1887
Rapid communication Open Access
Like 0

Abstract

In Tuscany, Italy, New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE) have increased since November 2018. Between November 2018 and October 2019, 1,645 samples were NDM-CRE-positive: 1,270 (77.2%) cases of intestinal carriage, 129 (7.8%) bloodstream infections and 246 (14.9%) infections/colonisations at other sites. were prevalent (1,495; 90.9%), with ST147/NDM-1 the dominant clone. Delayed outbreak identification and response resulted in sustained NDM-CRE transmission in the North-West area of Tuscany, but successfully contained spread within the region.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.6.2000085
2020-02-13
2020-02-17
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.6.2000085
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/6/eurosurv-25-6-3.html?itemId=/content/10.2807/1560-7917.ES.2020.25.6.2000085&mimeType=html&fmt=ahah

References

  1. European Centre for Disease Prevention and Control (ECDC). Regional outbreak of New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacteriaceae, Italy, 2018-2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/04-Jun-2019-RRA-Carbapenems%2C%20Enterobacteriaceae-Italy.pdf
  2. Regione Toscana. Decreto nr.12772 del 26.07.2019 “Indicazioni regionali per il contrasto alla diffusione di Enterobacterales produttori di metallo-beta lattamasi di tipo New-Delhi.[Decree no. 12772 of 26 July 2019. Regional indications for the fight against the spread of Enterobacterales producing metallo-beta-lactamases of the New-Delhi type]. Florence: Regione Toscana; 2019. Italian. Available from: http://www301.regione.toscana.it/bancadati/atti/Contenuto.xml?id=5225137&nomeFile=Decreto_n.12772_del_26-07-2019
  3. Avgoulea K, Di Pilato V, Zarkotou O, Sennati S, Politi L, Cannatelli A, et al. Characterization of extensively drug-resistant or pandrug-resistant sequence type 147 and 101 OXA-48-producing Klebsiella pneumoniae causing bloodstream infections in patients in an intensive care unit. Antimicrob Agents Chemother. 2018;62(7):e02457-17.  https://doi.org/10.1128/AAC.02457-17  PMID: 29661874 
  4. Wu W, Feng Y, Tang G, Qiao F, McNally A, Zong Z. NDM metallo-β-lactamases and their bacterial producers in health care settings. Clin Microbiol Rev. 2019;32(2):e00115-18.  https://doi.org/10.1128/CMR.00115-18  PMID: 30700432 
  5. Albiger B, Glasner C, Struelens MJ, Grundmann H, Monnet DLEuropean Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working group. Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015. Euro Surveill. 2015;20(45):30062.  https://doi.org/10.2807/1560-7917.ES.2015.20.45.30062  PMID: 26675038 
  6. Baraniak A, Machulska M, Żabicka D, Literacka E, Izdebski R, Urbanowicz P, et al. Towards endemicity: large-scale expansion of the NDM-1-producing Klebsiella pneumoniae ST11 lineage in Poland, 2015-16. J Antimicrob Chemother. 2019;74(11):3199-204.  https://doi.org/10.1093/jac/dkz315  PMID: 31406993 
  7. Politi L, Gartzonika K, Spanakis N, Zarkotou O, Poulou A, Skoura L, et al. Emergence of NDM-1-producing Klebsiella pneumoniae in Greece: evidence of a widespread clonal outbreak. J Antimicrob Chemother. 2019;74(8):2197-202.  https://doi.org/10.1093/jac/dkz176  PMID: 31065697 
  8. Bellino S, D’Ancona FP, Iacchini S, Monaco M, Pantosti A, Pezzotti PAR-ISS. Sorveglianza nazionale dell’Antibiotico-Resistenza I dati 2018. [National surveillance of antibiotic resistance - 2018 data]. Rome: Istituto Superiore di Sanità; 2019. Italian. Available from: https://www.epicentro.iss.it/antibiotico-resistenza/ar-iss/rapporto-1-dati-2018.pdf
  9. Gaibani P, Ambretti S, Berlingeri A, Cordovana M, Farruggia P, Panico M, et al. Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro Surveill. 2011;16(47):20027.  https://doi.org/10.2807/ese.16.47.20027-en  PMID: 22152705 
  10. D’Andrea MM, Venturelli C, Giani T, Arena F, Conte V, Bresciani P, et al. Persistent carriage and infection by multidrug-resistant Escherichia coli ST405 producing NDM-1 carbapenemase: report on the first Italian cases. J Clin Microbiol. 2011;49(7):2755-8.  https://doi.org/10.1128/JCM.00016-11  PMID: 21525229 
  11. David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, et al. Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol. 2019;4(11):1919-29.  https://doi.org/10.1038/s41564-019-0492-8  PMID: 31358985 
  12. Donker T, Wallinga J, Slack R, Grundmann H. Hospital networks and the dispersal of hospital-acquired pathogens by patient transfer. PLoS One. 2012;7(4):e35002.  https://doi.org/10.1371/journal.pone.0035002  PMID: 22558106 
  13. Andrianou X, Donker T, Pezzotti P, Iannazzo S, Righi L, Forni S, et al. Outbreak of carbapenem-resistant Klebsiella pneumoniae in Italy, 2018-2019: the role of patient transfers between hospitals in facilitating transmission. European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), Stockholm, 27-29 Nov 2019.
  14. Forni S, D’Arienzo S, Gemmi F, Arena F, Bachini L, Barnini S, et al. L’antibiotico-resistenza e L’uso di antibiotici in Toscana. [Antibiotic resistance and the use of antibiotics in Tuscany]. Florence: Agenzia Regionale Sanità della Toscana; 2019. Italian. Available from: https://www.ars.toscana.it/images/pubblicazioni/Collana_ARS/2019/MB_2019_doc_103_rev_18_giu.pdf
/content/10.2807/1560-7917.ES.2020.25.6.2000085
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error