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Abstract

Europe has experienced a large COVID-19 wave caused by the Delta variant in winter 2021/22. Using mathematical models applied to Metropolitan France, we find that boosters administered to ≥ 65, ≥ 50 or ≥ 18 year-olds may reduce the hospitalisation peak by 25%, 36% and 43% respectively, with a delay of 5 months between second and third dose. A 10% reduction in transmission rates might further reduce it by 41%, indicating that even small increases in protective behaviours may be critical to mitigate the wave.

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/content/10.2807/1560-7917.ES.2022.27.1.2101125
2022-01-06
2024-10-04
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.1.2101125
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Impact of booster vaccination on the control of COVID-19 Delta wave in the context of waning immunity: application to France in the winter 2021/22
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Paolo+Bosetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bosetti Paolo</a>, <a href="/search?value1=C%C3%A9cile+Tran+Kiem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tran Kiem Cécile</a>, <a href="/search?value1=Alessio+Andronico&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andronico Alessio</a>, <a href="/search?value1=Juliette+Paireau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paireau Juliette</a>, <a href="/search?value1=Daniel+Levy-Bruhl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Levy-Bruhl Daniel</a>, <a href="/search?value1=Lise+Alter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alter Lise</a>, <a href="/search?value1=Arnaud+Fontanet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fontanet Arnaud</a>, <a href="/search?value1=Simon+Cauchemez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cauchemez Simon</a></span>. Impact of booster vaccination on the control of COVID-19 Delta wave in the context of waning immunity: application to France in the winter 2021/22. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(1):pii=2101125. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.1.2101125" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.1.2101125</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Dec 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Dec 2021 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.1.2101125
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