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Abstract

Background

Despite the availability of highly effective direct-acting antivirals (DAAs) and the expected treatment as prevention (TasP) effect, transmission of hepatitis C virus (HCV) persists in men who have sex with men (MSM) who engage in high-risk sexual behaviours.

Aim

We aimed to estimate the incidence of primary HCV infection among MSM living with HIV in France when DAA was readily available.

Methods

We used data from a large French hospital cohort of persons living with HIV (ANRS CO4-FHDH) prospectively collected between 2014 and 2017. HCV incidence rates were calculated using person-time methods for HCV-negative MSM at inclusion who had serological follow-up from 1 January 2014 to 31 December 2017. Sensitivity analyses were performed by varying the main assumptions to assess their impact on the results.

Results

Of 14,273 MSM living with HIV who were initially HCV-seronegative, 330 acquired HCV during follow-up over 45,866 person-years (py), resulting in an overall estimated incidence rate of 0.72/100 py (95% CI: 0.65–0.80). HCV incidence significantly decreased from 0.98/100 py (95% CI: 0.81–1.19) in 2014 to 0.45/100 py (95% CI: 0.35–0.59) in 2017 (54% decrease; 95% CI: 36–67). This trend was confirmed by most of the sensitivity analyses.

Conclusion

The primary incidence of HCV was halved for MSM living with HIV between 2014 and 2017. This decrease may be related to unrestricted DAA availability in France for individuals living with HIV. Further interventions, including risk reduction, are needed to reach HCV micro-elimination in MSM living with HIV.

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2021-09-23
2024-04-25
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.38.2001321
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Hepatitis C virus (HCV) incidence among men who have sex with men (MSM) living with HIV: results from the French Hospital Database on HIV (ANRS CO4-FHDH) cohort study, 2014 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Mathieu+Castry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Castry Mathieu</a>, <a href="/search?value1=Anthony+Cousien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cousien Anthony</a>, <a href="/search?value1=Jonathan+Bellet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bellet Jonathan</a>, <a href="/search?value1=Karen+Champenois&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Champenois Karen</a>, <a href="/search?value1=Gilles+Pialoux&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pialoux Gilles</a>, <a href="/search?value1=Yazdan+Yazdanpanah&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yazdanpanah Yazdan</a>, <a href="/search?value1=Dominique+Costagliola&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Costagliola Dominique</a>, <a href="/search?value1=Sophie+Grabar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grabar Sophie</a>, <a href="/search?value1=Sylvie+Deuffic-Burban&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deuffic-Burban Sylvie</a>, <a href="/search?value1=on+behalf+of+the+French+Hospital+Database+on+HIV+%28ANRS+CO4-FHDH+Cohort%29&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the French Hospital Database on HIV (ANRS CO4-FHDH Cohort)</a></span>. Hepatitis C virus (HCV) incidence among men who have sex with men (MSM) living with HIV: results from the French Hospital Database on HIV (ANRS CO4-FHDH) cohort study, 2014 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(38):pii=2001321. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.38.2001321" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.38.2001321</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 01 Jul 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 26 Feb 2021 </span> </p>
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