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Abstract

Cases of West Nile neuroinvasive disease (WNND) in Spain increased in summer 2020. Here we report on this increase and the local, regional and national public health measures taken in response. We analysed data from regional surveillance networks and the National Epidemiological Surveillance Network, both for human and animal West Nile virus (WNV) infection. During the 2020 season, a total of 77 human cases of WNV infection (median age 65 years; 60% males) were detected in the south-west of Spain; 72 (94%) of these cases developed WNND, presenting as meningoencephalitis, seven of which were fatal. In the previous two decades, only six human cases of WNND were detected in Spain. Reduced activities for vector control this season, together with other factors, might have contributed to the massive increase. Public health measures including vector control, campaigns to raise awareness among physicians and the general population, and interventions to ensure the safety of donations of blood products, organs, cells and tissues were effective to reduce transmission. Going forward, maintenance of vector control activities and an update of the vector-borne diseases response plan in Spain is needed.

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/content/10.2807/1560-7917.ES.2021.26.19.2002010
2021-05-13
2021-09-28
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.19.2002010
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References

  1. Patel H, Sander B, Nelder MP. Long-term sequelae of West Nile virus-related illness: a systematic review. Lancet Infect Dis. 2015;15(8):951-9.
  2. Petersen LR, Brault AC, Nasci RS. West Nile Virus: Review of the Literature. JAMA. 2013;310(3):308-15.
  3. Bakonyi T, Ferenczi E, Erdélyi K, Kutasi O, Csörgő T, Seidel B, et al. Explosive spread of a neuroinvasive lineage 2 West Nile virus in Central Europe, 2008/2009. Vet Microbiol. 2013;165(1-2):61-70.
  4. Papa A, Bakonyi T, Xanthopoulou K, Vázquez A, Tenorio A, Nowotny N. Genetic characterization of West Nile virus lineage 2, Greece, 2010. Emerg Infect Dis. 2011;17(5):920-2.
  5. Chancey C, Grinev A, Volkova E, Rios M. The Global Ecology and Epidemiology of West Nile Virus. BioMed Res Int. 2015;2015:376230.
  6. European Centre for Disease Prevention and Control (ECDC) and European Food Safety Authority. (EFSA). The European Union One Health 2019 Zoonoses Report. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/zoonoses-EU-one-health-2019-report.pdf
  7. European Centre for Disease Prevention and Control (ECDC). Epidemiological update: West Nile virus transmission season in Europe, 2020. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/en/news-events/epidemiological-update-west-nile-virus-transmission-season-europe-2020
  8. Lozano A, Filipe AR. Anticuerpos frente a virus West Nile y otros virus transmitidos por artropodos en la poblacion del Delta Del Ebro. Rev Esp Salud Publica. 1998;72(3):245-50.  https://doi.org/10.1590/S1135-57271998000300009  PMID: 9810831 
  9. Kaptoul D, Viladrich PF, Domingo C, Niubó J, Martínez-Yélamos S, De Ory F, et al. West Nile virus in Spain: report of the first diagnosed case (in Spain) in a human with aseptic meningitis. Scand J Infect Dis. 2007;39(1):70-1.  https://doi.org/10.1080/00365540600740553 
  10. Busquets N, Laranjo-González M, Soler M, Nicolás O, Rivas R, Talavera S, et al. Detection of West Nile virus lineage 2 in North-Eastern Spain (Catalonia). Transbound Emerg Dis. 2019;66(2):617-21.
  11. Vazquez A, Sanchez-Seco MP, Ruiz S, Molero F, Hernandez L, Moreno J, et al. Putative new lineage of west nile virus, Spain. Emerg Infect Dis. 2010;16(3):549-52.
  12. Instituto de Salud Carlos III (ISCIII). Fiebre del Nilo occidental. [West Nile Virus]. Madrid: ISCIII. [Accessed: 10 May 2021]. Spanish. Available from: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Documents/PROTOCOLOS/Protocolo%20vigilancia%20fiebre%20Nilo%20occidental_RENAVE.pdf
  13. European Commission. Commission implementing decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 6.7.2018: L170/1. Available from: https://eur-lex.europa.eu/eli/dec_impl/2018/945/oj
  14. Vázquez A, Herrero L, Negredo A, Hernández L, Sánchez-Seco M, Tenorio A. Real time PCR assay for detection of all known lineages of West Nile virus. J Virol Methods. 2016;236:266-70.
  15. Sánchez-Seco M, Rosario D, Domingo C, Hernández LKV, Guzmán M, Tonorio A, et al. Generic RT-nested-PCR for detection of flaviviruses using degenerated primers and internal control followed by sequencing for specific identification. J Virol Methods. 2005;126(1-2):101-9.
  16. Vázquez A, Sánchez-Seco M, Palacios G, Molero F, Reyes N. Novel flaviviruses detected in different species of mosquitoes in Spain. Vector Borne Zoonotic Dis. 2012;12(3):223-9.
  17. Ministry of Agriculture. Plan de vigilancia de la encefalitis del Oeste del Nilo (West Nile) en España. [Surveillance plan for West Nile encephalitis in Spain]. Madrid: Ministry of Agriculture, Fisheries and Food; 2012. Spanish.
