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Abstract

Rabies is enzootic in over one hundred countries worldwide. In the European Union/European Economic Area (EU/EEA), the vast majority of human rabies cases are travellers bitten by dogs in rabies-enzootic countries, mostly in Asia and Africa. Thus, EU/EEA travellers visiting rabies enzootic countries should be aware of the risk of being infected with the rabies virus when having physical contact with mammals. They should consider pre-exposure vaccination following criteria recommended by the World Health Organization and if unvaccinated, immediately seek medical attention in case of bites or scratches from mammals. As the majority of the EU/EEA countries are free from rabies in mammals, elimination of the disease (no enzootic circulation of the virus and low number of imported cases) has been achieved by 2020. However, illegal import of potentially infected animals, mainly dogs, poses a risk to public health and might threaten the elimination goal. Additionally, newly recognised bat lyssaviruses represent a potential emerging threat as the rabies vaccine may not confer protective immunity. To support preparedness activities in EU/EEA countries, guidance for the assessment and the management of the public health risk related to rabies but also other lyssaviruses, should be developed.

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/content/10.2807/1560-7917.ES.2020.25.38.2000158
2020-09-24
2020-10-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.38.2000158
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References

  1. World Health Organization (WHO). WHO expert consultation on rabies: third report. Geneva: WHO; 2018. Available from: https://apps.who.int/iris/handle/10665/272364
  2. Fekadu M, Shaddock JH, Baer GM. Excretion of rabies virus in the saliva of dogs. J Infect Dis. 1982;145(5):715-9.  https://doi.org/10.1093/infdis/145.2.715  PMID: 7077094 
  3. Vora NM, Orciari LA, Niezgoda M, Selvaggi G, Stosor V, Lyon GM 3rd, et al. Clinical management and humoral immune responses to rabies post-exposure prophylaxis among three patients who received solid organs from a donor with rabies. Transpl Infect Dis. 2015;17(3):389-95.  https://doi.org/10.1111/tid.12393  PMID: 25851103 
  4. European Centre for Disease Prevention and Control (ECDC). The European Surveillance System (TESSy) [restricted access]. Stockholm: ECDC. [Accessed: 8 Jul 2020]. Available from: https://ecdc.europa.eu/en/publications-data/european-surveillance-system-tessy
  5. Cliquet F, Aubert M. Elimination of terrestrial rabies in Western European countries. Dev Biol (Basel). 2004;119:185-204. PMID: 15747421 
  6. Finnegan CJ, Brookes SM, Johnson N, Smith J, Mansfield KL, Keene VL, et al. Rabies in North America and Europe. J R Soc Med. 2002;95(1):9-13.  https://doi.org/10.1177/014107680209500104  PMID: 11773344 
  7. European Commission (EC). Health and consumer protection directorate general. The oral vaccination of foxes against rabies. Report of the Scientific Committee on Animal Health and Animal Welfare. Adopted on 23 October 2002. Brussels: EC; 2002. Available from: https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_scah_out80_en.pdf
  8. European Commission (EC). National Veterinary Programmes. Brussels: EC. [Accessed: 8 Jul 2020]. Available from: https://ec.europa.eu/food/funding/animal-health/national-veterinary-programmes_en
  9. World Organisation for Animal Health (OIA). Ninth meeting of the standing group of experts on lumpy skin disease (SGE LSD9), 16-17 October 2019, Athens/Greece - additional session on rabies surveillance. Paris: OIE. [Accessed: 8 Jul 2020]. Available from: https://web.oie.int/RR-Europe/eng/Regprog/en_GF_TADS%20-%20Standing%20Group%20LSD.htm#LSD9
  10. King AA, Fooks AR, Aubert M, Wandeler AI. Historical Perspective of Rabies in Europe and the Mediterranean Basin. Paris: OIE; 2004. p140-142. Available from: https://foxrabiesblueprint.org/IMG/pdf/pdf_106_king_et_al_2004.pdf
