Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022

Ruben H de Kleine; Willem S Lexmond; Gustav Buescher; Ekkehard Sturm; Deidre Kelly; Ansgar W Lohse; Dominic Lenz; Marianne Hørby Jørgensen; on behalf of the contributors to the survey

doi:10.2807/1560-7917.ES.2022.27.19.2200369

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Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022
Ruben H de Kleine^1,2 , Willem S Lexmond^2,3 , Gustav Buescher^2,4 , Ekkehard Sturm^2,5 , Deidre Kelly^2,6 , Ansgar W Lohse^2,4 , Dominic Lenz^2,7,* , Marianne Hørby Jørgensen^2,8,* , on behalf of the contributors to the survey⁹
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Affiliations: ¹ Department of Surgery, Division of Hepatobiliairy Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands ² European Reference Network for hepatological diseases (ERN RARE-LIVER) ³ Department of Paediatrics, Division of Gastroenterology and Hepatology, Beatrix Children’s Hospital, University of Groningen, Groningen, The Netherlands ⁴ Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany ⁵ Paediatric Gastroenterology/ Hepatology, University Hospital Tuebingen, Tuebingen, Germany ⁶ University of Birmingham, and The Liver Unit, Birmingham Women & Children’s Hospital, Birmingham, UK ⁷ Division of Neuropaediatrics and Paediatric Metabolic Medicine, Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany ⁸ Department of Paediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark ⁹ The contributors to the survey are acknowledged at the end of the article

* These authors contributed equally to this work and share last authorship.
Correspondence:
Ruben de Kleine
R.de.kleine umcg.nl
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Citation style for this article: de Kleine Ruben H, Lexmond Willem S, Buescher Gustav, Sturm Ekkehard, Kelly Deidre, Lohse Ansgar W, Lenz Dominic, Hørby Jørgensen Marianne, on behalf of the contributors to the survey. Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022. Euro Surveill. 2022;27(19):pii=2200369. https://doi.org/10.2807/1560-7917.ES.2022.27.19.2200369 Received: 29 Apr 2022; Accepted: 12 May 2022

Abstract

To detect potential concern about severe acute hepatitis in children, we conducted a survey among 50 ERN RARE-LIVER centres. By 26 April 2022, 34 centres, including 25 transplant centres, reported an estimated median of 3–5, 0–2 and 3–5 cases in 2021, 2020 and 2019 and a mean of 2 (range: 0–8) cases between January and April 2022 (mean in 10 large liver transplant centres: 3). Twelve centres reported suspicion of an increase, but no rise.

This work is licensed under a Creative Commons Attribution 4.0 International License.

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2022-05-12

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Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022

Citation style for this article: <a href="/search?value1=Ruben+H+de+Kleine&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Kleine Ruben H</a>, <a href="/search?value1=Willem+S+Lexmond&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lexmond Willem S</a>, <a href="/search?value1=Gustav+Buescher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buescher Gustav</a>, <a href="/search?value1=Ekkehard+Sturm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sturm Ekkehard</a>, <a href="/search?value1=Deidre+Kelly&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kelly Deidre</a>, <a href="/search?value1=Ansgar+W+Lohse&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lohse Ansgar W</a>, <a href="/search?value1=Dominic+Lenz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lenz Dominic</a>, <a href="/search?value1=Marianne+H%C3%B8rby+J%C3%B8rgensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hørby Jørgensen Marianne</a>, <a href="/search?value1=on+behalf+of+the+contributors+to+the+survey&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the contributors to the survey</a>. Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(19):pii=2200369. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.19.2200369" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.19.2200369</a> Received: 29 Apr 2022;   Accepted: 12 May 2022

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Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022

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