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A serosurvey of IgG antibodies against severe acute respiratory coronavirus 2 (SARS-CoV-2) was performed during March and April 2020. Among 6,586 leftover sera, 24 (0.36%) were positive, with higher prevalence in females, older individuals and residents of large urban areas. Seroprevalence was estimated at 0.02% and 0.25%, respectively, in March and April, infection fatality rate at 2.66% and 0.54%. Our findings confirm low COVID-19 incidence in Greece and possibly the effectiveness of early measures.


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  1. Greek Ministry of Education and Religious Affairs. 10-03-20 Προσωρινή απαγόρευση της εκπαιδευτικής λειτουργίας όλων των εκπαιδευτικών δομών [Temporary ban on the operation of all educational structures].Athens: Greek Ministry of Education and Religious Affairs; 10 Mar 2020. Greek. Available from: https://www.minedu.gov.gr/news/44308-10-03-20-prosorini-apagorefsi-tis-ekpaideftikis-leitourgias-olon-ton-ekpaideftikon-domon
  2. European Union Agency for Fundamental Rights (FRA). Coronavirus COVID-19 outbreak in the EU Fundamental Rights Implications. Vienna: FRA; 23 Mar 2020. Available from: https://fra.europa.eu/sites/default/files/fra_uploads/greece-report-covid-19-april-2020_en.pdf
  3. National Public Health Organization (NPHO). Hμερήσια έκθεση επιδημιολογικής επιτήρησηςλοίμωξης από το νέο κορωνοϊό (COVID-19) Δεδομένα έως 30 Aπριλίου 2020. [Daily report of epidemiological surveillance of new coronavirus disease (COVID-19). Data until 30 April 2020]. Marousi: NPHO; 2020. Greek. Available from: https://eody.gov.gr/wp-content/uploads/2020/04/covid-gr-daily-report-20200430.pdf
  4. European Centre for Disease Prevention and Control (ECDC). COVID-19 situation update for the EU/EEA and the UK, as of 11 July 2020. Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/en/cases-2019-ncov-eueea
  5. Nardone A, Miller E, ESEN2 Group. Serological surveillance of rubella in Europe: European Sero-Epidemiology Network (ESEN2). Euro Surveill. 2004;9(4):5-7.  https://doi.org/10.2807/esm.09.04.00456-en  PMID: 15192256 
  6. Naing NN. Easy way to learn standardization : direct and indirect methods. Malays J Med Sci. 2000;7(1):10-5. PMID: 22844209 
  7. Bendavid E, Mulaney B, Sood N, Shah S, Ling E, Bromley-Dulfano R, et al. COVID-19 antibody seroprevalence in Santa Clara County, California. medRxiv 2020.04.14.20062463. https://doi.org/10.1101/2020.04.14.20062463
  8. MacMahon B, Trichopoulos D. Epidemiology: principles and methods: Boston: Little, Brown and Company; 1996.
  9. Diggle PJ. Estimating prevalence using an imperfect test. Epidemiol Res Int. 2011;2011:608719.  https://doi.org/10.1155/2011/608719 
  10. Campbell I. Chi-squared and Fisher-Irwin tests of two-by-two tables with small sample recommendations. Stat Med. 2007;26(19):3661-75.  https://doi.org/10.1002/sim.2832  PMID: 17315184 
  11. Our World in Data. Daily COVID-19 tests per thousand people -Greece Oxford: University of Oxford; 2020. Available from: https://ourworldindata.org/coronavirus-testing#greece
  12. World Health Organization (WHO). Population-based age-stratified seroepidemiological investigation protocol for COVID-19 virus infection, 17 March 2020. Geneva: WHO; 2020. Available from: https://apps.who.int/iris/handle/10665/331656
  13. Pollán M, Pérez-Gómez B, Pastor-Barriuso R, Oteo J, Hernán MA, Pérez-Olmeda M, et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet. 2020.
  14. Stringhini S, Wisniak A, Piumatti G, Azman AS, Lauer SA, Baysson H, et al. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study. Lancet. 2020;S0140-6736(20)31304-0. Ahead of print.
  15. European Centre for Disease Prevention and Control (ECDC). COVID-19 surveillance report. Stockholm: ECDC; 2020. [Accessed: 10 July 2020]. Available from: https://covid19-surveillance-report.ecdc.europa.eu/#age-sex-pyramids
  16. World Health Organization (WHO). Transmission of SARS-CoV-2: implications for infection prevention precautions. Geneva: WHO; 9 Jul 2020. Available from: https://www.who.int/news-room/commentaries/detail/transmission-of-sars-cov-2-implications-for-infection-prevention-precautions

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