  11. Robardet E, Bosnjak D, Englund L, Demetriou P, Martín PR, Cliquet F. Zero Endemic Cases of Wildlife Rabies (Classical Rabies Virus, RABV) in the European Union by 2020: An Achievable Goal. Trop Med Infect Dis. 2019;4(4):124.  https://doi.org/10.3390/tropicalmed4040124  PMID: 31575054 
  12. World Health Organization (WHO). Rabies Bulletin Europe - Rabies Information System – queries. Geneva: WHO. [Accessed: 8 Jul 2020]. Available from: https://rbe.fli.de/site-page/queries
  13. Escobar LE, Peterson AT, Favi M, Yung V, Medina-Vogel G. Bat-borne rabies in Latin America. Rev Inst Med Trop São Paulo. 2015;57(1):63-72.  https://doi.org/10.1590/S0036-46652015000100009  PMID: 25651328 
  14. Centers for Disease Control and Prevention (CDC). Bats Lead in U.S. Rabies Risk. Atlanta: CDC. [Accessed: 21 Sep 2020]. Available from: https://www.cdc.gov/media/releases/2019/p0611-bats-rabies.html#:~:text=Bats%20are%20responsible%20for%20roughly,for%20Disease%20Control%20and%20Prevention
  15. European Food Safety Authority and European Centre for Disease Prevention and Control. The European Union One Health 2018 Zoonoses Report. EFSA Journal. 2019;17(12):5926, 276 pp. http://dx.doi.org/ https://doi.org/10.2903/j.efsa.2019.5926 
  16. Tjørnehøj K, Fooks AR, Agerholm JS, Rønsholt L. Natural and experimental infection of sheep with European bat lyssavirus type-1 of Danish bat origin. J Comp Pathol. 2006;134(2-3):190-201.  https://doi.org/10.1016/j.jcpa.2005.10.005  PMID: 16545840 
  17. Müller T, Cox J, Peter W, Schäfer R, Johnson N, McElhinney LM, et al. Spill-over of European bat lyssavirus type 1 into a stone marten (Martes foina) in Germany. J Vet Med B Infect Dis Vet Public Health. 2004;51(2):49-54.  https://doi.org/10.1111/j.1439-0450.2003.00725.x  PMID: 15030600 
  18. Dacheux L, Larrous F, Mailles A, Boisseleau D, Delmas O, Biron C, et al. European bat Lyssavirus transmission among cats, Europe. Emerg Infect Dis. 2009;15(2):280-4.  https://doi.org/10.3201/eid1502.080637  PMID: 19193273 
  19. Fooks AR, Brookes SM, Johnson N, McElhinney LM, Hutson AM. European bat lyssaviruses: an emerging zoonosis. Epidemiol Infect. 2003;131(3):1029-39.  https://doi.org/10.1017/S0950268803001481  PMID: 14959767 
  20. Echevarría JE, Banyard AC, McElhinney LM, Fooks AR. Current Rabies Vaccines Do Not Confer Protective Immunity against Divergent Lyssaviruses Circulating in Europe. Viruses. 2019;11(10):E892.  https://doi.org/10.3390/v11100892  PMID: 31554170 
  21. Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe). Caso di Lyssavirus in un gatto nel comune di Arezzo. [A case of Lyssavirus in a cat in the commune of Arezzo]. Legnaro: IZSVe; 29 Jun 2020. Italian. Available from: https://www.izsvenezie.it/caso-lyssavirus-gatto-comune-arezzo/
  22. van Thiel P-PAM, de Bie RMA, Eftimov F, Tepaske R, Zaaijer HL, van Doornum GJJ, et al. Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with coma-induction, ketamine, and antiviral drugs. PLoS Negl Trop Dis. 2009;3(7):e428.  https://doi.org/10.1371/journal.pntd.0000428  PMID: 19636367 
  23. Marano C, Moodley M, Melander E, De Moerlooze L, Nothdurft HD. Perceptions of rabies risk: a survey of travellers and travel clinics from Canada, Germany, Sweden and the UK. J Travel Med. 2019;26(Supplement_1):S3-S9. http://dx.doi.org/ https://doi.org/10.1093/jtm/tay062  PMID: 30476212
  24. De Benedictis P, Perboni G, Gentili C, Gaetti L, Zaffanella F, Mutinelli F, et al. Fatal case of human rabies imported to Italy from India highlights the importance of adequate post-exposure prophylaxis, October 2011. Euro Surveill. 2012;17(19):20168. PMID: 22607965 
  25. Gautret P, Angelo KM, Asgeirsson H, Lalloo DG, Shaw M, Schwartz E, et al. Rabies post-exposure prophylaxis started during or after travel: A GeoSentinel analysis. PLoS Negl Trop Dis. 2018;12(11):e0006951.  https://doi.org/10.1371/journal.pntd.0006951  PMID: 30422981 
  26. Johnson N, Freuling C, Horton D, Muller T, Fooks AR. Imported rabies, European Union and Switzerland, 2001-2010. Emerg Infect Dis. 2011;17(4):753-4.  https://doi.org/10.3201/eid1706.101154  PMID: 21470483 
  27. Gautret P, Parola P. Rabies vaccination for international travelers. Vaccine. 2012;30(2):126-33.  https://doi.org/10.1016/j.vaccine.2011.11.007  PMID: 22085557 
