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Association between SARS-CoV-2 infection and Kawasaki-like multisystem inflammatory syndrome: a retrospective matched case–control study, Paris, France, April to May 2020
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Julie Toubiana1,2
, Corinne Levy3,4,5,6,7 , Slimane Allali1 , Camille Jung4,5 , Marianne Leruez-Ville8 , Emmanuelle Varon4,5,6,9 , Fanny Bajolle10 , Naim Ouldali3,6,11 , Judith Chareyre12 , Stephane Béchet3 , Annie Elbez3,7 , Jean-Laurent Casanova13,14 , Martin Chalumeau1,15
, Robert Cohen3,4,6,7,16 , Jérémie F Cohen1,15
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View Affiliations Hide AffiliationsAffiliations: 1 Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France 2 Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France 3 ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France 4 Université Paris Est, IMRB-GRC GEMINI, Créteil, France 5 Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France 6 GPIP, Groupe de Pathologie Infectieuse Pédiatrique, Paris, France 7 AFPA, Association Française de Pédiatrie Ambulatoire, Saint-Germain-en-Laye, France 8 Virology laboratory, Necker-Enfants Malades University Hospital, AP-HP, EA 7328, Université de Paris, Paris, France 9 Laboratoire de Microbiologie, Centre Hospitalier Intercommunal de Créteil, Créteil, France 10 M3C-Necker-Enfants Malades University Hospital, AP-HP, Université de Paris, Paris, France 11 Unité d’épidémiologie clinique, AP-HP, Hôpital Robert Debré, ECEVE INSERM UMR 1123, Paris, France 12 Pediatric Intensive Care Unit, Necker-Enfants Malades University Hospital, AP-HP, Université de Paris, Paris, France 13 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Pediatric Hematology and Immunology Unit, Necker-Enfants Malades University Hospital, Université de Paris, Paris, France 14 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, Howard Hughes Medical Institute, New York, United States 15 Université de Paris, Centre of Research in Epidemiology and Statistics - CRESS, INSERM, F-75004 Paris, France 16 Unité Court Séjour, Petits nourrissons, Service de Néonatalogie, Centre Hospitalier Intercommunal de Créteil, Créteil, FranceMartin Chalumeaumartin.chalumeau inserm.fr
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Citation style for this article: Toubiana Julie, Levy Corinne, Allali Slimane, Jung Camille, Leruez-Ville Marianne, Varon Emmanuelle, Bajolle Fanny, Ouldali Naim, Chareyre Judith, Béchet Stephane, Elbez Annie, Casanova Jean-Laurent, Chalumeau Martin, Cohen Robert, Cohen Jérémie F. Association between SARS-CoV-2 infection and Kawasaki-like multisystem inflammatory syndrome: a retrospective matched case–control study, Paris, France, April to May 2020. Euro Surveill. 2020;25(48):pii=2001813. https://doi.org/10.2807/1560-7917.ES.2020.25.48.2001813 Received: 18 Oct 2020; Accepted: 03 Dec 2020
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Abstract
We assessed the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Kawasaki disease (KD)-like multisystem inflammatory syndrome in a retrospective case–control study in France. RT-PCR and serological tests revealed SARS-CoV-2 infection in 17/23 cases vs 11/102 controls (matched odds ratio: 26.4; 95% confidence interval: 6.0–116.9), indicating strong association between SARS-CoV-2 infection and KD-like illness. Clinicians should keep a high level of suspicion for KD-like illness during the COVID-19 pandemic.

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