1887
Rapid communication Open Access
Like 0

Abstract

A breakthrough infection occurred in a fully Comirnaty (BNT162b2) vaccinated healthcare worker with high levels of neutralising antibodies with the SARS-CoV-2 B.1.351 (Beta) variant in February 2021. The infection was subsequently transmitted to their unvaccinated spouse. Sequencing revealed an identical virus in both spouses, with a match of all nine single nucleotide polymorphisms typical for B.1.351. To the best of our knowledge, no transmission of any variant of SARS-CoV-2 from a fully vaccinated person has been described before.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2021.26.30.2100673
2021-07-29
2021-09-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.30.2100673
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/26/30/eurosurv-26-30-2.html?itemId=/content/10.2807/1560-7917.ES.2021.26.30.2100673&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO). Tracking SARS-CoV-2 variants. Geneva: WHO. [Accessed: 25 Jul 2021]. Available from: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants.
  2. Tegally H, Wilkinson E, Lessells RJ, Giandhari J, Pillay S, Msomi N, et al. Sixteen novel lineages of SARS-CoV-2 in South Africa. Nat Med. 2021;27(3):440-6.  https://doi.org/10.1038/s41591-021-01255-3  PMID: 33531709 
  3. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-15.  https://doi.org/10.1056/NEJMoa2034577  PMID: 33301246 
  4. Eberle U, Heinzinger S, Konrad R, Wimmer C, Liebl B, Katz K, et al. Virological COVID-19 surveillance in Bavaria, Germany suggests no SARS-CoV-2 spread prior to the first German case in January 2020. Infection. 2021.  https://doi.org/10.1007/s15010-021-01611-y  PMID: 33891281 
  5. Quick J. nCoV-2019 sequencing protocol V.1. Berkeley: protocols.io. 22 Jan 2020. Available from: https://www.protocols.io/view/ncov-2019-sequencing-protocol-bbmuik6w?version_warning=no&step=1
  6. Li H, Durbin R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics. 2010;26(5):589-95.  https://doi.org/10.1093/bioinformatics/btp698  PMID: 20080505 
  7. Grubaugh ND, Gangavarapu K, Quick J, Matteson NL, De Jesus JG, Main BJ, et al. An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar. Genome Biol. 2019;20(1):8.  https://doi.org/10.1186/s13059-018-1618-7  PMID: 30621750 
  8. pangolin: lineage assignment in an emerging pandemic as an epidemiological tool. San Francisco: GitHub. [Accessed: 20 Jul 2021]. Available from: https://github.com/cov-lineages/pangolin
  9. Rambaut A, Holmes EC, O’Toole Á, Hill V, McCrone JT, Ruis C, et al. A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology. Nat Microbiol. 2020;5(11):1403-7.  https://doi.org/10.1038/s41564-020-0770-5  PMID: 32669681 
  10. Haselmann V, Özçürümez MK, Klawonn F, Ast V, Gerhards C, Eichner R, et al. Results of the first pilot external quality assessment (EQA) scheme for anti-SARS-CoV2-antibody testing. Clin Chem Lab Med. 2020;58(12):2121-30.  https://doi.org/10.1515/cclm-2020-1183  PMID: 32853163 
  11. Haas EJ, Angulo FJ, McLaughlin JM, Anis E, Singer SR, Khan F, et al. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet. 2021;397(10287):1819-29.  https://doi.org/10.1016/S0140-6736(21)00947-8  PMID: 33964222 
  12. Dagan N, Barda N, Kepten E, Miron O, Perchik S, Katz MA, et al. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med. 2021;384(15):1412-23.  https://doi.org/10.1056/NEJMoa2101765  PMID: 33626250 
  13. Harris RJ, Hall JA, Zaidi A, Andrews NJ, Dunbar JK, Dabrera G. Effect of Vaccination on Household Transmission of SARS-CoV-2 in England. N Engl J Med. 2021;NEJMc2107717.  https://doi.org/10.1056/NEJMc2107717  PMID:34161702
  14. Vetter P, Cordey S, Schibler M, Vieux L, Despres L, Laubscher F, et al. Clinical, virologic and immunologic features of a mild case of SARS-CoV-2 reinfection. Clin Microbiol Infect. 2021;S1198-743X(21)00085-9. PMID:33618012
  15. Mahase E. Covid-19: Longer interval between Pfizer doses results in higher antibody levels, research finds. BMJ. 2021;374:n1875.  https://doi.org/10.1136/bmj.n1875  PMID: 34301631 
  16. Robert Koch Institute (RKI). Mitteilung der STIKO zur COVID-19-Impfung: Impfabstand und heterologes Impfschema nach Erstimpfung mit Vaxzevria (1.7.2021). [STIKO announcement on COVID-19 vaccination: Vaccination interval and heterologous vaccination schedule after first vaccination dose with Vaxzevria (1.7.2021)]. Berlin: RKI; 1 Jul 2021. German. Available from: https://www.rki.de/DE/Content/Kommissionen/STIKO/Empfehlungen/PM_2021-07-01.html
/content/10.2807/1560-7917.ES.2021.26.30.2100673
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error