  28. World Health Organization (WHO). Rabies vaccines: WHO position paper – April 2018. Geneva: WHO; 20 Apr 2018. Available from: https://www.who.int/rabies/resources/who_wer9316/en/
  29. Hermans F. Nederlandse reiziger moet zonder inenting tegen hondsdolheid naar de tropen. [Dutch travellers must go to the tropics without vaccination against rabies]. Nijmegen: de Gelderlander; 21 Jun 2018. Dutch. Available from: https://www.gelderlander.nl/nijmegen/nederlandse-reiziger-moet-zonder-inenting-tegen-hondsdolheid-naar-de-tropen~afbe6d4b/?referrer=https://www.google.com/
  30. Folkehelseinstituttet (FHI). Slutt på utleveringsrestriksjoner for rabiesvaksine. [End of rabies vaccine delivery restrictions]. Oslo: FHI; 27 Nov 2019. Norwegian. Available from: https://www.helsebiblioteket.no/samfunnsmedisin-og-folkehelse/helseradet/_attachment/265659?_ts=16fa8a8a55d&download=true
  31. Agence nationale de sécurité du médicament et des produits de santé (ANSM). Imogam rage 150 UI/ml, solution injectable – Tensions d’approvisionnement. [Imogam rage 150 UI/ml, injectable vaccine – Supply tensions]. Saint-Denis: ANSM;8 Apr 2019. French. Available from: https://ansm.sante.fr/S-informer/Informations-de-securite-Ruptures-de-stock-des-medicaments/IMOGAM-RAGE-150-UI-ml-solution-injectable-Tensions-d-approvisionnement
  32. Institute of Tropical Medicine (ITM). Ajustement du traitement antirabique dû à une rupture de stock du vaccin. [Adjustment of the treatment against rabies due to a shortage in the vaccine stockpile]. Antwerp: ITM; 12 Jun 2019. French. Available from: https://www.itg.be/F/Article/ajustement-du-traitement-antirabique-du-a-une-rupture-de-stock-du-vaccin
  33. Mari E. Pénurie de vaccins contre la rage. [Shortage of rabies vaccines]. Paris: Le Parisien; 19 Jul 2018. French. Available from: https://www.leparisien.fr/societe/sante/penurie-de-vaccins-contre-la-rage-19-07-2018-7825983.php
  34. Taylor E, Banyard AC, Bourhy H, Cliquet F, Ertl H, Fehlner-Gardiner C, et al. Avoiding preventable deaths: The scourge of counterfeit rabies vaccines. Vaccine. 2019;37(17):2285-7.  https://doi.org/10.1016/j.vaccine.2019.03.037  PMID: 30922698 
  35. Food and Agriculture Organization of the United Nations, World Organisation for Animal Health, World Health Organization, Global Alliance for Rabies Control. Zero by 30: the global strategic plan to end human deaths from dog-mediated rabies by 2030. Geneva: WHO, 2018. Available from: https://apps.who.int/iris/bitstream/handle/10665/272756/9789241513838-eng.pdf?ua=1
  36. European Directorate for the Quality of Medicines and Healthcare. Guide to the quality and safety of organs for transplantation, 7th edition. Strasbourg: Council of Europe; 2018. Available from: https://www.edqm.eu/en/news/new-release-7th-edition-guide-quality-and-safety-organs-transplantation
  37. European Directorate for the Quality of Medicines and Healthcare. Guide to the quality and safety of tissues and cells for human application, 4th edition. Strasbourg: Council of Europe; 2018. Available from: https://www.edqm.eu/en/organs-tissues-and-cells-technical-guides
  38. Rabies confirmed in an illegally imported dog in France. Vet Rec. 2015;176(22):558.  https://doi.org/10.1136/vr.h2895  PMID: 26025705 
  39. Pérez de Diego AC, Vigo M, Monsalve J, Escudero A. The One Health approach for the management of an imported case of rabies in mainland Spain in 2013. Euro Surveill. 2015;20(6):21033.  https://doi.org/10.2807/1560-7917.ES2015.20.6.21033  PMID: 25695478 
  40. Ministère de l’Agriculture et de l’Alimentation. Cas de rage importé détecté chez un chiot ramené du Maroc sur l’île de Ré. [Imported case if rabies in a puppy from Morocco on Ré island]. Paris: Ministère de l’Agriculture et de l’Alimentation. 15 Feb 2020. French. Available from: https://agriculture.gouv.fr/telecharger/107839?token=f1fb4beb809cb0918838431f0ec1f5a1
  41. Schmiedel S, Panning M, Lohse A, Kreymann KG, Gerloff C, Burchard G, et al. Case report on fatal human rabies infection in Hamburg, Germany, March 2007. Euro Surveill. 2007;12(5):E070531 5.
