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Abstract

We analysed 5,484 close contacts of coronavirus disease (COVID-19) cases in Italy, all tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection fatality ratio was 0.43% (95% confidence interval (CI): 0.21–0.79) for individuals younger than 70 years and 10.5% (95% CI: 8.0–13.6) for older individuals. Risk of death after infection was 62% lower (95% CI: 31–80) in clusters identified after 16 March 2020 and 1.8-fold higher for males (95% CI: 1.03–3.16).

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/content/10.2807/1560-7917.ES.2020.25.31.2001383
2020-08-06
2020-09-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.31.2001383
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References

  1. Okell LC, Verity R, Watson OJ, Mishra S, Walker P, Whittaker C, et al. Have deaths from COVID-19 in Europe plateaued due to herd immunity? Lancet. 2020;395(10241):e110-1.  https://doi.org/10.1016/S0140-6736(20)31357-X  PMID: 32534627 
  2. Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20(6):669-77.  https://doi.org/10.1016/S1473-3099(20)30243-7  PMID: 32240634 
  3. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA. 2020;323(16):1574-81.  https://doi.org/10.1001/jama.2020.5394  PMID: 32250385 
  4. Meyerowitz-Katz G and Merone L (2020) A systematic review and meta-analysis of published research data on COVID-19 infection-fatality rates. medRxiv. 2020. Available from: https://doi.org/10.1101/2020.05.03.20089854
  5. Cereda D, Tirani M, Rovida F, Demicheli V, Ajelli M, Poletti P, et al. The early phase of the COVID-19 outbreak in Lombardy, Italy. arXiv. 2020. Available from: https://arxiv.org/abs/2003.09320
  6. Bonelli F, Sarasini A, Zierold C, Calleri M, Bonetti A, Vismara C, et al. Clinical and analytical performance of an automated serological test that identifies S1/S2 neutralizing IgG In Covid-19 patients semiquantitatively. J Clin Microbiol. 2020;JCM.01224-20:JCM.01224-20.  https://doi.org/10.1128/JCM.01224-20  PMID: 32580948 
  7. Rajgor DD, Lee MH, Archuleta S, Bagdasarian N, Quek SC. The many estimates of the COVID-19 case fatality rate. Lancet Infect Dis. 2020;20(7):776-7.  https://doi.org/10.1016/S1473-3099(20)30244-9  PMID: 32224313 
  8. Poletti P, Tirani M, Cereda D, Trentini F, Guzzetta G, Sabatino G, et al. Probability of symptoms and critical disease after SARS-CoV-2 infection. arXiv. 2020. Available from: https://arxiv.org/abs/2006.08471
  9. Buitrago-Garcia DC, Egli-Gany D, Counotte MJ, Hossmann S, Imeri H, Salanti G, et al. The role of asymptomatic SARS-CoV-2 infections: rapid living systematic review and meta-analysis. medRxiv. 2020. Available from: https://doi.org/10.1101/2020.04.25.20079103
  10. Russell TW, Hellewell J, Jarvis CI, van Zandvoort K, Abbott S, Ratnayake R, et al. Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship, February 2020. Euro Surveill. 2020;25(12):2000256.  https://doi.org/10.2807/1560-7917.ES.2020.25.12.2000256  PMID: 32234121 
  11. Erikstrup C, Hother CE, Pedersen OBV, Mølbak K, Skov RL, Holm DK, et al. Estimation of SARS-CoV-2 infection fatality rate by real-time antibody screening of blood donors. medRxiv. 2020. Available from: https://doi.org/10.1101/2020.04.24.20075291
  12. Perez-Saez J, Lauer SA, Kaiser L, Regard S, Delaporte E, Guessous I, et al. Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland. Lancet Infect Dis. 2020;S1473-3099(20)30584-3.  https://doi.org/10.1016/S1473-3099(20)30584-3  PMID: 32679085 
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