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Abstract

Background

Seasonal influenza-like illness (ILI) affects millions of people yearly. Severe acute respiratory infections (SARI), mainly influenza, are a leading cause of hospitalisation and mortality. Increasing evidence indicates that non-influenza respiratory viruses (NIRV) also contribute to the burden of SARI. In Belgium, SARI surveillance by a network of sentinel hospitals has been ongoing since 2011.

Aim

We report the results of using in-house multiplex qPCR for the detection of a flexible panel of viruses in respiratory ILI and SARI samples and the estimated incidence rates of SARI associated with each virus.

Methods

We defined ILI as an illness with onset of fever and cough or dyspnoea. SARI was defined as an illness requiring hospitalisation with onset of fever and cough or dyspnoea within the previous 10 days. Samples were collected in four winter seasons and tested by multiplex qPCR for influenza virus and NIRV. Using catchment population estimates, we calculated incidence rates of SARI associated with each virus.

Results

One third of the SARI cases were positive for NIRV, reaching 49.4% among children younger than 15 years. In children younger than 5 years, incidence rates of NIRV-associated SARI were twice that of influenza (103.5 vs 57.6/100,000 person-months); co-infections with several NIRV, respiratory syncytial viruses, human metapneumoviruses and picornaviruses contributed most (33.1, 13.6, 15.8 and 18.2/100,000 person-months, respectively).

Conclusion

Early testing for NIRV could be beneficial to clinical management of SARI patients, especially in children younger than 5 years, for whom the burden of NIRV-associated disease exceeds that of influenza.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2021-09-23
2024-04-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.38.2001104
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Spotlight influenza: Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, Belgium, 2015 to 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Lorenzo+Subissi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Subissi Lorenzo</a>, <a href="/search?value1=Nathalie+Bossuyt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bossuyt Nathalie</a>, <a href="/search?value1=Marijke+Reynders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynders Marijke</a>, <a href="/search?value1=Mich%C3%A8le+G%C3%A9rard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gérard Michèle</a>, <a href="/search?value1=Nicolas+Dauby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dauby Nicolas</a>, <a href="/search?value1=Patrick+Lacor&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lacor Patrick</a>, <a href="/search?value1=Siel+Daelemans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Daelemans Siel</a>, <a href="/search?value1=B%C3%A9n%C3%A9dicte+Lissoir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lissoir Bénédicte</a>, <a href="/search?value1=Xavier+Holemans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Holemans Xavier</a>, <a href="/search?value1=Koen+Magerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Magerman Koen</a>, <a href="/search?value1=Door+Jouck&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jouck Door</a>, <a href="/search?value1=Marc+Bourgeois&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bourgeois Marc</a>, <a href="/search?value1=B%C3%A9n%C3%A9dicte+Delaere&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delaere Bénédicte</a>, <a href="/search?value1=Sophie+Quoilin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quoilin Sophie</a>, <a href="/search?value1=Steven+Van+Gucht&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Gucht Steven</a>, <a href="/search?value1=Isabelle+Thomas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thomas Isabelle</a>, <a href="/search?value1=Cyril+Barbezange&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbezange Cyril</a></span>. Spotlight influenza: Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, Belgium, 2015 to 2019. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(38):pii=2001104. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.38.2001104" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.38.2001104</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Jun 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 20 Apr 2021 </span> </p>
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