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An increase of acute hepatitis of unknown aetiology has been reported among children in multiple countries worldwide. With a rapid online survey among hospitals in and outside of Europe, we describe case numbers recorded from 1 January to 18 April 2022 vs the previous 5 years. Of 24 countries that responded, we identified 5/17 European and 1/7 non-European countries with an elevation in probable cases of unexplained acute hepatitis, and severe cases were elevated in five European countries.


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  1. World Health Organization (WHO). Multi-Country – Acute, severe hepatitis of unknown origin in children. Geneva: WHO. [Accessed: 25 Apr 2022]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/multi-country-acute-severe-hepatitis-of-unknown-origin-in-children
  2. Marsh K, Tayler R, Pollock L, Roy K, Lakha F, Ho A, et al. Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022. Euro Surveill. 2022;27(15):2200318.  https://doi.org/10.2807/1560-7917.ES.2022.27.15.2200318  PMID: 35426362 
  3. United Kingdom Health Security Agency (UKHSA). Increase in hepatitis (liver inflammation) cases in children under investigation. London: UKHSA. [Accessed: 7 May 2022]. Available at: https://www.gov.uk/government/news/increase-in-hepatitis-liver-inflammation-cases-in-children-under-investigation
  4. European Centre for Disease Prevention and Control (ECDC). Increase in severe acute hepatitis cases of unknown aetiology in children – 28 April 2022. Stockholm: ECDC; 2022. Available from: https://www.ecdc.europa.eu/en/publications-data/increase-severe-acute-hepatitis-cases-unknown-aetiology-children
  5. United Kingdom Health Security Agency (UKHSA). Investigation into acute hepatitis of unknown aetiology in children in England, technical briefing 2. London: UKHSA. [Accessed: 9 May 2022]. Available at: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1073704/acute-hepatitis-technical-briefing-2.pdf
  6. United Kingdom Health Security Agency (UKHSA). Increase in acute hepatitis cases of unknown aetiology in children. London: UKHSA. [Accessed: 17 Apr 2022]. Available at: https://www.gov.uk/government/publications/hepatitis-increase-in-acute-cases-of-unknown-aetiology-in-children/increase-in-acute-hepatitis-cases-of-unknown-aetiology-in-children

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