January 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Angela+Rose&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rose Angela</a>, <a href="/search?value1=Esther+Kissling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kissling Esther</a>, <a href="/search?value1=Hanne-Dorthe+Emborg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Emborg Hanne-Dorthe</a>, <a href="/search?value1=Amparo+Larrauri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larrauri Amparo</a>, <a href="/search?value1=Jim+McMenamin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McMenamin Jim</a>, <a href="/search?value1=Francisco+Pozo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pozo Francisco</a>, <a href="/search?value1=Ramona+Trebbien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trebbien Ramona</a>, <a href="/search?value1=Clara+Mazagatos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mazagatos Clara</a>, <a href="/search?value1=Heather+Whitaker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Whitaker Heather</a>, <a href="/search?value1=Marta+Valenciano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valenciano Marta</a>, <a href="/search?value1=European+IVE+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">European IVE group</a></span>. Interim 2019/20 influenza vaccine effectiveness: six European studies, September 2019 to January 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(10):pii=2000153. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.10.2000153" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.10.2000153</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Feb 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Mar 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.10.2000153
/content/10.2807/1560-7917.ES.2020.25.10.2000153
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