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Abstract

Background

Several studies have investigated a possible association between respiratory infection and acute myocardial infarction (MI). As both influenza and pneumococcal infections are vaccine preventable, understanding the populations affected by virus-induced cardiovascular complications is important to guide public health and clinical practice.

Aim

This observational study aimed to quantify the association between laboratory-confirmed respiratory bacteria or virus infections and risk of first MI or stroke, by using self-controlled case series (SCCS) analysis of anonymised linked electronic Danish health records.

Methods

The SCCS method was used to determine the relative incidence of the first event of MI and stroke occurring within 28 days after laboratory-confirmed respiratory infections compared with the baseline time period.

Results

In the age and season adjusted analyses for first acute MI, the incidence ratios (IR) of a MI event occurring during the risk period were significantly elevated following a infection with values of 20.1, 11.0 and 4.9 during 1–3, 4–7 and 8–14 days, respectively and following respiratory virus infection with values of 15.2, 4.5 and 4.4 during 1–3, 8–14 and 15–28 days, respectively. The significantly elevated IRs for stroke following an infection were 25.5 and 6.3 during 1–3 and 8–14 days, respectively and following respiratory virus infection 8.3, 7.8 and 6.2 during 1–3, 4–7 and 8–14 days, respectively.

Conclusion

This study suggested a significant cardiovascular event triggering effect following infection with and respiratory viruses (mainly influenza), indicating the importance of protection against vaccine-preventable respiratory infections.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2020.25.17.1900199
2020-04-30
2024-04-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.17.1900199
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Acute myocardial infarctions and stroke triggered by laboratory-confirmed respiratory infections in Denmark, 2010 to 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Jessica+Ohland&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ohland Jessica</a>, <a href="/search?value1=Charlotte+Warren-Gash&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Warren-Gash Charlotte</a>, <a href="/search?value1=Ruth+Blackburn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blackburn Ruth</a>, <a href="/search?value1=K%C3%A5re+M%C3%B8lbak&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mølbak Kåre</a>, <a href="/search?value1=Palle+Valentiner-Branth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valentiner-Branth Palle</a>, <a href="/search?value1=Jens+Nielsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nielsen Jens</a>, <a href="/search?value1=Hanne-Dorthe+Emborg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Emborg Hanne-Dorthe</a></span>. Acute myocardial infarctions and stroke triggered by laboratory-confirmed respiratory infections in Denmark, 2010 to 2016. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(17):pii=1900199. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.17.1900199" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.17.1900199</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Mar 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Mar 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.17.1900199
/content/10.2807/1560-7917.ES.2020.25.17.1900199
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