  42. Rimhanen-Finne R, Järvinen A, Kuusi M, Quiambao BP, Malbas FF Jr, Huovilainen A, et al. Imported human rabies, the Philippines and Finland, 2007. Emerg Infect Dis. 2010;16(8):1318-9.  https://doi.org/10.3201/eid1608.091380  PMID: 20678336 
  43. Hunter M, Johnson N, Hedderwick S, McCaughey C, Lowry K, McConville J, et al. Immunovirological correlates in human rabies treated with therapeutic coma. J Med Virol. 2010;82(7):1255-65.  https://doi.org/10.1002/jmv.21785  PMID: 20513093 
  44. Santos A, Cale E, Dacheux L, Bourhy H, Gouveia J, Vasconcelos P. Fatal case of imported human rabies in Amadora, Portugal, August 2011. Euro Surveill. 2012;17(12):20130. PMID: 22490309 
  45. Pathak S, Horton DL, Lucas S, Brown D, Quaderi S, Polhill S, et al. Diagnosis, management and post-mortem findings of a human case of rabies imported into the United Kingdom from India: a case report. Virol J. 2014;11(1):63.  https://doi.org/10.1186/1743-422X-11-63  PMID: 24708671 
  46. Program for Monitoring Emerging Diseases (Pro-MED). Rabies – Netherlands ex Haiti, canine, human. Archive number: 2013;1791201(20130625):25. Available from: https://promedmail.org/promed-post/?id=1791201
  47. Program for Monitoring Emerging Diseases (Pro-MED). Rabies – Netherlands ex India: (Tamil Nadu) canine, human. Archive number: 2014;2721553(20140825):25. Available from: https://promedmail.org/promed-post/?id=2721553
  48. Contou D, Dacheux L, Bendib I, Jolivet S, Rodriguez C, Tomberli F, et al. Severe ketoalkalosis as initial presentation of imported human rabies in France. J Clin Microbiol. 2015;53(6):1979-82.  https://doi.org/10.1128/JCM.00219-15  PMID: 25854482 
  49. Lourido M. Muere de rabia una mujer en Madrid. [A woman in Madrid dies from rabies]. Madrid: Cadena SER; 20 Jun 2014. Spanish. Available from: https://cadenaser.com/ser/2014/06/20/sociedad/1403230405_850215.html
  50. Hommel C. Cas de rage confirmé en France au retour du Sri Lanka. [One case of rabies in France in a travellers returning from Sri Lanka]. MesVaccins.net. [Accessed: 8 Jul 2020]. French. Available from: https://www.mesvaccins.net/web/news/11418-cas-de-rage-confirme-en-france-au-retour-du-sri-lanka
  51. Program for Monitoring Emerging Diseases (Pro-MED). Rabies, human - UK: (England) ex Morocco, ex feline. Archive number: 20181113.6142425.13 Nov 2018. Available from: https://promedmail.org/promed-post/?id=6142425
  52. European Centre for Disease Prevention and Control (ECDC). Communicable Disease Threat Report, week 50, 8-14 December, Rabies imported cases - EU/EEA - 2019. Stockholm: ECDC; 13 Dec 2019. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-8-14-december-2019-week-50
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