  18. Ministry of Agriculture. Fisheries and Food. Programa de Vigilancia de fiebre del Nilo occidental 2021. [West Nile Fever Surveillance Program 2021]. Madrid: Ministry of Agriculture, Fisheries and Food; 2020. Spanish. Available from: https://www.mapa.gob.es/es/ganaderia/temas/sanidad-animal-higiene-ganadera/programafiebredelnilooccidental2021_tcm30-437515.pdf
  19. European Centre for Disease Prevention and Control (ECDC). Operational tool on rapid risk assessment methodology - ECDC 2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/en/publications-data/operational-tool-rapid-risk-assessment-methodology-ecdc-2019
  20. European Commission. Regulation (EC) No 1059/2003 of the European Parliament and of the Council of 26 May 2003 on the establishment of a common classification of territorial units for statistics (NUTS). Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 21.06.2003:L 155. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex%3A32003R1059
  21. Ministry of Agriculture. Fisheries and Food. Actualización de la situación epidemiológica de la fiebre del Nilo occidental (West Nile fever). [Update on the epidemiological situation of West Nile Virus]. Madrid: Ministry of Agriculture, Fisheries and Food; 29 Jan 2021. Spanish. Available from: https://www.mapa.gob.es/es/ganaderia/temas/sanidad-animal-higiene-ganadera/informefno_2021-01-29_tcm30-435293.pdf
  22. Doñana Biological Reserve (EBD). Clima y Meteorología. [Climate and meteorology]. Huelva: EBD. [Accessed: 5 Apr 2021]. Spanish. Available from: http://icts.ebd.csic.es/es/datos-meteorologicos
  23. Spanish Ministry of Health. Meningoencefalitis por el virus del Nilo occidental en España (2a actualización-cierre de temporada). [West Nile Meningoencephalitis in Spain (2nd update – en of season]. Madrid: Ministry of Health; 3 Dec 2020. Spanish. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/docs/20201203_ERR_Nilo_Occidental.pdf
  24. Scientific Committee for Transfusion Safety. Virus del Nilo Occidental. [West Nile Virus]. Madrid: Ministry of Health. [Accessed: 7 May 2021]. Spanish. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/medicinaTransfusional/acuerdos/docs/Virus_Nilo_Occidental.pdf
  25. Organización Nacional de Trasplantes (ONT). [National Transplant Organisation]. Documento de Consenso del Grupo de Estudio de la Infección en el Trasplante (GESITRA) perteneciente a la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) y la Organización Nacional de Trasplantes (ONT) sobre los Criterios de Selección del Donante de Órganos Sólidos en Relación a las Enfermedades Infecciosas.[ Consensus Document of the Transplant Infection Study Group (GESITRA) belonging to the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the National Transplant Organization (ONT) on the Selection Criteria for Solid Organ Donors in Relationship to Infectious Diseases]. Madrid: ONT; 2019. Spanish. Available from: http://www.ont.es/infesp/DocumentosDeConsenso/GESITRA_ONT_SEIMC_WEB_mayo2020.pdf
  26. Sotelo E, Fernández-Pinero J, Llorente F, Vázquez A, Moreno A, Agüero M, et al. Phylogenetic relationships of Western Mediterranean West Nile virus strains (1996-2010) using full-length genome sequences: single or multiple introductions. J Gen Virol. 2011;92(11):2512-22.
  27. McGill F, Griffiths MJ, Bonnett LJ, Geretti AM, Michael BD, Beeching NJ, et al. Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. Lancet Infect Dis. 2018;18(9):992-1003.
  28. Gibbons CL, Mangen M-JJ, Plass D, Havelaar AH, Brooke RJ, Kramarz P, et al. Measuring underreporting and under-ascertainment in infectious disease datasets: a comparison of methods. BMC Public Health. 2014;14(1):1-17.
  29. Vázquez A, Ruiz S, Herrero L, Moreno J, Molero F, Magallanes A, et al. West Nile and Usutu viruses in mosquitoes in Spain, 2008-2009. Am J Trop Med Hyg. 2011;85(1):178-81.
  30. Busquets N, Alba A, Allepuz A, Aranda C, Nuñez JI. Usutu Virus Sequences in Culex pipiens (Diptera: Culicidae), Spain. Emerg Infect Dis. 2008;14(5):861-3.
  31. Höfle U, Gamino V, de Mera I, Mangold A, Ortíz J, de la Fuente J. Usutu virus in migratory song thrushes, Spain. Emerg Infect Dis. 2013;19(7):1173-5.
  32. Llorente F, Pérez-Ramírez E, Fernández-Pinero J, Soriguer R, Figuerola J, Jiménez-Clavero . Flaviviruses in Game Birds, Southern Spain, 2011-2012. Emerg Infect Dis. 2013;19(6):1023-5.
  33. Bravo-Barriga D, Aguilera-Sepúlveda P, Guerrero-Carvajal F, Llorente F, Reina D, Pérez-Martín JE, et al. West Nile and Usutu virus infections in wild birds admitted to rehabilitation centres in Extremadura, western Spain, 2017-2019. Vet Microbiol. 2021;255:109020.
  34. Vanhomwegen J, Beck C, Desprès P, Figuerola A, García R. Circulation of Zoonotic Arboviruses in Equine Populations of Mallorca Island (Spain). Vector Borne Zoonotic Dis. 2017;17(5):340-6.
  35. Caballero-Gómez J, Cano-Terriza D, Lecollinet S, Carbonell M, Martínez-Valverde R. Evidence of exposure to zoonotic flaviviruses in zoo mammals in Spain and their potential role as sentinel species. Vet Microbiol. 2020;247:108763.
  36. Grottola A, Marcacci M, Tagliazucchi S, Gennari W, Di Gennaro A, Orsini M, et al. Usutu virus infections in humans: a retrospective analysis in the municipality of Modena, Italy. Clin Microbiol Infect. 2017;23(1):33-7.
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