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Abstract

Introduction

Two large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021.

Aim

We aimed to measure VE against PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients ≥ 20 years, combining data from these networks during Alpha (March–June)- and Delta (June–December)-dominant periods, 2021.

Methods

Forty-six participating hospitals across 14 countries follow a similar generic protocol using the test-negative case–control design. We defined complete primary series vaccination (PSV) as two doses of a two-dose or one of a single-dose vaccine ≥ 14 days before onset.

Results

We included 1,087 cases (538 controls) and 1,669 cases (1,442 controls) in the Alpha- and Delta-dominant periods, respectively. During the Alpha period, VE against hospitalisation with SARS-CoV2 for complete Comirnaty PSV was 85% (95% CI: 69–92) overall and 75% (95% CI: 42–90) in those aged ≥ 80 years. During the Delta period, among SARI patients ≥ 20 years with symptom onset ≥ 150 days from last PSV dose, VE for complete Comirnaty PSV was 54% (95% CI: 18–74). Among those receiving Comirnaty PSV and mRNA booster (any product) ≥ 150 days after last PSV dose, VE was 91% (95% CI: 57–98). In time-since-vaccination analysis, complete all-product PSV VE was > 90% in those with their last dose < 90 days before onset; ≥ 70% in those 90–179 days before onset.

Conclusions

Our results from this EU multi-country hospital setting showed that VE for complete PSV alone was higher in the Alpha- than the Delta-dominant period, and addition of a first booster dose during the latter period increased VE to over 90%.

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2023-11-23
2024-04-27
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Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Angela+MC+Rose&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rose Angela MC</a>, <a href="/search?value1=Nathalie+Nicolay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nicolay Nathalie</a>, <a href="/search?value1=Virginia+Sandonis+Mart%C3%ADn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sandonis Martín Virginia</a>, <a href="/search?value1=Clara+Mazagatos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mazagatos Clara</a>, <a href="/search?value1=Goranka+Petrovi%C4%87&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petrović Goranka</a>, <a href="/search?value1=F+Annabel+Niessen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Niessen F Annabel</a>, <a href="/search?value1=Ausenda+Machado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Machado Ausenda</a>, <a 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href="/search?value1=Zvjezdana+Lovri%C4%87+Makari%C4%87&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lovrić Makarić Zvjezdana</a>, <a href="/search?value1=Patricia+CJL+Bruijning-Verhagen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bruijning-Verhagen Patricia CJL</a>, <a href="/search?value1=Ver%C3%B3nica+Gomez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gomez Verónica</a>, <a href="/search?value1=Zineb+Lesieur&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lesieur Zineb</a>, <a href="/search?value1=Cyril+Barbezange&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbezange Cyril</a>, <a href="/search?value1=Els+Van+Nedervelde&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Nedervelde Els</a>, <a href="/search?value1=Maria-Louise+Borg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Borg Maria-Louise</a>, <a href="/search?value1=Jes%C3%BAs+Castilla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Castilla Jesús</a>, <a href="/search?value1=Mihaela+Lazar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lazar Mihaela</a>, <a href="/search?value1=Joan+O%E2%80%99Donnell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">O’Donnell Joan</a>, <a href="/search?value1=Indr%C4%97+Jonikait%C4%97&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jonikaitė Indrė</a>, <a href="/search?value1=Regina+Demlov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Demlová Regina</a>, <a href="/search?value1=Marina+Amerali&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amerali Marina</a>, <a href="/search?value1=Gil+Wirtz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wirtz Gil</a>, <a href="/search?value1=Kristin+Tolksdorf&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tolksdorf Kristin</a>, <a 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Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(47):pii=2300186. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.47.2300186" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.47.2300186</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Mar 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 24 Jul 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.47.2300186
/content/10.2807/1560-7917.ES.2023.28.47.2300186
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