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Abstract

We report a ceftriaxone-resistant, multidrug-resistant urogenital in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG-STAR ST4859) and mosaic . The latter, causing ceftriaxone resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial-susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftriaxone resistance.

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/content/10.2807/1560-7917.ES.2023.28.10.2300125
2023-03-09
2024-04-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.10.2300125
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Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Daniel+Golparian&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Golparian Daniel</a>, <a href="/search?value1=Nora+Vestberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vestberg Nora</a>, <a href="/search?value1=Wiktor+S%C3%B6dersten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Södersten Wiktor</a>, <a href="/search?value1=Susanne+Jacobsson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jacobsson Susanne</a>, <a href="/search?value1=Makoto+Ohnishi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ohnishi Makoto</a>, <a href="/search?value1=Hong+Fang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fang Hong</a>, <a href="/search?value1=Karin+Haij+Bhattarai&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bhattarai Karin Haij</a>, <a href="/search?value1=Magnus+Unemo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Unemo Magnus</a></span>. Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(10):pii=2300125. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.10.2300125" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.10.2300125</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Feb 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 Mar 2023 </span> </p>
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